MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	description	Hugo	Value Type	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 1251 to 1300 of 25824 in total

Interaction Map  : High confidence
Filtered  : 1

Rank	description	Hugo	Value Type	Network Comparison Type	red	green	network_comparison
157	hepatocellular carcinoma-associated protein hca1. [refseq;acc:nm_020932]	no value	Measured	Divided	23693.7	18263	1.29736
	huntingtin interacting protein 1 (hip-i). [swissprot;acc:o00291]	HIP1	Squared	Subtracted	76438	58889.7	17548.3
	huntingtin-interacting protein hypa/fbp11 (fragment). [sptrembl;acc:o75404]	no value	Rooted		55.1113	67.5537	12.4424
	myosin heavy chain, fast skeletal muscle, embryonic (muscle embryonic myosin heavy chain) (smhce). [swissprot;acc:p11055]	MYH3	Measured		9035	7279.6	1755.4
	neurogenic differentiation factor 2 (neurod2). [swissprot;acc:q15784]	NEUROD2	Ranked		312	284	28
	transcription factor lbx1. [swissprot;acc:p52954]	LBX1		Divided	249.663	298.263	1.19466
158	breast cancer antiestrogen resistance 3. [refseq;acc:nm_003567]	BCAR3	Rooted		56.3507	66.1252	1.17346
	chromodomain helicase-dna-binding protein 3 (chd-3) (mi-2 autoantigen 240 kda protein) (mi2-alpha). [swissprot;acc:q12873]	CHD3	Ranked	Subtracted	312	284	28
	goodpasture antigen-binding protein (ec 2.7.1.37) (gpbp) (collagen type iv alpha 3 binding protein) (star-related lipid transfer protein 11) (stard11) (start domain-containing protein 11). [swissprot;acc:q9y5p4]	COL4A3BP	Squared		76360.8	58841.7	17519.1
	melanoma-associated antigen 6 (mage-6 antigen) (mage3b). [swissprot;acc:p43360]	MAGEA6	Measured	Divided	23693.7	18263	1.29736
	mosaic protein lgn. [swissprot;acc:p81274]	GPSM2	Ranked		249.663	298.263	1.19466
	myosin heavy chain, skeletal muscle, adult 1 (myosin heavy chain iix/d) (myhc-iix/d). [swissprot;acc:p12882]	MYH1	Measured	Subtracted	9035	7279.6	1755.4
	protein phosphatase 1, regulatory subunit 7; sds22. [refseq;acc:nm_002712]	PPP1R7	Rooted		149.397	136.972	12.425
	septin 7 (cdc10 protein homolog). [swissprot;acc:q16181]	SEPT7	Squared	Divided	89182.8	125229	1.40418
159	doc-1 related protein (doc-1r). [swissprot;acc:o75956]	CDK2AP2	Ranked	Subtracted	312	284	28
	huntingtin interacting protein 1 related (hip1-related) (hip 12). [swissprot;acc:o75146]	HIP1R	Squared		76296.4	58801.6	17494.8
	myosin heavy chain, cardiac muscle beta isoform (myhc-beta). [swissprot;acc:p12883]	no value	Measured		9035	7279.6	1755.4
	necdin. [swissprot;acc:q99608]	NDN		Divided	23693.7	18263	1.29736
	regulator of g-protein signaling 17 (rgs17). [swissprot;acc:q9ugc6]	RGS17	Ranked		249.663	298.263	1.19466
	rna-binding protein. [refseq;acc:nm_019027]	no value	Rooted		52.7642	61.9019	1.17318
	septin 6. [swissprot;acc:q14141]	SEPT6	Squared		88953.6	124854	1.40359
	ubiquitin activating enzyme e1-like protein. [refseq;acc:nm_006395]	no value	Rooted	Subtracted	113.983	101.979	12.004
160	apobec-1 complementation factor isoform 1; apobec-1 stimulating protein; apo-b rna editing protein. [refseq;acc:nm_014576]			Divided	52.7642	61.9019	1.17318
	dj756n5.1.1 (continues in em:al133324 as dj1161h23.3) (fragment). [sptrembl;acc:q9h430]	MYH7B	Measured	Subtracted	9035	7279.6	1755.4
	guanine nucleotide-binding protein g(o), alpha subunit 1. [swissprot;acc:p09471]	GNAO1	Ranked	Divided	249.663	298.263	1.19466
	homeobox protein hox-c4 (hox-3e) (cp19). [swissprot;acc:p09017]	no value	Squared		173408	242989	1.40126
	kv channel interacting protein 1; vesicle apc-binding protein; a-type potassium channel modulatory protein 1. [refseq;acc:nm_014592]	KCNIP1	Rooted	Subtracted	43.4291	31.7159	11.7132
	melanoma-associated antigen d1 (mage-d1 antigen) (neurotrophin receptor-interacting mage homolog) (pro2292). [swissprot;acc:q9y5v3]	MAGED1	Measured	Divided	23693.7	18263	1.29736
	neurogenic differentiation factor 6 (neurod6) (my051 protein). [swissprot;acc:q96nk8]	NEUROD6	Ranked	Subtracted	312	284	28
	t-complex protein 1, gamma subunit (tcp-1-gamma) (cct-gamma). [swissprot;acc:p49368]	CCT3	Squared		42788.3	60162.6	17374.3
161	homeobox protein hox-b4 (hox-2f) (hox-2.6). [swissprot;acc:p17483]	HOXB4		Divided	173408	242989	1.40126
	melanoma-associated antigen f1 (mage-f1 antigen). [swissprot;acc:q9hay2]	MAGEF1	Measured		23693.7	18263	1.29736
	myosin heavy chain, skeletal muscle, extraocular (myhc-eo). [swissprot;acc:q9ukx3]	MYH13		Subtracted	9035	7279.6	1755.4
	neurogenic differentiation factor 1 (neurod1) (neurod). [swissprot;acc:q13562]	NEUROD1	Ranked		312	284	28
	ns1-associated protein 1. [refseq;acc:nm_006372]	SYNCRIP	Rooted	Divided	52.7642	61.9019	1.17318
	potassium channel-interacting protein 4 isoform 4; calsenilin-like protein. [refseq;acc:nm_147183]	KCNIP4		Subtracted	43.4519	31.7522	11.6997
	rap1 gtpase-activating protein 1 (rap1gap). [swissprot;acc:p47736]	RAP1GAP	Ranked	Divided	249.663	298.263	1.19466
	trna (5-methylaminomethyl-2-thiouridylate)-methyltransferase (ec 2.1.1.61). [swissprot;acc:o75648]	TRMU	Squared	Subtracted	52591.3	69845.1	17253.8
162	atlastin; guanylate-binding protein 3. [refseq;acc:nm_015915]	no value	Ranked		142	170	28
	heterogeneous nuclear ribonucleoprotein r (hnrnp r). [swissprot;acc:o43390]	HNRNPR	Rooted	Divided	52.7642	61.9019	1.17318
	high-mobility group 20a. [refseq;acc:nm_018200]	HMG20A	Measured	Subtracted	5140.14	6893.53	1753.39
	homeobox protein hox-c5 (hox-3d) (cp11). [swissprot;acc:q00444]	HOXC5	Squared	Divided	173408	242989	1.40126
	kv channel interacting protein 2 isoform 4; a-type potassium channel modulatory protein 2; cardiac voltage gated potassium channel modulatory subunit. [refseq;acc:nm_173193]	KCNIP2	Rooted	Subtracted	43.4554	31.7576	11.6978
	melanoma antigen, family b, 6. [refseq;acc:nm_173523]	MAGEB6B	Measured	Divided	23693.7	18263	1.29736
	nostrin. [refseq;acc:nm_052946]	NOSTRIN	Ranked		209.299	249.187	1.19058
	stem cell growth factor; lymphocyte secreted c-type lectin; lymphocyte secreted c-type lectin. [refseq;acc:nm_002975]	CLEC11A	Squared	Subtracted	59704	76460.4	16756.4
163	20 kda nuclear cap binding protein (ncbp 20 kda subunit) (cbp20) (ncbp interacting protein 1) (nip1). [swissprot;acc:p52298]	NCBP2	Rooted		54.935	66.6101	11.6751
	beta-arrestin 2 (arrestin, beta 2). [swissprot;acc:p32121]	ARRB2	Ranked		133	105	28
	c-type lectin superfamily member 1 precursor (cartilage-derived c-type lectin). [swissprot;acc:o75596]	CLEC3A	Squared		59464	76120.8	16656.8
	eap30 subunit of ell complex. [refseq;acc:nm_007241]	SNF8	Ranked	Divided	209.299	249.187	1.19058

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.