MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	description	Gene	Hugo	Value Type	Network Comparison Type	Interaction Map	Filtered	red	network_comparison	green

Results: HTML CSV LaTeX

Showing element 1230 to 1279 of 3228 in total

Value Type  : Ranked
Network Comparison Type  : Divided
Interaction Map  : High confidence
Filtered  : 1

Rank	description	Hugo	red	network_comparison	green
1230	interleukin-4 induced protein 1 precursor (fig-1 protein). [swissprot;acc:q96rq9]	IL4I1	219.55	1.02456	214.288
1231	putative phosphoglycerate mutase 3 (ec 5.4.2.1) (ec 5.4.2.4) (ec 3.1.3.13). [swissprot;acc:q8n0y7]	PGAM4	212.724	1.0245	207.637
1232	pyrroline-5-carboxylate reductase (ec 1.5.1.2) (p5cr) (p5c reductase). [swissprot;acc:p32322]	PYCR1	172.543		168.417
1233	phosphoglycerate mutase 1 (ec 5.4.2.1) (ec 5.4.2.4) (ec 3.1.3.13) (phosphoglycerate mutase isozyme b) (pgam-b) (bpg-dependent pgam 1). [swissprot;acc:p18669]	no value	212.724		207.637
1234	phosphoglycerate mutase 2 (ec 5.4.2.1) (ec 5.4.2.4) (ec 3.1.3.13) (phosphoglycerate mutase isozyme m) (pgam-m) (bpg-dependent pgam 2) (muscle-specific phosphoglycerate mutase). [swissprot;acc:p15259]	PGAM2
1235	keratin associated protein 9-4; keratin associated protein 9.4. [refseq;acc:nm_033191]	no value	219.356	1.02447	224.723
1236	keratin associated protein 4-10; keratin associated protein 4.10. [refseq;acc:nm_033060]		219.354	1.02437	224.699
1237	keratin associated protein 4-2; keratin associated protein 4.2. [refseq;acc:nm_033062]
1238	keratin associated protein 4.3 (fragment). [sptrembl;acc:q9byr4]
1239	keratin associated protein 2-4; keratin associated protein 2.4. [refseq;acc:nm_033184]
1240	keratin associated protein 4-14; keratin associated protein 4.14. [refseq;acc:nm_033059]				224.7
1241	keratin associated protein 4.9 (fragment). [sptrembl;acc:q9byq8]
1242	keratin associated protein 4-12; keratin associated protein 4.12. [refseq;acc:nm_031854]
1243	keratin associated protein 1.5. [refseq;acc:nm_031957]				224.699
1244	star-related lipid transfer protein 6 (stard6) (start domain- containing protein 6). [swissprot;acc:p59095]	STARD6			224.7
1245	keratin, ultra high-sulfur matrix protein b (uhs keratin b) (uhs kerb). [swissprot;acc:o75690]	KRTAP5-8			224.699
1246	keratin, ultra high-sulfur matrix protein a (uhs keratin a) (uhs kera). [swissprot;acc:p26371]	no value
1247	star-related lipid transfer protein 5 (stard5) (start domain- containing protein 5). [swissprot;acc:q9nsy2]	STARD5			224.7
1248	keratin associated protein 4.4. [refseq;acc:nm_032524]	KRTAP4-4			224.699
1249	alpha-parvin (calponin-like integrin-linked kinase binding protein) (ch-ilkbp). [swissprot;acc:q9nvd7]	no value			224.7
1250	pinch protein (particularly interesting new cys-his protein) (lim and senescent cell antigen-like domains 1). [swissprot;acc:p48059]	LIMS1
1251	integrin-linked protein kinase 1 (ec 2.7.1.-) (ilk-1) (59 kda serine/threonine protein kinase) (p59ilk). [swissprot;acc:q13418]	ILK
1252	star-related lipid transfer protein 4 (stard4) (start domain- containing protein 4). [swissprot;acc:q96dr4]	STARD4
1253	ras suppressor protein 1 (rsu-1) (rsp-1). [swissprot;acc:q15404]	RSU1
1254	ras-gtpase-activating protein binding protein 1 (gap sh3-domain binding protein 1) (g3bp-1). [swissprot;acc:q13283]	G3BP1
1255	ras-gtpase-activating protein binding protein 2 (gap sh3-domain binding protein 2) (g3bp-2). [swissprot;acc:q9un86]	G3BP2
1256	keratin associated protein 1-3; keratin associated protein 1.3. [refseq;acc:nm_030966]	no value			224.699
1257	espin. [refseq;acc:nm_031475]	ESPNP			224.7
1258	cytochrome p450 2d6 (ec 1.14.14.1) (cypiid6) (p450-db1) (debrisoquine 4-hydroxylase). [swissprot;acc:p10635]	CYP2D6
1259	pleckstrin homology domain containing, family c (with ferm domain) member 1; mitogen inducible 2; kindlin 2. [refseq;acc:nm_006832]	PLEKHC1
1260	lim and senescent cell antigen-like domains 2; ilk-binding protein. [refseq;acc:nm_017980]	LIMS2
1261	d(4) dopamine receptor (d(2c) dopamine receptor). [swissprot;acc:p21917]	DRD4
1262	keratin associated protein 9.2. [refseq;acc:nm_031961]	KRTAP9-8	219.353	1.02428	224.678
1263	mitogen-activated protein kinase 12 (ec 2.7.1.37) (extracellular signal-regulated kinase 6) (erk-6) (erk5) (stress-activated protein kinase-3) (mitogen-activated protein kinase p38 gamma) (map kinase p38 gamma). [swissprot;acc:p53778]	MAPK11	171.231	1.02425	167.177
1264	sphingosine kinase 1 (ec 2.7.1.-) (sk 1) (spk 1). [swissprot;acc:q9nya1]	SPHK1
1265	udp-n-acetylglucosamine--dolichyl-phosphate n- acetylglucosaminephosphotransferase (ec 2.7.8.15) (gpt) (g1pt) (n-acetylglucosamine-1-phosphate transferase) (glcnac-1-p transferase). [swissprot;acc:q9h3h5]	DPAGT1
1266	rho-gtpase-activating protein 7 (rho-type gtpase-activating protein 7) (deleted in liver cancer 1 protein) (dlc-1) (hp protein) (star-related lipid transfer protein 12) (stard12) (start domain-containing protein 12). [swissprot;acc:q96qb1]	DLC1
1267	map kinase-activated protein kinase 2 (ec 2.7.1.-) (mapk-activated protein kinase 2) (mapkap kinase 2) (mapkapk-2). [swissprot;acc:p49137]	MAPKAPK2
1268	neuronal acetylcholine receptor protein, alpha-6 chain precursor. [swissprot;acc:q15825]	CHRNA6
1269	nitrogen fixation cluster-like. [refseq;acc:nm_014301]	ISCU
1270	star-related lipid transfer protein 13 (stard13) (start domain- containing protein 13) (46h23.2). [swissprot;acc:q9y3m8]	STARD13
1271	star-related lipid transfer protein 8 (stard8) (start domain- containing protein 8). [swissprot;acc:q92502]	STARD8
1272	neuronal acetylcholine receptor protein, alpha-2 chain precursor. [swissprot;acc:q15822]	CHRNA2
1273	mitogen-activated protein kinase-activated protein kinase 3; mapkap kinase 3. [refseq;acc:nm_004635]	MAPKAPK3
1274	mitogen-activated protein kinase 14 (ec 2.7.1.37) (mitogen-activated protein kinase p38alpha) (map kinase p38alpha) (cytokine suppressive anti-inflammatory drug binding protein) (csaid binding protein) (csbp) (max-interacting protein 2) (map kinase mxi2) (sapk2a). [swissprot;acc:q16539]	MAPK14
1275	neuronal acetylcholine receptor protein, alpha-4 chain precursor. [swissprot;acc:p43681]	CHRNA4
1276	neuronal acetylcholine receptor protein, alpha-3 chain precursor. [swissprot;acc:p32297]	CHRNA3
1277	sphingosine kinase 2 (ec 2.7.1.-) (sk 2) (spk 2). [swissprot;acc:q9nra0]	SPHK2
1278	sestrin 3. [swissprot;acc:p58005]	SESN3	218.368	1.02415	213.219
1279	sestrin 2 (hi95). [swissprot;acc:p58004]	SESN2

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.