MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	description	Hugo	Network Comparison Type	Value Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 123 to 172 of 3228 in total

Network Comparison Type  : Divided
Value Type  : Ranked
Interaction Map  : High confidence
Filtered  : 1

Rank	description	Hugo	red	green	network_comparison
123	potassium voltage-gated channel, shal-related subfamily, member 1; shal-type potassium channel; voltage-gated potassium channel kv4.1. [refseq;acc:nm_004979]	KCND1	269.23	327.601	1.21681
124	high-mobility group 20b; sox-like transcriptional factor; swi/snf-related matrix-associated actin-dependent regulator of chromatin subfamily e, member 1-related. [refseq;acc:nm_006339]	HMG20B	208.52	171.595	1.21519
125	high-mobility group 20a. [refseq;acc:nm_018200]	HMG20A	208.588	171.778	1.21429
126	associated molecule with the sh3 domain of stam (amsh) like protein. [refseq;acc:nm_020799]	STAMBPL1	94	114	1.21277
127	putative breast adenocarcinoma marker (32kd). [refseq;acc:nm_014453]	CHMP2A
128	associated molecule with the sh3 domain of stam. [refseq;acc:nm_006463]	STAMBP
129	neuroendocrine differentiation factor; comparative gene identification transcript 149. [refseq;acc:nm_016079]	VPS24
130	protein hspc134 (protein cda04). [swissprot;acc:q9by43]	CHMP4A
131	son protein (son3) (negative regulatory element-binding protein) (nre- binding protein) (dbp-5) (bax antagonist selected in saccharomyces 1) (bass1) (protein c21orf50). [swissprot;acc:p18583]	SON	294.053	242.562	1.21228
132	tob2 protein (transducer of erbb-2 2). [swissprot;acc:q14106]	TOB2	350	290	1.2069
133	tob1 protein (transducer of erbb-2 1). [swissprot;acc:p50616]	TOB1
134	dab2 interacting protein; ngap-like protein; doc-2/dab2 interactive protein. [refseq;acc:nm_032552]	DAB2IP
135	cytoplasmic polyadenylation element binding protein 4. [refseq;acc:nm_030627]	CPEB4
136	cytoplasmic polyadenylation element binding protein 3. [refseq;acc:nm_014912]	CPEB3
137	ras gtpase-activating protein ngap (ras protein activator like 1). [swissprot;acc:q9ujf2]	RASAL2
138	serine/threonine protein phosphatase 2a, catalytic subunit, alpha isoform (ec 3.1.3.16) (pp2a-alpha) (replication protein c) (rp-c). [swissprot;acc:p05323]	PPP2CA	194.372	234.204	1.20493
139	amyloid beta a4 precursor protein-binding family a member 1 (neuron- specific x11 protein) (neuronal munc18-1-interacting protein 1) (mint-1) (adapter protein x11alpha). [swissprot;acc:q02410]	APBA1	271.752	225.68	1.20415
140	ras-related gtp binding a; ras-related gtp-binding protein. [refseq;acc:nm_006570]	RRAGA	59	49	1.20408
141	ras-related gtp binding c; rag c protein. [refseq;acc:nm_022157]	RRAGC
142	ras-related gtp binding b short isoform; gtp-binding protein ragb. [refseq;acc:nm_006064]	RRAGB
143	anillin, actin binding protein (scraps homolog, drosophila); anillin (drosophila scraps homolog), actin binding protein. [refseq;acc:nm_018685]	ANLN
144	kv channel interacting protein 1; vesicle apc-binding protein; a-type potassium channel modulatory protein 1. [refseq;acc:nm_014592]	KCNIP1	265.686	319.651	1.20312
145	potassium channel-interacting protein 4 isoform 4; calsenilin-like protein. [refseq;acc:nm_147183]	KCNIP4	265.639	319.546	1.20293
146	kv channel interacting protein 2 isoform 4; a-type potassium channel modulatory protein 2; cardiac voltage gated potassium channel modulatory subunit. [refseq;acc:nm_173193]	KCNIP2	265.632	319.531	1.20291
147	nuclear dna-binding protein; small unique nuclear receptor corepressor; c1d dna-binding protein. [refseq;acc:nm_006333]	no value	50.7983	42.3003	1.2009
148	sad1/unc-84 protein-like 1. [swissprot;acc:o94901]	UNC84A	296.677	247.559	1.19841
149	atlastin; guanylate-binding protein 3. [refseq;acc:nm_015915]	no value	142	170	1.19718
150	myosin vb (myosin 5b) (fragment). [swissprot;acc:q9ulv0]	MYO5B	55	46	1.19565
151	myosin vc (myosin 5c). [swissprot;acc:q9nqx4]	MYO5C
152	myosin va (myosin 5a) (dilute myosin heavy chain, non-muscle) (myosin heavy chain 12) (myoxin). [swissprot;acc:q9y4i1]	no value
153	chromosome 3p21.1 gene sequence. [refseq;acc:nm_013286]	RBM15B	249.663	298.263	1.19466
154	regulator of g-protein signaling 19 (rgs19) (g-alpha interacting protein) (gaip protein). [swissprot;acc:p49795]	RGS19
155	putative rna-binding protein 15 (rna binding motif protein 15) (one-twenty two protein). [swissprot;acc:q96t37]	RBM15
156	regulator of g-protein signaling 20 (rgs20) (regulator of gz- selective protein signaling 1) (gz-selective gtpase-activating protein) (g(z)gap). [swissprot;acc:o76081]	RGS20
157	transcription factor lbx1. [swissprot;acc:p52954]	LBX1
158	mosaic protein lgn. [swissprot;acc:p81274]	GPSM2
159	regulator of g-protein signaling 17 (rgs17). [swissprot;acc:q9ugc6]	RGS17
160	guanine nucleotide-binding protein g(o), alpha subunit 1. [swissprot;acc:p09471]	GNAO1
161	rap1 gtpase-activating protein 1 (rap1gap). [swissprot;acc:p47736]	RAP1GAP
162	nostrin. [refseq;acc:nm_052946]	NOSTRIN	209.299	249.187	1.19058
163	eap30 subunit of ell complex. [refseq;acc:nm_007241]	SNF8
164	liv-1 protein, estrogen regulated. [refseq;acc:nm_012319]	SLC39A6
165	glutamate decarboxylase, 65 kda isoform (ec 4.1.1.15) (gad-65) (65 kda glutamic acid decarboxylase). [swissprot;acc:q05329]	GAD2
166	gamma-soluble nsf attachment protein (snap-gamma) (n-ethylmaleimide- sensitive factor attachment protein, gamma). [swissprot;acc:q99747]	NAPG
167	glutamate decarboxylase, 67 kda isoform (ec 4.1.1.15) (gad-67) (67 kda glutamic acid decarboxylase). [swissprot;acc:q99259]	GAD1
168	gaba-a receptor-associated protein. [sptrembl;acc:q9by60]	no value	82.5916	98.0548	1.18722
169	apg3p; pc3-96 protein. [refseq;acc:nm_022488]	ATG3
170	nucleolysin tia-1 (rna-binding protein tia-1) (p40-tia-1) [contains: p15-tia-1]. [swissprot;acc:p31483]	TIA1	227.199	192.715	1.17894
171	nucleolysin tiar (tia-1 related protein). [swissprot;acc:q01085]	TIAL1	227.202	192.823	1.17829
172	cg9578-like; yeast ypr037w and worm c02c2.6 predicted proteins-like. [refseq;acc:nm_152902]	TIPRL	174.667	205.556	1.17685

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.