MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	Hugo	description	Network Comparison Type	Value Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 1212 to 1261 of 25824 in total

Interaction Map  : High confidence
Filtered  : 1

Rank	Hugo	description	Network Comparison Type	Value Type	red	green	network_comparison
152	LUC7L2	luc7-like 2; cgi-74 protein; cgi-59 protein. [refseq;acc:nm_016019]	Divided	Rooted	55.2859	65.9288	1.19251
	MAGED4	melanoma antigen, family d, 4 isoform 1; mage1 protein; mage-e1 protein; maged4 protein. [refseq;acc:nm_030801]		Measured	23693.7	18263	1.29736
	SEPT8	septin-like protein kiaa0202 (fragment). [swissprot;acc:q92599]		Squared	90226	126939	1.4069
	SLC15A1	oligopeptide transporter, small intestine isoform (peptide transporter 1) (intestinal h+/peptide cotransporter) (solute carrier family 15, member 1). [swissprot;acc:p46059]	Subtracted		73995.1	56003.7	17991.4
	SNRP70	u1 small nuclear ribonucleoprotein 70 kda (u1 snrnp 70 kda) (snrnp70) (u1-70k). [swissprot;acc:p08621]		Ranked	226.582	198.444	28.138
153	no value	filamin a (alpha-filamin) (filamin 1) (endothelial actin-binding protein) (abp-280) (nonmuscle filamin). [swissprot;acc:p21333]
		myosin heavy chain, cardiac muscle alpha isoform (myhc-alpha). [swissprot;acc:p13533]		Measured	9035	7279.6	1755.4
		ret finger protein 2 (leukemia associated protein 5) (b-cell chronic lymphocytic leukemia tumor suppressor leu5) (putative tumor suppressor rfp2) (tripartite motif protein 13). [swissprot;acc:o60858]	Divided	Squared	70011	49783	1.40632
	HOMER1	homer, neuronal immediate early gene, 1b. [refseq;acc:nm_004272]	Subtracted	Rooted	50.3333	62.9942	12.6609
	LUC7L	luc7-like; sarcoplasmic reticulum protein luc7b1. [refseq;acc:nm_018032]	Divided		55.297	65.9236	1.19217
	MAGEE2	hepatocellular carcinoma-associated protein hca3. [refseq;acc:nm_138703]		Measured	23693.7	18263	1.29736
	RBM15B	chromosome 3p21.1 gene sequence. [refseq;acc:nm_013286]		Ranked	249.663	298.263	1.19466
	SLC15A2	oligopeptide transporter, kidney isoform (peptide transporter 2) (kidney h+/peptide cotransporter) (solute carrier family 15, member 2). [swissprot;acc:q16348]	Subtracted	Squared	73510.2	55607.3	17902.9
154	no value	melanoma-associated antigen 3 (mage-3 antigen) (antigen mz2-d). [swissprot;acc:p43357]	Divided	Measured	23693.7	18263	1.29736
	CCT3	t-complex protein 1, gamma subunit (tcp-1-gamma) (cct-gamma). [swissprot;acc:p49368]		Squared	42788.3	60162.6	1.40605
	EIF5	eukaryotic translation initiation factor 5 (eif-5). [swissprot;acc:p55010]		Rooted	43.5479	51.5473	1.18369
	HOMER3	homer, neuronal immediate early gene, 3. [refseq;acc:nm_004838]	Subtracted		50.339	62.9975	12.6585
	MSI2	musashi 2 isoform a. [refseq;acc:nm_138962]		Ranked	227.491	199.458	28.033
	MYH4	myosin heavy chain, skeletal muscle, fetal (myosin heavy chain iib) (myhc-iib). [swissprot;acc:q9y623]		Measured	9035	7279.6	1755.4
	RGS19	regulator of g-protein signaling 19 (rgs19) (g-alpha interacting protein) (gaip protein). [swissprot;acc:p49795]	Divided	Ranked	249.663	298.263	1.19466
	SLC4A1AP	solute carrier family 4 (anion exchanger), member 1, adaptor protein; kidney anion exchanger adaptor protein; kanadaptin; lung cancer oncogene 3. [refseq;acc:nm_018158]	Subtracted	Squared	70525.9	52678.7	17847.2
155	CKS2	cyclin-dependent kinases regulatory subunit 2 (cks-2). [swissprot;acc:p33552]
	CSTF2	cleavage stimulation factor, 64 kda subunit (cstf 64 kda subunit) (cf-1 64 kda subunit). [swissprot;acc:p33240]	Divided		126408	89940.5	1.40546
	MAGEA11	melanoma-associated antigen 11 (mage-11 antigen). [swissprot;acc:p43364]		Measured	23693.7	18263	1.29736
	MSI1	musashi 1. [refseq;acc:nm_002442]	Subtracted	Ranked	227.491	199.458	28.033
	MYH8	myosin heavy chain, skeletal muscle, perinatal (myhc-perinatal). [swissprot;acc:p13535]		Measured	9035	7279.6	1755.4
	NCBP2L	dj820b18.1 (similar to nuclear cap binding protein) (fragment). [sptrembl;acc:q8wwk2]		Rooted	54.2343	66.7323	12.498
	RBM15	putative rna-binding protein 15 (rna binding motif protein 15) (one-twenty two protein). [swissprot;acc:q96t37]	Divided	Ranked	249.663	298.263	1.19466
	SNRPD2	small nuclear ribonucleoprotein sm d2 (snrnp core protein d2) (sm-d2). [swissprot;acc:p43330]		Rooted	55.7423	65.6839	1.17835
156	no value	formin binding protein 3; fas-ligand associated factor 1; huntingtin-interacting protein a; ny-ren-6 antigen. [refseq;acc:nm_017892]	Subtracted		55.1026	67.5701	12.4675
	CTNNAL1	catenin (cadherin-associated protein), alpha-like 1; alpha-catulin. [refseq;acc:nm_003798]		Squared	70525.9	52678.7	17847.2
	MAGEA2B	melanoma-associated antigen 2 (mage-2 antigen). [swissprot;acc:p43356]	Divided	Measured	23693.7	18263	1.29736
	MYH2	myosin heavy chain, skeletal muscle, adult 2 (myosin heavy chain iia) (myhc-iia). [swissprot;acc:q9ukx2]	Subtracted		9035	7279.6	1755.4
	RGS20	regulator of g-protein signaling 20 (rgs20) (regulator of gz- selective protein signaling 1) (gz-selective gtpase-activating protein) (g(z)gap). [swissprot;acc:o76081]	Divided	Ranked	249.663	298.263	1.19466
	SEPT10	septin 10 isoform 1. [refseq;acc:nm_144710]		Squared	89578.7	125883	1.40528
	SH2D3C	sh2 domain containing 3c; novel sh2-containing protein 3; sh2 domain-containing 3c; likely ortholog of mouse cas/hef1-associated signal transducer. [refseq;acc:nm_005489]		Rooted	56.3447	66.124	1.17356
	ZC3H14	nuclear protein ukp68. [refseq;acc:nm_024824]	Subtracted	Ranked	227.491	199.458	28.033
157	no value	hepatocellular carcinoma-associated protein hca1. [refseq;acc:nm_020932]	Divided	Measured	23693.7	18263	1.29736
		huntingtin-interacting protein hypa/fbp11 (fragment). [sptrembl;acc:o75404]	Subtracted	Rooted	55.1113	67.5537	12.4424
	BRP44	brain protein 44. [swissprot;acc:o95563]	Divided	Squared	89182.8	125229	1.40418
	EIF4G3	eukaryotic translation initiation factor 4 gamma, 3. [refseq;acc:nm_003760]		Rooted	52.7582	61.9123	1.17351
	HIP1	huntingtin interacting protein 1 (hip-i). [swissprot;acc:o00291]	Subtracted	Squared	76438	58889.7	17548.3
	LBX1	transcription factor lbx1. [swissprot;acc:p52954]	Divided	Ranked	249.663	298.263	1.19466
	MYH3	myosin heavy chain, fast skeletal muscle, embryonic (muscle embryonic myosin heavy chain) (smhce). [swissprot;acc:p11055]	Subtracted	Measured	9035	7279.6	1755.4
	NEUROD2	neurogenic differentiation factor 2 (neurod2). [swissprot;acc:q15784]		Ranked	312	284	28
158	BCAR3	breast cancer antiestrogen resistance 3. [refseq;acc:nm_003567]	Divided	Rooted	56.3507	66.1252	1.17346
	CHD3	chromodomain helicase-dna-binding protein 3 (chd-3) (mi-2 autoantigen 240 kda protein) (mi2-alpha). [swissprot;acc:q12873]	Subtracted	Ranked	312	284	28
	COL4A3BP	goodpasture antigen-binding protein (ec 2.7.1.37) (gpbp) (collagen type iv alpha 3 binding protein) (star-related lipid transfer protein 11) (stard11) (start domain-containing protein 11). [swissprot;acc:q9y5p4]		Squared	76360.8	58841.7	17519.1
	GPSM2	mosaic protein lgn. [swissprot;acc:p81274]	Divided	Ranked	249.663	298.263	1.19466
	MAGEA6	melanoma-associated antigen 6 (mage-6 antigen) (mage3b). [swissprot;acc:p43360]		Measured	23693.7	18263	1.29736

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.