MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

Navigation/Query Panel:
Click on the attribute name to hide/unhide it. The green arrows can be used to shift columns left/right. Exact word match is written as =..., regular expressions can be matched with ~.... To select all values larger or equal than use >.... This would be <... for values smaller or equal than. To select all values within a specific range use [...,...].

Rank	Gene	Hugo	description	Value Type	Network Comparison Type	Interaction Map	red	Filtered	green	network_comparison

Results: HTML CSV LaTeX

Showing element 1208 to 1257 of 6456 in total

Value Type  : Ranked
Interaction Map  : High confidence
Filtered  : 1

Rank	Hugo	description	Network Comparison Type	red	green	network_comparison
604	RPL15	60s ribosomal protein l15. [swissprot;acc:p39030]	Divided	217.862	230.978	1.0602
605	HIST1H2BL	histone h2b.c (h2b/c). [swissprot;acc:q99880]		247.47	233.441	1.0601
	LEF1	lymphoid enhancer binding factor 1 (lef-1) (t cell-specific transcription factor 1-alpha) (tcf1-alpha). [swissprot;acc:q9uju2]	Subtracted	225.829	212.945	12.884
606	HIST2H2BA	histone h2b.q (h2b/q) (h2b-gl105). [swissprot;acc:q16778]	Divided	247.47	233.441	1.0601
	WASL	neural wiskott-aldrich syndrome protein (n-wasp). [swissprot;acc:o00401]	Subtracted	207.309	194.452	12.857
607	no value	histone h3.1 (h3/a) (h3/c) (h3/d) (h3/f) (h3/h) (h3/i) (h3/j) (h3/k) (h3/l). [swissprot;acc:p16106]	Divided	247.47	233.441	1.0601
	SCOC	short coiled-coil protein; short coiled coil protein. [refseq;acc:nm_032547]	Subtracted	216.731	229.549	12.818
608	no value	histone h2b. [refseq;acc:nm_175055]	Divided	247.47	233.441	1.0601
	DYNLL2	dynein light chain 2. [refseq;acc:nm_080677]	Subtracted	216.731	229.549	12.818
609	no value	dead-box protein abstrakt homolog. [swissprot;acc:q9ujv9]		226.523	213.786	12.737
		histone h2b.s (h2b/s). [swissprot;acc:p57053]	Divided	247.47	233.441	1.0601
610		histone h2b.d (h2b/d). [swissprot;acc:q99877]
	SOS1	son of sevenless protein homolog 1 (sos-1). [swissprot;acc:q07889]	Subtracted	205.74	193.021	12.719
611	no value	u6 snrna-associated sm-like protein lsm7. [swissprot;acc:q9uk45]		228.986	216.276	12.71
	HIST3H3	histone h3.4 (h3t) (h3/t) (h3/g). [swissprot;acc:q16695]	Divided	247.47	233.441	1.0601
612	HIST1H2BA	testis-specific histone h2b; h2b histone family, member u, (testis-specific). [refseq;acc:nm_170610]
	SOS2	son of sevenless protein homolog 2 (sos-2). [swissprot;acc:q07890]	Subtracted	205.89	193.183	12.707
613	no value	histone h2b.e (h2b/e). [swissprot;acc:q99879]	Divided	247.47	233.441	1.0601
	NOL5A	nucleolar protein nop56 (nucleolar protein 5a). [swissprot;acc:o00567]	Subtracted	247.769	235.074	12.695
614	HOXA10	homeobox protein hox-a10 (hox-1h) (hox-1.8) (pl). [swissprot;acc:p31260]	Divided	214.257	202.125	1.06002
	YARS	tyrosyl-trna synthetase (ec 6.1.1.1) (tyrosyl--trna ligase) (tyrrs). [swissprot;acc:p54577]	Subtracted	232.468	245.048	12.58
615	HOXB9	homeobox protein hox-b9 (hox-2e) (hox-2.5). [swissprot;acc:p17482]	Divided	214.257	202.132	1.05999
	POLE	dna polymerase epsilon, catalytic subunit a (ec 2.7.7.7) (dna polymerase ii subunit a). [swissprot;acc:q07864]	Subtracted	241.907	229.35	12.557
616	CPA3	mast cell carboxypeptidase a precursor (ec 3.4.17.1) (mc-cpa) (carboxypeptidase a3). [swissprot;acc:p15088]		177.698	190.24	12.542
	HOXA9	homeobox protein hox-a9 (hox-1g). [swissprot;acc:p31269]	Divided	214.257	202.132	1.05999
617	CPA6	carboxypeptidase b precursor. [refseq;acc:nm_020361]	Subtracted	177.698	190.239	12.541
	HOXC9	homeobox protein hox-c9 (hox-3b). [swissprot;acc:p31274]	Divided	214.257	202.135	1.05997
618	CPB2	plasma carboxypeptidase b2 isoform a preproprotein; carboxypeptidase u; thrombin-activatable fibrinolysis inhibitor; carboxypeptidase b-like protein; thrombin-activable fibrinolysis inhibitor. [refseq;acc:nm_001872]	Subtracted	177.699	190.24	12.541
	GABRG3	gamma-aminobutyric-acid receptor gamma-3 subunit precursor (gaba(a) receptor). [swissprot;acc:q99928]	Divided	214.256	202.139	1.05994
619	FOXG1	forkhead box protein g1c (forkhead-related protein fkhl3) (hfk3) (fragment). [swissprot;acc:q14488]
	VPS39	vam6/vps39-like protein (hvam6p). [swissprot;acc:q96jc1]	Subtracted	206.274	218.792	12.518
620	GABRG1	gamma-aminobutyric-acid receptor gamma-1 subunit precursor (gaba(a) receptor). [swissprot;acc:q8n1c3]	Divided	214.256	202.14	1.05994
	MAP4	microtubule-associated protein 4 (map 4). [swissprot;acc:p27816]	Subtracted	206.274	218.792	12.518
621	GABRA2	gamma-aminobutyric-acid receptor alpha-2 subunit precursor (gaba(a) receptor). [swissprot;acc:p47869]	Divided	214.256	202.14	1.05994
	RPLP2	60s acidic ribosomal protein p2. [swissprot;acc:p05387]	Subtracted	231.92	244.435	12.515
622	GABRA6	gamma-aminobutyric-acid receptor alpha-6 subunit precursor (gaba(a) receptor). [swissprot;acc:q16445]	Divided	214.256	202.14	1.05994
	SYN3	synapsin iii. [swissprot;acc:o14994]	Subtracted	229.072	216.576	12.496
623	no value	aspartate beta-hydroxylase isoform b; junctin isoform 1; junctate; aspartyl/asparaginyl-beta-hydroxylase; peptide-aspartate beta-dioxygenase; humbug. [refseq;acc:nm_032468]
	GABRG2	gamma-aminobutyric-acid receptor gamma-2 subunit precursor (gaba(a) receptor). [swissprot;acc:p18507]	Divided	214.256	202.14	1.05994
624	no value	interleukin-1 receptor-associated kinase 4; interleukin-1 receptor associated kinase 4. [refseq;acc:nm_016123]			202.139
	HEY1	hairy/enhancer-of-split related with yrpw motif 1 (hairy and enhancer of split related-1) (hesr-1) (cardiovascular helix-loop-helix factor 2) (hes-related repressor protein 2 herp2). [swissprot;acc:q9y5j3]	Subtracted	229.072	216.576	12.496
625	ABLIM2	actin binding lim protein 2. [refseq;acc:nm_032432]
	GABRA4	gamma-aminobutyric-acid receptor alpha-4 subunit precursor (gaba(a) receptor). [swissprot;acc:p48169]	Divided	214.256	202.14	1.05994
626	GABRE	gamma-aminobutyric-acid receptor epsilon subunit precursor (gaba(a) receptor). [swissprot;acc:p78334]
	HEYL	hairy/enhancer-of-split related with yrpw motif-like. [refseq;acc:nm_014571]	Subtracted	229.072	216.576	12.496
627	JMJD6	phosphatidylserine receptor; phosphatidylserine receptor beta. [refseq;acc:nm_015167]	Divided	214.256	202.139	1.05994
	SYN2	synapsin ii. [swissprot;acc:q92777]	Subtracted	229.072	216.576	12.496
628	GABRA1	gamma-aminobutyric-acid receptor alpha-1 subunit precursor (gaba(a) receptor). [swissprot;acc:p14867]	Divided	214.256	202.14	1.05994
	MRRF	mitochondrial ribosome recycling factor. [refseq;acc:nm_138777]	Subtracted	229.072	216.576	12.496
629	GABRA3	gamma-aminobutyric-acid receptor alpha-3 subunit precursor (gaba(a) receptor). [swissprot;acc:p34903]	Divided	214.256	202.14	1.05994

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.