MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	Hugo	description	Value Type	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 1208 to 1257 of 8289 in total

Value Type  : Ranked
Network Comparison Type  : Divided
Filtered  : 1

Rank	Hugo	description	Interaction Map	red	green	network_comparison
604	RPL36	60s ribosomal protein l36. [swissprot;acc:q9y3u8]	Low confidence	205.116	211.234	1.02983
605	DDX17	probable rna-dependent helicase p72 (dead-box protein p72) (dead-box protein 17). [swissprot;acc:q92841]		204.837	198.913	1.02978
	HIST1H2BL	histone h2b.c (h2b/c). [swissprot;acc:q99880]	High confidence	247.47	233.441	1.0601
606	no value	dolichyl-p-man:man(5)glcnac(2)-pp-dolichyl mannosyltransferase (ec 2.4.1.-) (dol-p-man dependent alpha(1-3)-mannosyltransferase) (not56-like protein). [swissprot;acc:q92685]	Low confidence	200.085	194.301	1.02977
	HIST2H2BA	histone h2b.q (h2b/q) (h2b-gl105). [swissprot;acc:q16778]	High confidence	247.47	233.441	1.0601
607	no value	histone h3.1 (h3/a) (h3/c) (h3/d) (h3/f) (h3/h) (h3/i) (h3/j) (h3/k) (h3/l). [swissprot;acc:p16106]
	DDX5	probable rna-dependent helicase p68 (dead-box protein p68) (dead-box protein 5). [swissprot;acc:p17844]	Low confidence	204.832	198.916	1.02974
608	no value	ba161i19.3 (similar to ribosomal protein l36). [sptrembl;acc:q8wx03]		205.117	211.213	1.02972
		histone h2b. [refseq;acc:nm_175055]	High confidence	247.47	233.441	1.0601
609		histone h2b.s (h2b/s). [swissprot;acc:p57053]
	TP63	tumor protein p73-like; tumor protein 63 kda with strong homology to p53; tumor protein p63. [refseq;acc:nm_003722]	Low confidence	191.867	186.346	1.02963
610	no value	histone h2b.d (h2b/d). [swissprot;acc:q99877]	High confidence	247.47	233.441	1.0601
	TP73	tumor protein p73 (p53-like transcription factor) (p53-related protein). [swissprot;acc:o15350]	Low confidence	191.871	186.351	1.02962
611	HIST3H3	histone h3.4 (h3t) (h3/t) (h3/g). [swissprot;acc:q16695]	High confidence	247.47	233.441	1.0601
	TP53	cellular tumor antigen p53 (tumor suppressor p53) (phosphoprotein p53) (antigen ny-co-13). [swissprot;acc:p04637]	Low confidence	191.875	186.357	1.02961
612	HIST1H2BA	testis-specific histone h2b; h2b histone family, member u, (testis-specific). [refseq;acc:nm_170610]	High confidence	247.47	233.441	1.0601
	PDIA4	protein disulfide isomerase a4 precursor (ec 5.3.4.1) (protein erp-72) (erp72). [swissprot;acc:p13667]	Low confidence	204.388	198.518	1.02957
613	no value	histone h2b.e (h2b/e). [swissprot;acc:q99879]	High confidence	247.47	233.441	1.0601
	FAIM2	lifeguard; kiaa0950 protein. [refseq;acc:nm_012306]	Low confidence	203.626	197.78	1.02956
614	CCNA1	cyclin a1. [swissprot;acc:p78396]		187.808	182.419	1.02954
	HOXA10	homeobox protein hox-a10 (hox-1h) (hox-1.8) (pl). [swissprot;acc:p31260]	High confidence	214.257	202.125	1.06002
615	ARPC2	arp2/3 complex 34 kda subunit (p34-arc) (actin-related protein 2/3 complex subunit 2). [swissprot;acc:o15144]	Low confidence	203.495	197.661	1.02952
	HOXB9	homeobox protein hox-b9 (hox-2e) (hox-2.5). [swissprot;acc:p17482]	High confidence	214.257	202.132	1.05999
616	HOXA9	homeobox protein hox-a9 (hox-1g). [swissprot;acc:p31269]
	SURF1	surfeit locus protein 1. [swissprot;acc:q15526]	Low confidence	201.211	195.459	1.02943
617	HOXC9	homeobox protein hox-c9 (hox-3b). [swissprot;acc:p31274]	High confidence	214.257	202.135	1.05997
	ZMPSTE24	caax prenyl protease 1 homolog (ec 3.4.24.-) (prenyl protein-specific endoprotease 1) (farnesylated-proteins converting enzyme 1) (face-1) (zinc metalloproteinase ste24 homolog). [swissprot;acc:o75844]	Low confidence	203.738	197.913	1.02943
618	GABRG3	gamma-aminobutyric-acid receptor gamma-3 subunit precursor (gaba(a) receptor). [swissprot;acc:q99928]	High confidence	214.256	202.139	1.05994
	SSB	lupus la protein (sjogren syndrome type b antigen) (ss-b) (la ribonucleoprotein) (la autoantigen). [swissprot;acc:p05455]	Low confidence	205.472	199.6	1.02942
619	FOXG1	forkhead box protein g1c (forkhead-related protein fkhl3) (hfk3) (fragment). [swissprot;acc:q14488]	High confidence	214.256	202.139	1.05994
	WDFY3	wd repeat and fyve domain containing 3 isoform 1. [refseq;acc:nm_014991]	Low confidence	205.129	199.271	1.0294
620	no value	sterol regulatory element binding protein-2 (srebp-2) (sterol regulatory element-binding transcription factor 2). [swissprot;acc:q12772]		203.68	197.868	1.02937
	GABRG1	gamma-aminobutyric-acid receptor gamma-1 subunit precursor (gaba(a) receptor). [swissprot;acc:q8n1c3]	High confidence	214.256	202.14	1.05994
621	GABRA2	gamma-aminobutyric-acid receptor alpha-2 subunit precursor (gaba(a) receptor). [swissprot;acc:p47869]
	SREBF1	sterol regulatory element binding protein-1 (srebp-1) (sterol regulatory element-binding transcription factor 1). [swissprot;acc:p36956]	Low confidence	203.68	197.868	1.02937
622	GABRA6	gamma-aminobutyric-acid receptor alpha-6 subunit precursor (gaba(a) receptor). [swissprot;acc:q16445]	High confidence	214.256	202.14	1.05994
	GRB2	growth factor receptor-bound protein 2 (grb2 adapter protein) (sh2/sh3 adapter grb2) (ash protein). [swissprot;acc:p29354]	Low confidence	204.479	198.65	1.02934
623	GABRG2	gamma-aminobutyric-acid receptor gamma-2 subunit precursor (gaba(a) receptor). [swissprot;acc:p18507]	High confidence	214.256	202.14	1.05994
	JARID2	jumonji protein. [swissprot;acc:q92833]	Low confidence	207.726	201.813	1.0293
624	no value	interleukin-1 receptor-associated kinase 4; interleukin-1 receptor associated kinase 4. [refseq;acc:nm_016123]	High confidence	214.256	202.139	1.05994
	NHP2L1	nhp2-like protein 1 (high mobility group-like nuclear protein 2 homolog 1) ([u4/u6.u5] tri-snrnp 15.5 kda protein) (otk27). [swissprot;acc:p55769]	Low confidence	205.16	199.322	1.02929
625	CUL1	cullin homolog 1 (cul-1). [swissprot;acc:q13616]		203.853	198.057	1.02926
	GABRA4	gamma-aminobutyric-acid receptor alpha-4 subunit precursor (gaba(a) receptor). [swissprot;acc:p48169]	High confidence	214.256	202.14	1.05994
626	GABRE	gamma-aminobutyric-acid receptor epsilon subunit precursor (gaba(a) receptor). [swissprot;acc:p78334]
	HIST3H3	histone h3.4 (h3t) (h3/t) (h3/g). [swissprot;acc:q16695]	Low confidence	204.239	198.436	1.02924
627	JMJD6	phosphatidylserine receptor; phosphatidylserine receptor beta. [refseq;acc:nm_015167]	High confidence	214.256	202.139	1.05994
	P4HB	protein disulfide isomerase precursor (pdi) (ec 5.3.4.1) (prolyl 4- hydroxylase beta subunit) (cellular thyroid hormone binding protein) (p55). [swissprot;acc:p07237]	Low confidence	204.369	198.564	1.02923
628	no value	histone h3.1 (h3/a) (h3/c) (h3/d) (h3/f) (h3/h) (h3/i) (h3/j) (h3/k) (h3/l). [swissprot;acc:p16106]		204.234	198.433
	GABRA1	gamma-aminobutyric-acid receptor alpha-1 subunit precursor (gaba(a) receptor). [swissprot;acc:p14867]	High confidence	214.256	202.14	1.05994
629	GABRA3	gamma-aminobutyric-acid receptor alpha-3 subunit precursor (gaba(a) receptor). [swissprot;acc:p34903]

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.