MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	Network Comparison Type	Hugo	Value Type	description	Interaction Map	Filtered	network_comparison	red	green

Results: HTML CSV LaTeX

Showing element 1201 to 1250 of 33156 in total

Network Comparison Type  : Divided
Filtered  : 1

Rank	Hugo	Value Type	description	Interaction Map	network_comparison	red	green
151	ABI1	Squared	spectrin sh3 domain binding protein 1; eps8 binding protein; interactor protein ablbp4; abl-interactor protein 1 long; nap1 binding protein. [refseq;acc:nm_005470]	Low confidence	1.12421	53603.3	47680.8
	CHRAC1	Rooted	chromatin accessibility complex protein 1 (chrac-1) (chrac-15) (huchrac15) (dna polymerase epsilon subunit p15). [swissprot;acc:q9nrg0]	High confidence	1.1977	38.8223	46.4975
	CTSZ	Measured	cathepsin z precursor (ec 3.4.22.-) (cathepsin x) (cathepsin p). [swissprot;acc:q9ubr2]	Low confidence	1.08628	7136.14	7751.87
		Ranked			1.06148	206.516	194.554
	DNASE2B	Squared	deoxyribonuclease ii beta isoform 1 precursor; deoxyribonuclease ii beta; endonuclease dlad. [refseq;acc:nm_021233]	High confidence	1.41786	250303	354894
	HOXC5	Rooted	homeobox protein hox-c5 (hox-3d) (cp11). [swissprot;acc:q00444]	Low confidence	1.06862	101.348	108.302
	MYO5C	Ranked	myosin vc (myosin 5c). [swissprot;acc:q9nqx4]	High confidence	1.19565	55	46
	SH2D3C	Measured	sh2 domain containing 3c; novel sh2-containing protein 3; sh2 domain-containing 3c; likely ortholog of mouse cas/hef1-associated signal transducer. [refseq;acc:nm_005489]		1.29746	4578.09	5939.91
152	no value	Ranked	myosin va (myosin 5a) (dilute myosin heavy chain, non-muscle) (myosin heavy chain 12) (myoxin). [swissprot;acc:q9y4i1]		1.19565	55	46
		Rooted	homeobox protein hox-c6 (hox-3c) (hho.c8) (cp25). [swissprot;acc:p09630]	Low confidence	1.06862	101.348	108.302
	GBAS	Measured	nipsnap2 protein (glioblastoma amplified sequence). [swissprot;acc:o75323]		1.08627	5538.35	6016.13
	HMG20A	Ranked	high-mobility group 20a. [refseq;acc:nm_018200]		1.06144	202.934	191.187
	LUC7L2	Rooted	luc7-like 2; cgi-74 protein; cgi-59 protein. [refseq;acc:nm_016019]	High confidence	1.19251	55.2859	65.9288
	MAGED4	Measured	melanoma antigen, family d, 4 isoform 1; mage1 protein; mage-e1 protein; maged4 protein. [refseq;acc:nm_030801]		1.29736	23693.7	18263
	PFKFB3	Squared	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (6pf-2-k/fru- 2,6-p2ase brain/placenta-type isozyme) (ipfk-2) [includes: 6- phosphofructo-2-kinase (ec 2.7.1.105); fructose-2,6-bisphosphatase (ec 3.1.3.46)]. [swissprot;acc:q16875]	Low confidence	1.12404	53380.6	47490
	SEPT8		septin-like protein kiaa0202 (fragment). [swissprot;acc:q92599]	High confidence	1.4069	90226	126939
153	no value		ret finger protein 2 (leukemia associated protein 5) (b-cell chronic lymphocytic leukemia tumor suppressor leu5) (putative tumor suppressor rfp2) (tripartite motif protein 13). [swissprot;acc:o60858]		1.40632	70011	49783
	HOXD4	Rooted	homeobox protein hox-d4 (hox-4b) (hox-5.1) (hho.c13). [swissprot;acc:p09016]	Low confidence	1.06862	101.348	108.302
	LUC7L		luc7-like; sarcoplasmic reticulum protein luc7b1. [refseq;acc:nm_018032]	High confidence	1.19217	55.297	65.9236
	MAGEE2	Measured	hepatocellular carcinoma-associated protein hca3. [refseq;acc:nm_138703]		1.29736	23693.7	18263
	NIPSNAP1		nipsnap1 protein. [swissprot;acc:q9bpw8]	Low confidence	1.08611	5544.97	6022.42
	PFKFB1	Squared	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 (6pf-2-k/fru- 2,6-p2ase liver isozyme) [includes: 6-phosphofructo-2-kinase (ec 2.7.1.105); fructose-2,6-bisphosphatase (ec 3.1.3.46)]. [swissprot;acc:p16118]		1.12404	53380.6	47490
	RAB11FIP4	Ranked	rab11-family interacting protein 4. [refseq;acc:nm_032932]		1.06119	183.27	172.702
	RBM15B		chromosome 3p21.1 gene sequence. [refseq;acc:nm_013286]	High confidence	1.19466	249.663	298.263
154	no value	Measured	melanoma-associated antigen 3 (mage-3 antigen) (antigen mz2-d). [swissprot;acc:p43357]		1.29736	23693.7	18263
	CCT3	Squared	t-complex protein 1, gamma subunit (tcp-1-gamma) (cct-gamma). [swissprot;acc:p49368]		1.40605	42788.3	60162.6
	DYNLT1		cytoplasmic dynein light chain (t-complex testis-specific protein 1 homolog) (protein cw-1). [swissprot;acc:q15763]	Low confidence	1.12404	53380.6	47490
	EIF5	Rooted	eukaryotic translation initiation factor 5 (eif-5). [swissprot;acc:p55010]	High confidence	1.18369	43.5479	51.5473
	HOXB5		homeobox protein hox-b5 (hox-2a) (hho.c10) (hu-1). [swissprot;acc:p09067]	Low confidence	1.06862	101.348	108.302
	RAB11FIP3	Ranked	eferin. [swissprot;acc:o75154]		1.06119	183.27	172.702
	RGS19		regulator of g-protein signaling 19 (rgs19) (g-alpha interacting protein) (gaip protein). [swissprot;acc:p49795]	High confidence	1.19466	249.663	298.263
	SLC16A2	Measured	monocarboxylate transporter 8 (mct 8) (x-linked pest-containing transporter) (mct 7). [swissprot;acc:p36021]	Low confidence	1.08517	10553.9	11452.8
155	CSTF2	Squared	cleavage stimulation factor, 64 kda subunit (cstf 64 kda subunit) (cf-1 64 kda subunit). [swissprot;acc:p33240]	High confidence	1.40546	126408	89940.5
	CTSL2	Ranked	cathepsin l2 precursor (ec 3.4.22.43) (cathepsin v) (cathepsin u). [swissprot;acc:o60911]	Low confidence	1.0605	211.818	199.734
	HOXA5	Rooted	homeobox protein hox-a5 (hox-1c). [swissprot;acc:p20719]		1.06862	101.348	108.302
	MAGEA11	Measured	melanoma-associated antigen 11 (mage-11 antigen). [swissprot;acc:p43364]	High confidence	1.29736	23693.7	18263
	PFKFB2	Squared	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 (6pf-2-k/fru- 2,6-p2ase heart-type isozyme) (pfk-2/fbpase-2) [includes: 6- phosphofructo-2-kinase (ec 2.7.1.105); fructose-2,6-bisphosphatase (ec 3.1.3.46)]. [swissprot;acc:o60825]	Low confidence	1.12404	53380.6	47490
	RBM15	Ranked	putative rna-binding protein 15 (rna binding motif protein 15) (one-twenty two protein). [swissprot;acc:q96t37]	High confidence	1.19466	249.663	298.263
	SLC16A10	Measured	solute carrier family 16 (monocarboxylic acid transporters), member 10; t-type amino acid transporter 1. [refseq;acc:nm_018593]	Low confidence	1.08517	10553.7	11452.6
	SNRPD2	Rooted	small nuclear ribonucleoprotein sm d2 (snrnp core protein d2) (sm-d2). [swissprot;acc:p43330]	High confidence	1.17835	55.7423	65.6839
156	no value	Measured	tho complex 3. [refseq;acc:nm_032361]	Low confidence	1.08467	7401.51	8028.16
		Rooted	homeobox protein hox-a4 (hox-1d) (hox-1.4). [swissprot;acc:q00056]		1.06862	101.348	108.302
	CTSL1	Ranked	cathepsin l precursor (ec 3.4.22.15) (major excreted protein) (mep). [swissprot;acc:p07711]		1.06031	211.808	199.761
	MAGEA2B	Measured	melanoma-associated antigen 2 (mage-2 antigen). [swissprot;acc:p43356]	High confidence	1.29736	23693.7	18263
	PFKFB4	Squared	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 (6pf-2-k/fru- 2,6-p2ase testis-type isozyme) [includes: 6-phosphofructo-2-kinase (ec 2.7.1.105); fructose-2,6-bisphosphatase (ec 3.1.3.46)]. [swissprot;acc:q16877]	Low confidence	1.12404	53380.6	47490
	RGS20	Ranked	regulator of g-protein signaling 20 (rgs20) (regulator of gz- selective protein signaling 1) (gz-selective gtpase-activating protein) (g(z)gap). [swissprot;acc:o76081]	High confidence	1.19466	249.663	298.263
	SEPT10	Squared	septin 10 isoform 1. [refseq;acc:nm_144710]		1.40528	89578.7	125883
	SH2D3C	Rooted	sh2 domain containing 3c; novel sh2-containing protein 3; sh2 domain-containing 3c; likely ortholog of mouse cas/hef1-associated signal transducer. [refseq;acc:nm_005489]		1.17356	56.3447	66.124
157	no value	Measured	hepatocellular carcinoma-associated protein hca1. [refseq;acc:nm_020932]		1.29736	23693.7	18263
	BRP44	Squared	brain protein 44. [swissprot;acc:o95563]		1.40418	89182.8	125229

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.