MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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description	Rank	Gene	Hugo	Network Comparison Type	Value Type	Interaction Map	Filtered	red	green	network_comparison

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Showing element 1201 to 1250 of 8289 in total

Network Comparison Type  : Divided
Value Type  : Ranked
Filtered  : 1

description	Rank	Hugo	Interaction Map	red	green	network_comparison
calsyntenin-2 precursor. [swissprot;acc:q9h4d0]	2705	CLSTN2	High confidence	188.457	188.334	1.00065
	3403		Low confidence	197.286	194.313	1.0153
calsyntenin-3 precursor. [swissprot;acc:q9bqt9]	2706	CLSTN3	High confidence	188.459	188.336	1.00065
	3399		Low confidence	197.287	194.313	1.01531
camki-like protein kinase beta isoform. [refseq;acc:nm_153498]	2722	CAMK1D		196.985	193.597	1.0175
camp response element-binding protein cre-bpa. [refseq;acc:nm_004904]	1363	CREB5	High confidence	218.591	213.899	1.02194
	1868		Low confidence	199.127	195.25	1.01986
camp responsive element binding protein 3; luman; cyclic amp response element (cre)-binding protein/activating transcription factor 1; basic leucine zipper protein; transcription factor lzip-alpha. [refseq;acc:nm_006368]	2588	CREB3		197.95	194.454	1.01798
camp responsive element binding protein-like 2. [refseq;acc:nm_001310]	3078	CREBL2	High confidence	0.00001	0.00001	1
	3780		Low confidence	200.614	197.974	1.01334
camp-dependent protein kinase type i-alpha regulatory chain (tissue- specific extinguisher-1) (tse1). [swissprot;acc:p10644]	3089	PRKAR1A	High confidence	0.00001	0.00001	1
	3424		Low confidence	199.702	196.707	1.01523
camp-dependent protein kinase type ii-alpha regulatory chain. [swissprot;acc:p13861]	1669	PRKAR2A		201.626	197.546	1.02065
	2307		High confidence	215.554	214.467	1.00507
camp-dependent protein kinase type ii-beta regulatory chain. [swissprot;acc:p31323]	1673	PRKAR2B	Low confidence	201.622	197.545	1.02064
	2313		High confidence	215.529	214.449	1.00504
camp-dependent protein kinase, alpha-catalytic subunit (ec 2.7.1.37) (pka c-alpha). [swissprot;acc:p17612]	2312	PRKACA		215.542	214.459	1.00505
	4160		Low confidence	198.28	196.223	1.01048
camp-dependent protein kinase, beta-catalytic subunit (ec 2.7.1.37) (pka c-beta). [swissprot;acc:p22694]	2311	PRKACB	High confidence	215.542	214.459	1.00505
	4159		Low confidence	198.273	196.216	1.01048
camp-dependent protein kinase, gamma-catalytic subunit (ec 2.7.1.37) (pka c-gamma). [swissprot;acc:p22612]	2309	PRKACG	High confidence	215.542	214.459	1.00505
	4161		Low confidence	198.254	196.202	1.01046
camp-regulated phosphoprotein 19 (arpp-19) [contains: camp-regulated phosphoprotein 16 (arpp-16)]. [swissprot;acc:p56211]	2230	no value		206.702	202.864	1.01892
candidate tumor suppressor in ovarian cancer 2. [refseq;acc:nm_080822]	1173	DPH1	High confidence	229.243	235.246	1.02619
	3887		Low confidence	202.018	199.477	1.01274
candidate tumor suppressor protein. [refseq;acc:nm_020381]	1696	PDSS2		201.941	197.873	1.02056
cappuccino. [refseq;acc:nm_018366]	3413	CNO		202.766	199.719	1.01526
carbohydrate (chondroitin 4) sulfotransferase 11; chondroitin 4-sulfotransferase. [refseq;acc:nm_018413]	1452	CHST11		204.525	200.2	1.0216
carbohydrate (chondroitin 4) sulfotransferase 13; chondroitin 4-o-sulfotransferase 3. [refseq;acc:nm_152889]	1451	CHST13
carbohydrate (chondroitin 6) sulfotransferase 3; chondroitin 6-sulfotransferase. [refseq;acc:nm_004273]	4556	CHST3		202.436	200.827	1.00801
carbohydrate (keratan sulfate gal-6) sulfotransferase 1; carbohydrate (chondroitin 6/keratan) sulfotransferase 1. [refseq;acc:nm_003654]	4546	CHST1
carbohydrate (n-acetylglucosamine 6-o) sulfotransferase 4; n-acetylglucosamine 6-o-sulfotransferase. [refseq;acc:nm_005769]	4552	CHST4
carbohydrate (n-acetylglucosamine 6-o) sulfotransferase 5; n-acetylglucosamine 6-o-sulfotransferase. [refseq;acc:nm_012126]	4554	CHST5
carbohydrate (n-acetylglucosamine 6-o) sulfotransferase 6; macular dystrophy, corneal, 1; carbohydate sulfotransferase 6; corneal n-acetylglucosamine 6-sulfotransferase. [refseq;acc:nm_021615]	4545	CHST6
carbohydrate (n-acetylglucosamine 6-o) sulfotransferase 7; chondroitin 6-sulfotransferase-2. [refseq;acc:nm_019886]	4551	CHST7
carbohydrate (n-acetylglucosamine-6-o) sulfotransferase 2; carbohydrate (chondroitin 6/keratan) sulfotransferase 2. [refseq;acc:nm_004267]	4547	CHST2
carbonic anhydrase-related protein 10 (carbonic anhydrase-related protein x) (carp x) (ca-rp x) (cerebral protein-15) (hucep-15). [swissprot;acc:q9ns85]	2360	CA10		205.17	201.427	1.01858
carbonic anhydrase-related protein 2 precursor (carp-2) (ca-rp ii) (ca-xi) (carbonic anhydrase-related protein 11) (carp xi) (ca-rp xi). [swissprot;acc:o75493]	2368	CA11		205.147	201.407	1.01857
carboxypeptidase a1 precursor (ec 3.4.17.1). [swissprot;acc:p15085]	1329	CPA1		187.586	183.516	1.02218
	1422		High confidence	203.979	208.229	1.02084
carboxypeptidase a4 precursor (ec 3.4.17.-) (carboxypeptidase a3). [swissprot;acc:q9ui42]	2760	CPA4	Low confidence	195.28	191.932	1.01744
carboxypeptidase a5. [refseq;acc:nm_080385]	1349	CPA5		187.671	183.613	1.0221
	1417		High confidence	203.979	208.229	1.02084
carboxypeptidase b precursor (ec 3.4.17.2) (pancreas-specific protein) (pasp). [swissprot;acc:p15086]	1352	CPB1	Low confidence	187.651	183.595	1.02209
	1418		High confidence	203.979	208.229	1.02084
carboxypeptidase b precursor. [refseq;acc:nm_020361]	509	CPA6		177.698	190.239	1.07057
	3976		Low confidence	192.47	190.192	1.01198
carboxypeptidase d precursor (ec 3.4.17.-) (gp180). [swissprot;acc:o75976]	1	CPD		16	32	2
carboxypeptidase h precursor (ec 3.4.17.10) (cph) (carboxypeptidase e) (cpe) (enkephalin convertase) (prohormone processing carboxypeptidase). [swissprot;acc:p16870]	717	CPE	High confidence	223.121	211.685	1.05402
	3381		Low confidence	201.399	198.351	1.01537

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.