MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	Hugo	description	Network Comparison Type	Value Type	Interaction Map	Filtered	red	network_comparison	green

Results: HTML CSV LaTeX

Showing element 1201 to 1250 of 6456 in total

Value Type  : Ranked
Interaction Map  : High confidence
Filtered  : 1

Rank	Hugo	description	Network Comparison Type	red	network_comparison	green
601	FYN	proto-oncogene tyrosine-protein kinase fyn (ec 2.7.1.112) (p59-fyn) (syn) (slk). [swissprot;acc:p06241]	Subtracted	207.26	12.914	194.346
	VPS39	vam6/vps39-like protein (hvam6p). [swissprot;acc:q96jc1]	Divided	206.274	1.06069	218.792
602	FGR	proto-oncogene tyrosine-protein kinase fgr (ec 2.7.1.112) (p55-fgr) (c-fgr). [swissprot;acc:p09769]	Subtracted	207.26	12.914	194.346
	MAP4	microtubule-associated protein 4 (map 4). [swissprot;acc:p27816]	Divided	206.274	1.06069	218.792
603	CUTL1	ccaat displacement protein (cdp) (cut-like 1). [swissprot;acc:p39880]	Subtracted	207.27	12.902	194.368
	LEF1	lymphoid enhancer binding factor 1 (lef-1) (t cell-specific transcription factor 1-alpha) (tcf1-alpha). [swissprot;acc:q9uju2]	Divided	225.829	1.0605	212.945
604	CUTL2	homeobox protein cux-2 (cut-like 2) (fragment). [swissprot;acc:o14529]	Subtracted	207.272	12.901	194.371
	RPL15	60s ribosomal protein l15. [swissprot;acc:p39030]	Divided	217.862	1.0602	230.978
605	HIST1H2BL	histone h2b.c (h2b/c). [swissprot;acc:q99880]		247.47	1.0601	233.441
	LEF1	lymphoid enhancer binding factor 1 (lef-1) (t cell-specific transcription factor 1-alpha) (tcf1-alpha). [swissprot;acc:q9uju2]	Subtracted	225.829	12.884	212.945
606	HIST2H2BA	histone h2b.q (h2b/q) (h2b-gl105). [swissprot;acc:q16778]	Divided	247.47	1.0601	233.441
	WASL	neural wiskott-aldrich syndrome protein (n-wasp). [swissprot;acc:o00401]	Subtracted	207.309	12.857	194.452
607	no value	histone h3.1 (h3/a) (h3/c) (h3/d) (h3/f) (h3/h) (h3/i) (h3/j) (h3/k) (h3/l). [swissprot;acc:p16106]	Divided	247.47	1.0601	233.441
	SCOC	short coiled-coil protein; short coiled coil protein. [refseq;acc:nm_032547]	Subtracted	216.731	12.818	229.549
608	no value	histone h2b. [refseq;acc:nm_175055]	Divided	247.47	1.0601	233.441
	DYNLL2	dynein light chain 2. [refseq;acc:nm_080677]	Subtracted	216.731	12.818	229.549
609	no value	dead-box protein abstrakt homolog. [swissprot;acc:q9ujv9]		226.523	12.737	213.786
		histone h2b.s (h2b/s). [swissprot;acc:p57053]	Divided	247.47	1.0601	233.441
610		histone h2b.d (h2b/d). [swissprot;acc:q99877]
	SOS1	son of sevenless protein homolog 1 (sos-1). [swissprot;acc:q07889]	Subtracted	205.74	12.719	193.021
611	no value	u6 snrna-associated sm-like protein lsm7. [swissprot;acc:q9uk45]		228.986	12.71	216.276
	HIST3H3	histone h3.4 (h3t) (h3/t) (h3/g). [swissprot;acc:q16695]	Divided	247.47	1.0601	233.441
612	HIST1H2BA	testis-specific histone h2b; h2b histone family, member u, (testis-specific). [refseq;acc:nm_170610]
	SOS2	son of sevenless protein homolog 2 (sos-2). [swissprot;acc:q07890]	Subtracted	205.89	12.707	193.183
613	no value	histone h2b.e (h2b/e). [swissprot;acc:q99879]	Divided	247.47	1.0601	233.441
	NOL5A	nucleolar protein nop56 (nucleolar protein 5a). [swissprot;acc:o00567]	Subtracted	247.769	12.695	235.074
614	HOXA10	homeobox protein hox-a10 (hox-1h) (hox-1.8) (pl). [swissprot;acc:p31260]	Divided	214.257	1.06002	202.125
	YARS	tyrosyl-trna synthetase (ec 6.1.1.1) (tyrosyl--trna ligase) (tyrrs). [swissprot;acc:p54577]	Subtracted	232.468	12.58	245.048
615	HOXB9	homeobox protein hox-b9 (hox-2e) (hox-2.5). [swissprot;acc:p17482]	Divided	214.257	1.05999	202.132
	POLE	dna polymerase epsilon, catalytic subunit a (ec 2.7.7.7) (dna polymerase ii subunit a). [swissprot;acc:q07864]	Subtracted	241.907	12.557	229.35
616	CPA3	mast cell carboxypeptidase a precursor (ec 3.4.17.1) (mc-cpa) (carboxypeptidase a3). [swissprot;acc:p15088]		177.698	12.542	190.24
	HOXA9	homeobox protein hox-a9 (hox-1g). [swissprot;acc:p31269]	Divided	214.257	1.05999	202.132
617	CPA6	carboxypeptidase b precursor. [refseq;acc:nm_020361]	Subtracted	177.698	12.541	190.239
	HOXC9	homeobox protein hox-c9 (hox-3b). [swissprot;acc:p31274]	Divided	214.257	1.05997	202.135
618	CPB2	plasma carboxypeptidase b2 isoform a preproprotein; carboxypeptidase u; thrombin-activatable fibrinolysis inhibitor; carboxypeptidase b-like protein; thrombin-activable fibrinolysis inhibitor. [refseq;acc:nm_001872]	Subtracted	177.699	12.541	190.24
	GABRG3	gamma-aminobutyric-acid receptor gamma-3 subunit precursor (gaba(a) receptor). [swissprot;acc:q99928]	Divided	214.256	1.05994	202.139
619	FOXG1	forkhead box protein g1c (forkhead-related protein fkhl3) (hfk3) (fragment). [swissprot;acc:q14488]
	VPS39	vam6/vps39-like protein (hvam6p). [swissprot;acc:q96jc1]	Subtracted	206.274	12.518	218.792
620	GABRG1	gamma-aminobutyric-acid receptor gamma-1 subunit precursor (gaba(a) receptor). [swissprot;acc:q8n1c3]	Divided	214.256	1.05994	202.14
	MAP4	microtubule-associated protein 4 (map 4). [swissprot;acc:p27816]	Subtracted	206.274	12.518	218.792
621	GABRA2	gamma-aminobutyric-acid receptor alpha-2 subunit precursor (gaba(a) receptor). [swissprot;acc:p47869]	Divided	214.256	1.05994	202.14
	RPLP2	60s acidic ribosomal protein p2. [swissprot;acc:p05387]	Subtracted	231.92	12.515	244.435
622	GABRA6	gamma-aminobutyric-acid receptor alpha-6 subunit precursor (gaba(a) receptor). [swissprot;acc:q16445]	Divided	214.256	1.05994	202.14
	SYN3	synapsin iii. [swissprot;acc:o14994]	Subtracted	229.072	12.496	216.576
623	no value	aspartate beta-hydroxylase isoform b; junctin isoform 1; junctate; aspartyl/asparaginyl-beta-hydroxylase; peptide-aspartate beta-dioxygenase; humbug. [refseq;acc:nm_032468]
	GABRG2	gamma-aminobutyric-acid receptor gamma-2 subunit precursor (gaba(a) receptor). [swissprot;acc:p18507]	Divided	214.256	1.05994	202.14
624	no value	interleukin-1 receptor-associated kinase 4; interleukin-1 receptor associated kinase 4. [refseq;acc:nm_016123]				202.139
	HEY1	hairy/enhancer-of-split related with yrpw motif 1 (hairy and enhancer of split related-1) (hesr-1) (cardiovascular helix-loop-helix factor 2) (hes-related repressor protein 2 herp2). [swissprot;acc:q9y5j3]	Subtracted	229.072	12.496	216.576
625	ABLIM2	actin binding lim protein 2. [refseq;acc:nm_032432]
	GABRA4	gamma-aminobutyric-acid receptor alpha-4 subunit precursor (gaba(a) receptor). [swissprot;acc:p48169]	Divided	214.256	1.05994	202.14

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.