MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	Hugo	description	Value Type	Network Comparison Type	Interaction Map	Filtered	red	network_comparison	green

Results: HTML CSV LaTeX

Showing element 1201 to 1250 of 25824 in total

Interaction Map  : High confidence
Filtered  : 1

Rank	Hugo	description	Value Type	Network Comparison Type	red	network_comparison	green
151	CHRAC1	chromatin accessibility complex protein 1 (chrac-1) (chrac-15) (huchrac15) (dna polymerase epsilon subunit p15). [swissprot;acc:q9nrg0]	Rooted	Divided	38.8223	1.1977	46.4975
	CLP1	pre-mrna cleavage complex ii protein clp1. [swissprot;acc:q92989]	Measured	Subtracted	14830.5	1780.2	13050.3
	DNASE2B	deoxyribonuclease ii beta isoform 1 precursor; deoxyribonuclease ii beta; endonuclease dlad. [refseq;acc:nm_021233]	Squared	Divided	250303	1.41786	354894
	EPHX1	epoxide hydrolase 1 (ec 3.3.2.3) (microsomal epoxide hydrolase) (epoxide hydratase). [swissprot;acc:p07099]		Subtracted	87971.9	18408.8	69563.1
	HOMER2	homer, neuronal immediate early gene, 2; homer homolog 3 (drosophila). [refseq;acc:nm_004839]	Rooted		50.3065	12.6723	62.9788
	MYO5C	myosin vc (myosin 5c). [swissprot;acc:q9nqx4]	Ranked	Divided	55	1.19565	46
	PRMT8	protein arginine n-methyltransferase 4 (ec 2.1.1.-). [swissprot;acc:q9nr22]		Subtracted	226.582	28.138	198.444
	SH2D3C	sh2 domain containing 3c; novel sh2-containing protein 3; sh2 domain-containing 3c; likely ortholog of mouse cas/hef1-associated signal transducer. [refseq;acc:nm_005489]	Measured	Divided	4578.09	1.29746	5939.91
152	no value	myosin va (myosin 5a) (dilute myosin heavy chain, non-muscle) (myosin heavy chain 12) (myoxin). [swissprot;acc:q9y4i1]	Ranked		55	1.19565	46
	COQ7	ubiquinone biosynthesis protein coq7 homolog (coenzyme q biosynthesis protein 7 homolog) (timing protein clk-1 homolog). [swissprot;acc:q99807]	Rooted	Subtracted	50.3247	12.6645	62.9892
	HMG20B	high-mobility group 20b; sox-like transcriptional factor; swi/snf-related matrix-associated actin-dependent regulator of chromatin subfamily e, member 1-related. [refseq;acc:nm_006339]	Measured		5136.78	1759.2	6895.98
	LUC7L2	luc7-like 2; cgi-74 protein; cgi-59 protein. [refseq;acc:nm_016019]	Rooted	Divided	55.2859	1.19251	65.9288
	MAGED4	melanoma antigen, family d, 4 isoform 1; mage1 protein; mage-e1 protein; maged4 protein. [refseq;acc:nm_030801]	Measured		23693.7	1.29736	18263
	SEPT8	septin-like protein kiaa0202 (fragment). [swissprot;acc:q92599]	Squared		90226	1.4069	126939
	SLC15A1	oligopeptide transporter, small intestine isoform (peptide transporter 1) (intestinal h+/peptide cotransporter) (solute carrier family 15, member 1). [swissprot;acc:p46059]		Subtracted	73995.1	17991.4	56003.7
	SNRP70	u1 small nuclear ribonucleoprotein 70 kda (u1 snrnp 70 kda) (snrnp70) (u1-70k). [swissprot;acc:p08621]	Ranked		226.582	28.138	198.444
153	no value	filamin a (alpha-filamin) (filamin 1) (endothelial actin-binding protein) (abp-280) (nonmuscle filamin). [swissprot;acc:p21333]
		myosin heavy chain, cardiac muscle alpha isoform (myhc-alpha). [swissprot;acc:p13533]	Measured		9035	1755.4	7279.6
		ret finger protein 2 (leukemia associated protein 5) (b-cell chronic lymphocytic leukemia tumor suppressor leu5) (putative tumor suppressor rfp2) (tripartite motif protein 13). [swissprot;acc:o60858]	Squared	Divided	70011	1.40632	49783
	HOMER1	homer, neuronal immediate early gene, 1b. [refseq;acc:nm_004272]	Rooted	Subtracted	50.3333	12.6609	62.9942
	LUC7L	luc7-like; sarcoplasmic reticulum protein luc7b1. [refseq;acc:nm_018032]		Divided	55.297	1.19217	65.9236
	MAGEE2	hepatocellular carcinoma-associated protein hca3. [refseq;acc:nm_138703]	Measured		23693.7	1.29736	18263
	RBM15B	chromosome 3p21.1 gene sequence. [refseq;acc:nm_013286]	Ranked		249.663	1.19466	298.263
	SLC15A2	oligopeptide transporter, kidney isoform (peptide transporter 2) (kidney h+/peptide cotransporter) (solute carrier family 15, member 2). [swissprot;acc:q16348]	Squared	Subtracted	73510.2	17902.9	55607.3
154	no value	melanoma-associated antigen 3 (mage-3 antigen) (antigen mz2-d). [swissprot;acc:p43357]	Measured	Divided	23693.7	1.29736	18263
	CCT3	t-complex protein 1, gamma subunit (tcp-1-gamma) (cct-gamma). [swissprot;acc:p49368]	Squared		42788.3	1.40605	60162.6
	EIF5	eukaryotic translation initiation factor 5 (eif-5). [swissprot;acc:p55010]	Rooted		43.5479	1.18369	51.5473
	HOMER3	homer, neuronal immediate early gene, 3. [refseq;acc:nm_004838]		Subtracted	50.339	12.6585	62.9975
	MSI2	musashi 2 isoform a. [refseq;acc:nm_138962]	Ranked		227.491	28.033	199.458
	MYH4	myosin heavy chain, skeletal muscle, fetal (myosin heavy chain iib) (myhc-iib). [swissprot;acc:q9y623]	Measured		9035	1755.4	7279.6
	RGS19	regulator of g-protein signaling 19 (rgs19) (g-alpha interacting protein) (gaip protein). [swissprot;acc:p49795]	Ranked	Divided	249.663	1.19466	298.263
	SLC4A1AP	solute carrier family 4 (anion exchanger), member 1, adaptor protein; kidney anion exchanger adaptor protein; kanadaptin; lung cancer oncogene 3. [refseq;acc:nm_018158]	Squared	Subtracted	70525.9	17847.2	52678.7
155	CKS2	cyclin-dependent kinases regulatory subunit 2 (cks-2). [swissprot;acc:p33552]
	CSTF2	cleavage stimulation factor, 64 kda subunit (cstf 64 kda subunit) (cf-1 64 kda subunit). [swissprot;acc:p33240]		Divided	126408	1.40546	89940.5
	MAGEA11	melanoma-associated antigen 11 (mage-11 antigen). [swissprot;acc:p43364]	Measured		23693.7	1.29736	18263
	MSI1	musashi 1. [refseq;acc:nm_002442]	Ranked	Subtracted	227.491	28.033	199.458
	MYH8	myosin heavy chain, skeletal muscle, perinatal (myhc-perinatal). [swissprot;acc:p13535]	Measured		9035	1755.4	7279.6
	NCBP2L	dj820b18.1 (similar to nuclear cap binding protein) (fragment). [sptrembl;acc:q8wwk2]	Rooted		54.2343	12.498	66.7323
	RBM15	putative rna-binding protein 15 (rna binding motif protein 15) (one-twenty two protein). [swissprot;acc:q96t37]	Ranked	Divided	249.663	1.19466	298.263
	SNRPD2	small nuclear ribonucleoprotein sm d2 (snrnp core protein d2) (sm-d2). [swissprot;acc:p43330]	Rooted		55.7423	1.17835	65.6839
156	no value	formin binding protein 3; fas-ligand associated factor 1; huntingtin-interacting protein a; ny-ren-6 antigen. [refseq;acc:nm_017892]		Subtracted	55.1026	12.4675	67.5701
	CTNNAL1	catenin (cadherin-associated protein), alpha-like 1; alpha-catulin. [refseq;acc:nm_003798]	Squared		70525.9	17847.2	52678.7
	MAGEA2B	melanoma-associated antigen 2 (mage-2 antigen). [swissprot;acc:p43356]	Measured	Divided	23693.7	1.29736	18263
	MYH2	myosin heavy chain, skeletal muscle, adult 2 (myosin heavy chain iia) (myhc-iia). [swissprot;acc:q9ukx2]		Subtracted	9035	1755.4	7279.6
	RGS20	regulator of g-protein signaling 20 (rgs20) (regulator of gz- selective protein signaling 1) (gz-selective gtpase-activating protein) (g(z)gap). [swissprot;acc:o76081]	Ranked	Divided	249.663	1.19466	298.263
	SEPT10	septin 10 isoform 1. [refseq;acc:nm_144710]	Squared		89578.7	1.40528	125883
	SH2D3C	sh2 domain containing 3c; novel sh2-containing protein 3; sh2 domain-containing 3c; likely ortholog of mouse cas/hef1-associated signal transducer. [refseq;acc:nm_005489]	Rooted		56.3447	1.17356	66.124
	ZC3H14	nuclear protein ukp68. [refseq;acc:nm_024824]	Ranked	Subtracted	227.491	28.033	199.458
157	no value	hepatocellular carcinoma-associated protein hca1. [refseq;acc:nm_020932]	Measured	Divided	23693.7	1.29736	18263
		huntingtin-interacting protein hypa/fbp11 (fragment). [sptrembl;acc:o75404]	Rooted	Subtracted	55.1113	12.4424	67.5537

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.