MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	Hugo	description	Value Type	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 1186 to 1235 of 6456 in total

Value Type  : Ranked
Interaction Map  : High confidence
Filtered  : 1

Rank	Hugo	description	Network Comparison Type	red	green	network_comparison
593	HTATSF1	hiv tat specific factor 1; cofactor required for tat activation of hiv-1 transcription. [refseq;acc:nm_014500]	Subtracted	217.67	230.596	12.926
594	CDC40	pre-mrna splicing factor prp17 (hprp17) (eh-binding protein 3) (ehb3). [swissprot;acc:o60508]	Divided	223.282	210.136	1.06256
	CRK	proto-oncogene c-crk (p38) (adapter molecule crk). [swissprot;acc:p46108]	Subtracted	207.26	194.346	12.914
595	ABL2	tyrosine-protein kinase abl2 (ec 2.7.1.112) (tyrosine kinase arg). [swissprot;acc:p42684]
	VAV1	vav proto-oncogene. [swissprot;acc:p15498]	Divided	212.2	199.849	1.0618
596	no value	proto-oncogene tyrosine-protein kinase src (ec 2.7.1.112) (p60-src) (c-src). [swissprot;acc:p12931]	Subtracted	207.26	194.346	12.914
	VAV3	vav-3 protein. [swissprot;acc:q9ukw4]	Divided	212.253	199.908	1.06175
597	HCK	tyrosine-protein kinase hck (ec 2.7.1.112) (p59-hck/p60-hck) (hemopoietic cell kinase). [swissprot;acc:p08631]	Subtracted	207.26	194.346	12.914
	VAV2	vav-2 protein. [swissprot;acc:p52735]	Divided	212.526	200.212	1.0615
598	AKT1	rac-alpha serine/threonine kinase (ec 2.7.1.-) (rac-pk-alpha) (protein kinase b) (pkb) (c-akt). [swissprot;acc:p31749]		248.463	234.095	1.06138
	GRAP2	grb2-related adaptor protein 2 (gads protein) (growth factor receptor binding protein) (grblg) (grf40 adaptor protein) (grf-40) (grb-2-like protein) (grb2l) (grbx) (p38) (hematopoietic cell-associated adaptor protein grpl) (adapter protein grid) (sh3-sh2-sh3 adaptor mona). [swissprot;acc:o75791]	Subtracted	207.261	194.347	12.914
599	AKT3	rac-gamma serine/threonine protein kinase (ec 2.7.1.-) (rac-pk-gamma) (protein kinase akt-3) (protein kinase b, gamma) (pkb gamma) (stk-2). [swissprot;acc:q9y243]	Divided	248.463	234.095	1.06138
	CRKL	crk-like protein. [swissprot;acc:p46109]	Subtracted	207.26	194.346	12.914
600	ABL1	proto-oncogene tyrosine-protein kinase abl1 (ec 2.7.1.112) (p150) (c-abl). [swissprot;acc:p00519]
	AKT2	rac-beta serine/threonine protein kinase (ec 2.7.1.-) (rac-pk-beta) (protein kinase akt-2) (protein kinase b, beta) (pkb beta). [swissprot;acc:p31751]	Divided	248.463	234.095	1.06138
601	FYN	proto-oncogene tyrosine-protein kinase fyn (ec 2.7.1.112) (p59-fyn) (syn) (slk). [swissprot;acc:p06241]	Subtracted	207.26	194.346	12.914
	VPS39	vam6/vps39-like protein (hvam6p). [swissprot;acc:q96jc1]	Divided	206.274	218.792	1.06069
602	FGR	proto-oncogene tyrosine-protein kinase fgr (ec 2.7.1.112) (p55-fgr) (c-fgr). [swissprot;acc:p09769]	Subtracted	207.26	194.346	12.914
	MAP4	microtubule-associated protein 4 (map 4). [swissprot;acc:p27816]	Divided	206.274	218.792	1.06069
603	CUTL1	ccaat displacement protein (cdp) (cut-like 1). [swissprot;acc:p39880]	Subtracted	207.27	194.368	12.902
	LEF1	lymphoid enhancer binding factor 1 (lef-1) (t cell-specific transcription factor 1-alpha) (tcf1-alpha). [swissprot;acc:q9uju2]	Divided	225.829	212.945	1.0605
604	CUTL2	homeobox protein cux-2 (cut-like 2) (fragment). [swissprot;acc:o14529]	Subtracted	207.272	194.371	12.901
	RPL15	60s ribosomal protein l15. [swissprot;acc:p39030]	Divided	217.862	230.978	1.0602
605	HIST1H2BL	histone h2b.c (h2b/c). [swissprot;acc:q99880]		247.47	233.441	1.0601
	LEF1	lymphoid enhancer binding factor 1 (lef-1) (t cell-specific transcription factor 1-alpha) (tcf1-alpha). [swissprot;acc:q9uju2]	Subtracted	225.829	212.945	12.884
606	HIST2H2BA	histone h2b.q (h2b/q) (h2b-gl105). [swissprot;acc:q16778]	Divided	247.47	233.441	1.0601
	WASL	neural wiskott-aldrich syndrome protein (n-wasp). [swissprot;acc:o00401]	Subtracted	207.309	194.452	12.857
607	no value	histone h3.1 (h3/a) (h3/c) (h3/d) (h3/f) (h3/h) (h3/i) (h3/j) (h3/k) (h3/l). [swissprot;acc:p16106]	Divided	247.47	233.441	1.0601
	SCOC	short coiled-coil protein; short coiled coil protein. [refseq;acc:nm_032547]	Subtracted	216.731	229.549	12.818
608	no value	histone h2b. [refseq;acc:nm_175055]	Divided	247.47	233.441	1.0601
	DYNLL2	dynein light chain 2. [refseq;acc:nm_080677]	Subtracted	216.731	229.549	12.818
609	no value	dead-box protein abstrakt homolog. [swissprot;acc:q9ujv9]		226.523	213.786	12.737
		histone h2b.s (h2b/s). [swissprot;acc:p57053]	Divided	247.47	233.441	1.0601
610		histone h2b.d (h2b/d). [swissprot;acc:q99877]
	SOS1	son of sevenless protein homolog 1 (sos-1). [swissprot;acc:q07889]	Subtracted	205.74	193.021	12.719
611	no value	u6 snrna-associated sm-like protein lsm7. [swissprot;acc:q9uk45]		228.986	216.276	12.71
	HIST3H3	histone h3.4 (h3t) (h3/t) (h3/g). [swissprot;acc:q16695]	Divided	247.47	233.441	1.0601
612	HIST1H2BA	testis-specific histone h2b; h2b histone family, member u, (testis-specific). [refseq;acc:nm_170610]
	SOS2	son of sevenless protein homolog 2 (sos-2). [swissprot;acc:q07890]	Subtracted	205.89	193.183	12.707
613	no value	histone h2b.e (h2b/e). [swissprot;acc:q99879]	Divided	247.47	233.441	1.0601
	NOL5A	nucleolar protein nop56 (nucleolar protein 5a). [swissprot;acc:o00567]	Subtracted	247.769	235.074	12.695
614	HOXA10	homeobox protein hox-a10 (hox-1h) (hox-1.8) (pl). [swissprot;acc:p31260]	Divided	214.257	202.125	1.06002
	YARS	tyrosyl-trna synthetase (ec 6.1.1.1) (tyrosyl--trna ligase) (tyrrs). [swissprot;acc:p54577]	Subtracted	232.468	245.048	12.58
615	HOXB9	homeobox protein hox-b9 (hox-2e) (hox-2.5). [swissprot;acc:p17482]	Divided	214.257	202.132	1.05999
	POLE	dna polymerase epsilon, catalytic subunit a (ec 2.7.7.7) (dna polymerase ii subunit a). [swissprot;acc:q07864]	Subtracted	241.907	229.35	12.557
616	CPA3	mast cell carboxypeptidase a precursor (ec 3.4.17.1) (mc-cpa) (carboxypeptidase a3). [swissprot;acc:p15088]		177.698	190.24	12.542
	HOXA9	homeobox protein hox-a9 (hox-1g). [swissprot;acc:p31269]	Divided	214.257	202.132	1.05999
617	CPA6	carboxypeptidase b precursor. [refseq;acc:nm_020361]	Subtracted	177.698	190.239	12.541
	HOXC9	homeobox protein hox-c9 (hox-3b). [swissprot;acc:p31274]	Divided	214.257	202.135	1.05997
618	CPB2	plasma carboxypeptidase b2 isoform a preproprotein; carboxypeptidase u; thrombin-activatable fibrinolysis inhibitor; carboxypeptidase b-like protein; thrombin-activable fibrinolysis inhibitor. [refseq;acc:nm_001872]	Subtracted	177.699	190.24	12.541

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.