MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	Hugo	Value Type	Network Comparison Type	description	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 1162 to 1211 of 6456 in total

Value Type  : Ranked
Interaction Map  : High confidence
Filtered  : 1

Rank	Hugo	Network Comparison Type	description	red	green	network_comparison
581	TLX3	Divided	t-cell leukemia homeobox protein 3 (homeobox protein hox-11l2). [swissprot;acc:o43711]	237.28	252.492	1.06411
582	BARX1		homeobox protein barh-like 1. [swissprot;acc:q9hbu1]
	PSCD3	Subtracted	cytohesin 3 (arf nucleotide-binding site opener 3) (arno3 protein) (general receptor of phosphoinositides 1) (grp1). [swissprot;acc:o43739]	15	28	13
583	EIF4E		eukaryotic translation initiation factor 4e (eif-4e) (eif4e) (mrna cap-binding protein) (eif-4f 25 kda subunit). [swissprot;acc:p06730]	233.725	220.751	12.974
	OPN4	Divided	opsin 4 (melanopsin). [swissprot;acc:q9uhm6]	237.28	252.492	1.06411
584	BAIAP3	Subtracted	bai1-associated protein 3; bai-associated protein 3. [refseq;acc:nm_003933]	233.725	220.751	12.974
	TLX2	Divided	t-cell leukemia homeobox protein 2 (homeobox protein hox-11l1) (neural crest homeobox protein). [swissprot;acc:o43763]	237.28	252.492	1.06411
585	TLX1		t-cell leukemia homeobox protein 1 (homeobox protein hox-11) (tcl-3 proto-oncogene). [swissprot;acc:p31314]
	WAS	Subtracted	wiskott-aldrich syndrome protein (wasp). [swissprot;acc:p42768]	207.222	194.262	12.96
586	HECTD1	Divided	hect domain containing protein 1 (fragment). [swissprot;acc:q9ult8]	237.28	252.492	1.06411
	RRM1	Subtracted	ribonucleoside-diphosphate reductase m1 chain (ec 1.17.4.1) (ribonucleotide reductase large chain). [swissprot;acc:p23921]	217.215	204.279	12.936
587	BARX2	Divided	homeobox protein barh-like 2. [swissprot;acc:q9umq3]	237.28	252.492	1.06411
	HRB	Subtracted	nucleoporin-like protein rip (hiv-1 rev-binding protein) (rev interacting protein) (rev/rex activation domain-binding protein). [swissprot;acc:p52594]	217.67	230.596	12.926
588	no value		intersectin 1 (sh3 domain-containing protein 1a) (sh3p17). [swissprot;acc:q15811]
	SBDS	Divided	shwachman-bodian-diamond syndrome protein (cgi-97). [swissprot;acc:q9y3a5]	216.557	230.362	1.06375
589	no value		u6 snrna-associated sm-like protein lsm2 (small nuclear ribonuclear protein d homolog) (g7b) (snrnp core sm-like protein sm-x5). [swissprot;acc:q9y333]	228.215	214.546	1.06371
	PRAM1	Subtracted	pram-1 protein; pml-rara target gene encoding an adaptor molecule-1. [refseq;acc:nm_032152]	217.67	230.596	12.926
590	no value		intersectin 2 (sh3 domain-containing protein 1b) (sh3p18) (sh3p18-like wasp associated protein). [swissprot;acc:q9nzm3]
	RRM1	Divided	ribonucleoside-diphosphate reductase m1 chain (ec 1.17.4.1) (ribonucleotide reductase large chain). [swissprot;acc:p23921]	217.215	204.279	1.06333
591	HRBL	Subtracted	hiv-1 rev binding protein-like; rev/rex activation domain binding protein-related. [refseq;acc:nm_006076]	217.67	230.596	12.926
	RPP30	Divided	ribonuclease p protein subunit p30 (ec 3.1.26.5) (rnasep protein p30) (rnase p subunit 2). [swissprot;acc:p78346]	216.72	230.439	1.0633
592	C16orf35	Subtracted	cgthba protein (-14 gene protein). [swissprot;acc:q12980]	217.67	230.596	12.926
	PPP1R7	Divided	protein phosphatase 1, regulatory subunit 7; sds22. [refseq;acc:nm_002712]	91.63	97.4011	1.06298
593	DR1		tata-binding protein-associated phosphoprotein (down-regulator of transcription 1) (dr1 protein). [swissprot;acc:q01658]	232.118	218.406	1.06278
	HTATSF1	Subtracted	hiv tat specific factor 1; cofactor required for tat activation of hiv-1 transcription. [refseq;acc:nm_014500]	217.67	230.596	12.926
594	CDC40	Divided	pre-mrna splicing factor prp17 (hprp17) (eh-binding protein 3) (ehb3). [swissprot;acc:o60508]	223.282	210.136	1.06256
	CRK	Subtracted	proto-oncogene c-crk (p38) (adapter molecule crk). [swissprot;acc:p46108]	207.26	194.346	12.914
595	ABL2		tyrosine-protein kinase abl2 (ec 2.7.1.112) (tyrosine kinase arg). [swissprot;acc:p42684]
	VAV1	Divided	vav proto-oncogene. [swissprot;acc:p15498]	212.2	199.849	1.0618
596	no value	Subtracted	proto-oncogene tyrosine-protein kinase src (ec 2.7.1.112) (p60-src) (c-src). [swissprot;acc:p12931]	207.26	194.346	12.914
	VAV3	Divided	vav-3 protein. [swissprot;acc:q9ukw4]	212.253	199.908	1.06175
597	HCK	Subtracted	tyrosine-protein kinase hck (ec 2.7.1.112) (p59-hck/p60-hck) (hemopoietic cell kinase). [swissprot;acc:p08631]	207.26	194.346	12.914
	VAV2	Divided	vav-2 protein. [swissprot;acc:p52735]	212.526	200.212	1.0615
598	AKT1		rac-alpha serine/threonine kinase (ec 2.7.1.-) (rac-pk-alpha) (protein kinase b) (pkb) (c-akt). [swissprot;acc:p31749]	248.463	234.095	1.06138
	GRAP2	Subtracted	grb2-related adaptor protein 2 (gads protein) (growth factor receptor binding protein) (grblg) (grf40 adaptor protein) (grf-40) (grb-2-like protein) (grb2l) (grbx) (p38) (hematopoietic cell-associated adaptor protein grpl) (adapter protein grid) (sh3-sh2-sh3 adaptor mona). [swissprot;acc:o75791]	207.261	194.347	12.914
599	AKT3	Divided	rac-gamma serine/threonine protein kinase (ec 2.7.1.-) (rac-pk-gamma) (protein kinase akt-3) (protein kinase b, gamma) (pkb gamma) (stk-2). [swissprot;acc:q9y243]	248.463	234.095	1.06138
	CRKL	Subtracted	crk-like protein. [swissprot;acc:p46109]	207.26	194.346	12.914
600	ABL1		proto-oncogene tyrosine-protein kinase abl1 (ec 2.7.1.112) (p150) (c-abl). [swissprot;acc:p00519]
	AKT2	Divided	rac-beta serine/threonine protein kinase (ec 2.7.1.-) (rac-pk-beta) (protein kinase akt-2) (protein kinase b, beta) (pkb beta). [swissprot;acc:p31751]	248.463	234.095	1.06138
601	FYN	Subtracted	proto-oncogene tyrosine-protein kinase fyn (ec 2.7.1.112) (p59-fyn) (syn) (slk). [swissprot;acc:p06241]	207.26	194.346	12.914
	VPS39	Divided	vam6/vps39-like protein (hvam6p). [swissprot;acc:q96jc1]	206.274	218.792	1.06069
602	FGR	Subtracted	proto-oncogene tyrosine-protein kinase fgr (ec 2.7.1.112) (p55-fgr) (c-fgr). [swissprot;acc:p09769]	207.26	194.346	12.914
	MAP4	Divided	microtubule-associated protein 4 (map 4). [swissprot;acc:p27816]	206.274	218.792	1.06069
603	CUTL1	Subtracted	ccaat displacement protein (cdp) (cut-like 1). [swissprot;acc:p39880]	207.27	194.368	12.902
	LEF1	Divided	lymphoid enhancer binding factor 1 (lef-1) (t cell-specific transcription factor 1-alpha) (tcf1-alpha). [swissprot;acc:q9uju2]	225.829	212.945	1.0605
604	CUTL2	Subtracted	homeobox protein cux-2 (cut-like 2) (fragment). [swissprot;acc:o14529]	207.272	194.371	12.901
	RPL15	Divided	60s ribosomal protein l15. [swissprot;acc:p39030]	217.862	230.978	1.0602
605	HIST1H2BL		histone h2b.c (h2b/c). [swissprot;acc:q99880]	247.47	233.441	1.0601
	LEF1	Subtracted	lymphoid enhancer binding factor 1 (lef-1) (t cell-specific transcription factor 1-alpha) (tcf1-alpha). [swissprot;acc:q9uju2]	225.829	212.945	12.884
606	HIST2H2BA	Divided	histone h2b.q (h2b/q) (h2b-gl105). [swissprot;acc:q16778]	247.47	233.441	1.0601

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.