MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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description	Gene	Network Comparison Type	Value Type	Rank	Hugo	Interaction Map	red	Filtered	network_comparison	green

Results: HTML CSV LaTeX

Showing element 1144 to 1193 of 2060 in total

Network Comparison Type  : Subtracted
Interaction Map  : High confidence
red  : 0
Filtered  : 1
network_comparison  : 0
green  : 0

description	Value Type	Rank	Hugo
phosphoinositide-3-kinase, class 3; vps34; phosphatidylinositol 3-kinase, class 3. [refseq;acc:nm_002647]	Rooted	3173	PIK3C3
phosphoribosyl pyrophosphate synthetase-associated protein 1 (prpp synthetase-associated protein 1) (39 kda phosphoribosypyrophosphate synthetase-associated protein) (pap39). [swissprot;acc:q14558]	Measured	2869	PRPSAP1
	Ranked
	Squared
	Rooted
phosphoribosyl pyrophosphate synthetase-associated protein 2 (prpp synthetase-associated protein 2) (41 kda phosphoribosypyrophosphate synthetase-associated protein) (pap41). [swissprot;acc:o60256]	Measured	2943	PRPSAP2
	Ranked
	Squared
	Rooted
placenta growth factor precursor (plgf). [swissprot;acc:p49763]	Measured	3036	PGF
	Ranked
	Squared
	Rooted
placental protein 11 precursor (ec 3.4.21.-) (pp11). [swissprot;acc:p21128]	Measured	3076	no value
	Ranked
	Squared
	Rooted
platelet-activating factor acetylhydrolase ib alpha subunit (ec 3.1.1.47) (paf acetylhydrolase 45 kda subunit) (paf-ah 45 kda subunit) (paf-ah alpha) (pafah alpha) (lissencephaly-1 protein) (lis- 1). [swissprot;acc:p43034]	Measured	3221	PAFAH1B1
	Ranked
	Squared
	Rooted
pogo transposable element with znf domain isoform 1. [refseq;acc:nm_015100]	Measured	2932	POGZ
	Ranked
	Squared
	Rooted
polyhomeotic like 3; early development regulator 3; polyhomeotic 3. [refseq;acc:nm_024947]	Measured	2809	PHC3
	Ranked
	Squared
	Rooted
postsynaptic protein cript; hspc139 protein. [refseq;acc:nm_014171]	Measured	3034	CRIPT
	Ranked
	Squared
	Rooted
potassium channel tetramerisation domain containing 3; ny-ren-45 antigen. [refseq;acc:nm_016121]	Measured	2975	KCTD3
	Ranked
	Squared
	Rooted
prefoldin subunit 4 (protein c-1). [swissprot;acc:q9nqp4]	Measured	3130	PFDN4
	Ranked
	Squared
	Rooted
presenilin enhancer 2; hematopoietic stem/progenitor cells protein mds033. [refseq;acc:nm_172341]	Measured	3100	no value
	Ranked
	Squared
	Rooted
prkca-binding protein (protein kinase c-alpha binding protein) (protein interacting with c kinase 1). [swissprot;acc:q9nrd5]	Measured	3143	PICK1
	Ranked
	Squared
	Rooted
programmed cell death 10; apoptosis-related protein 15. [refseq;acc:nm_007217]	Measured	3052	PDCD10

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.