MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	description	Hugo	Value Type	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 1130 to 1179 of 6456 in total

Value Type  : Ranked
Interaction Map  : High confidence
Filtered  : 1

Rank	description	Hugo	Network Comparison Type	red	green	network_comparison
565	sedlin. [swissprot;acc:o14582]	ZNF547	Divided	129.219	121.261	1.06563
566	crooked neck-like protein 1 (crooked neck homolog) (hcrn) (cgi-201) (mstp021). [swissprot;acc:q9bzj0]	CRNKL1	Subtracted	220.744	207.121	13.623
	synbindin (trs23 homolog) (hematopoietic stem/progenitor cell protein 172) (hspc172) (ptd009) (cgi-104). [swissprot;acc:q9y296]	no value	Divided	129.219	121.261	1.06563
567	60s ribosomal protein l37 (g1.16). [swissprot;acc:p02403]	RPL37	Subtracted	228.639	242.258	13.619
	bet3 homolog. [swissprot;acc:o43617]	TRAPPC3	Divided	129.219	121.261	1.06563
568	putative pre-mrna splicing factor rna helicase (atp-dependent rna helicase #3) (deah-box protein 16). [swissprot;acc:o60231]	no value		226.3	212.38	1.06554
	splicing factor, arginine/serine-rich 1 (pre-mrna splicing factor sf2, p33 subunit) (alternative splicing factor asf-1). [swissprot;acc:q07955]	SFRS1	Subtracted	228.639	242.258	13.619
569	amidophosphoribosyltransferase precursor (ec 2.4.2.14) (glutamine phosphoribosylpyrophosphate amidotransferase) (atase) (gpat). [swissprot;acc:q06203]	PPAT
	t54 protein. [swissprot;acc:q92917]	GPKOW	Divided	226.3	212.38	1.06554
570	sorting nexin 17. [swissprot;acc:q15036]	SNX17	Subtracted	228.639	242.258	13.619
	splicing factor arginine/serine-rich 11 (arginine-rich 54 kda nuclear protein) (p54). [swissprot;acc:q05519]	SFRS11	Divided	229.709	215.631	1.06529
571	malate dehydrogenase, mitochondrial precursor (ec 1.1.1.37). [swissprot;acc:p40926]	MDH2		238.529	254.099	1.06528
	preimplantation protein 3; likely ortholog of preimplantation protein 3. [refseq;acc:nm_015387]	MOBKL3	Subtracted	221.807	208.264	13.543
572	cbf1 interacting corepressor. [refseq;acc:nm_004882]	no value	Divided	227.86	213.945	1.06504
	dnaj homolog subfamily b member 11 precursor (er-associated dnaj protein 3) (erj3) (er-associated hsp40 co-chaperone) (hdj9) (pwp1- interacting protein 4). [swissprot;acc:q9ubs4]	DNAJB11	Subtracted	221.807	208.264	13.543
573	autoantigen ngp-1. [swissprot;acc:q13823]	GNL2		250.302	236.817	13.485
	evolutionarily conserved g-patch domain containing. [refseq;acc:nm_018025]	GPATCH1	Divided	227.86	213.945	1.06504
574	dna-directed rna polymerase ii 16 kda polypeptide (ec 2.7.7.6) (rpb4). [swissprot;acc:o15514]	POLR2D	Subtracted	237.554	250.823	13.269
	preimplantation protein 3; likely ortholog of preimplantation protein 3. [refseq;acc:nm_015387]	MOBKL3	Divided	221.807	208.264	1.06503
575	dnaj homolog subfamily b member 11 precursor (er-associated dnaj protein 3) (erj3) (er-associated hsp40 co-chaperone) (hdj9) (pwp1- interacting protein 4). [swissprot;acc:q9ubs4]	DNAJB11
	pre-mrna splicing factor prp17 (hprp17) (eh-binding protein 3) (ehb3). [swissprot;acc:o60508]	CDC40	Subtracted	223.282	210.136	13.146
576	dj408b20.3 (novel protein similar to 60s acidic ribosomal protein p2 (rplp2)). [sptrembl;acc:q9h5a9]	no value	Divided	235.18	250.419	1.0648
	dna-directed rna polymerase ii 19 kda polypeptide (ec 2.7.7.6) (rpb7). [swissprot;acc:p52433]	POLR2G	Subtracted	232.469	245.613	13.144
577	60s ribosomal protein l15. [swissprot;acc:p39030]	RPL15		217.862	230.978	13.116
	enteropeptidase precursor (ec 3.4.21.9) (enterokinase). [swissprot;acc:p98073]	PRSS7	Divided	224.606	210.944	1.06477
578	mannosyl-oligosaccharide 1,2-alpha-mannosidase ib (ec 3.2.1.113) (processing alpha-1,2-mannosidase ib) (alpha-1,2-mannosidase ib) (mannosidase alpha class 1a member 2). [swissprot;acc:o60476]	no value	Subtracted	15	28	13
	splicing factor 3b subunit 2 (spliceosome associated protein 145) (sap 145) (sf3b150) (pre-mrna splicing factor sf3b 145 kda subunit). [swissprot;acc:q13435]	SF3B2	Divided	224.606	210.944	1.06477
579	cytohesin 1 (sec7 homolog b2-1). [swissprot;acc:q15438]	PSCD1	Subtracted	15	28	13
	zinc finger protein t86. [swissprot;acc:o00488]	ZNF593	Divided	246.805	231.796	1.06475
580	cytohesin 2 (arf nucleotide-binding site opener) (arno protein) (arf exchange factor). [swissprot;acc:q99418]	PSCD2	Subtracted	15	28	13
	zinc ribbon domain containing, 1; transcription-associated zinc ribbon protein; rna polymerase i small specific subunit rpa12. [refseq;acc:nm_014596]	ZNRD1	Divided	236.751	252.038	1.06457
581	cytohesin 4. [swissprot;acc:q9uia0]	PSCD4	Subtracted	15	28	13
	t-cell leukemia homeobox protein 3 (homeobox protein hox-11l2). [swissprot;acc:o43711]	TLX3	Divided	237.28	252.492	1.06411
582	cytohesin 3 (arf nucleotide-binding site opener 3) (arno3 protein) (general receptor of phosphoinositides 1) (grp1). [swissprot;acc:o43739]	PSCD3	Subtracted	15	28	13
	homeobox protein barh-like 1. [swissprot;acc:q9hbu1]	BARX1	Divided	237.28	252.492	1.06411
583	eukaryotic translation initiation factor 4e (eif-4e) (eif4e) (mrna cap-binding protein) (eif-4f 25 kda subunit). [swissprot;acc:p06730]	EIF4E	Subtracted	233.725	220.751	12.974
	opsin 4 (melanopsin). [swissprot;acc:q9uhm6]	OPN4	Divided	237.28	252.492	1.06411
584	bai1-associated protein 3; bai-associated protein 3. [refseq;acc:nm_003933]	BAIAP3	Subtracted	233.725	220.751	12.974
	t-cell leukemia homeobox protein 2 (homeobox protein hox-11l1) (neural crest homeobox protein). [swissprot;acc:o43763]	TLX2	Divided	237.28	252.492	1.06411
585	t-cell leukemia homeobox protein 1 (homeobox protein hox-11) (tcl-3 proto-oncogene). [swissprot;acc:p31314]	TLX1
	wiskott-aldrich syndrome protein (wasp). [swissprot;acc:p42768]	WAS	Subtracted	207.222	194.262	12.96
586	hect domain containing protein 1 (fragment). [swissprot;acc:q9ult8]	HECTD1	Divided	237.28	252.492	1.06411
	ribonucleoside-diphosphate reductase m1 chain (ec 1.17.4.1) (ribonucleotide reductase large chain). [swissprot;acc:p23921]	RRM1	Subtracted	217.215	204.279	12.936
587	homeobox protein barh-like 2. [swissprot;acc:q9umq3]	BARX2	Divided	237.28	252.492	1.06411
	nucleoporin-like protein rip (hiv-1 rev-binding protein) (rev interacting protein) (rev/rex activation domain-binding protein). [swissprot;acc:p52594]	HRB	Subtracted	217.67	230.596	12.926
588	intersectin 1 (sh3 domain-containing protein 1a) (sh3p17). [swissprot;acc:q15811]	no value
	shwachman-bodian-diamond syndrome protein (cgi-97). [swissprot;acc:q9y3a5]	SBDS	Divided	216.557	230.362	1.06375
589	pram-1 protein; pml-rara target gene encoding an adaptor molecule-1. [refseq;acc:nm_032152]	PRAM1	Subtracted	217.67	230.596	12.926
	u6 snrna-associated sm-like protein lsm2 (small nuclear ribonuclear protein d homolog) (g7b) (snrnp core sm-like protein sm-x5). [swissprot;acc:q9y333]	no value	Divided	228.215	214.546	1.06371
590	intersectin 2 (sh3 domain-containing protein 1b) (sh3p18) (sh3p18-like wasp associated protein). [swissprot;acc:q9nzm3]		Subtracted	217.67	230.596	12.926

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.