MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	description	Hugo	Value Type	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 1125 to 1174 of 3228 in total

Value Type  : Ranked
Network Comparison Type  : Divided
Interaction Map  : High confidence
Filtered  : 1

Rank	description	Hugo	red	green	network_comparison
1125	dj718p11.1.2 (novel class ii aminotransferase similar to serine palmotyltransferase (isoform 2)) (fragment). [sptrembl;acc:q9ugb5]	no value	204.404	210.022	1.02748
1126	atpase, h+ transporting, lysosomal 38kda, v0 subunit d isoform 2. [refseq;acc:nm_152565]	ATP6V0D2	218.487	212.656	1.02742
1127	nucleolar protein nop5 (nucleolar protein 5) (nop58) (hspc120). [swissprot;acc:q9y2x3]	no value	239.219	232.837	1.02741
1128	homeobox protein six1 (sine oculis homeobox homolog 1). [swissprot;acc:q15475]	SIX1	221.286	215.399	1.02733
1129	homeobox protein six2 (sine oculis homeobox homolog 2). [swissprot;acc:q9npc8]	SIX2	221.285	215.401	1.02732
1130	proliferation-associated protein 2g4 (cell cycle protein p38-2g4 homolog) (hg4-1). [swissprot;acc:q9uq80]	PA2G4		215.4
1131	vacuolar atp synthase subunit g 2 (ec 3.6.3.14) (v-atpase g subunit 2) (vacuolar proton pump g subunit 2) (v-atpase 13 kda subunit 2). [swissprot;acc:o95670]	no value	218.484	212.675	1.02731
1132	apoptosis inhibitor 5; fibroblast growth factor 2-interacting factor 2; api5-like 1. [refseq;acc:nm_006595]	API5
1133	sec13-related protein. [swissprot;acc:p55735]	SEC13
1134	vacuolar atp synthase subunit g 3 (ec 3.6.3.14) (v-atpase g subunit 3) (vacuolar proton pump g subunit 3) (v-atpase 13 kda subunit 3). [swissprot;acc:q96lb4]	ATP6V1G3
1135	vacuolar atp synthase subunit b, brain isoform (ec 3.6.3.14) (v-atpase b2 subunit) (vacuolar proton pump b isoform 2) (endomembrane proton pump 58 kda subunit) (ho57). [swissprot;acc:p21281]	ATP6V1B2
1136	yeast sec31p homolog. [refseq;acc:nm_014933]	SEC31A
1137	vacuolar atp synthase subunit g 1 (ec 3.6.3.14) (v-atpase g subunit 1) (vacuolar proton pump g subunit 1) (v-atpase 13 kda subunit 1) (vacuolar atp synthase subunit m16). [swissprot;acc:o75348]	ATP6V1G1
1138	vacuolar atp synthase subunit e (ec 3.6.3.14) (v-atpase e subunit) (vacuolar proton pump e subunit) (v-atpase 31 kda subunit) (p31). [swissprot;acc:p36543]	ATP6V1E1
1139	ganglioside-induced differentiation-associated protein 1-like 1. [refseq;acc:nm_024034]	GDAP1L1
1140	dead (asp-glu-ala-asp) box polypeptide 39 isoform 1; nuclear rna helicase, decd variant of dead box family. [refseq;acc:nm_005804]	DDX39
1141	ganglioside-induced differentiation-associated protein 1. [refseq;acc:nm_018972]	GDAP1
1142	vacuolar atp synthase subunit d (ec 3.6.3.14) (v-atpase d subunit) (vacuolar proton pump d subunit) (v-atpase 28 kda accessory protein). [swissprot;acc:q9y5k8]	ATP6V1D
1143	secretory pathway component sec31b-1. [refseq;acc:nm_015490]	SEC31B
1144	vacuolar atp synthase subunit h (ec 3.6.3.14) (v-atpase h subunit) (vacuolar proton pump h subunit) (v-atpase 50/57 kda subunits) (vacuolar proton pump subunit sfd) (cgi-11). [swissprot;acc:q9ui12]	ATP6V1H
1145	vacuolar atp synthase subunit f (ec 3.6.3.14) (v-atpase f subunit) (vacuolar proton pump f subunit) (v-atpase 14 kda subunit). [swissprot;acc:q16864]	ATP6V1F	218.481		1.0273
1146	vacuolar atp synthase subunit b, kidney isoform (ec 3.6.3.14) (v- atpase b1 subunit) (vacuolar proton pump b isoform 1) (endomembrane proton pump 58 kda subunit). [swissprot;acc:p15313]	ATP6V1B1	218.483	212.676
1147	peroxisomal membrane protein pex14 (peroxin-14) (peroxisomal membrane anchor protein pex14) (pts1 receptor docking protein). [swissprot;acc:o75381]	PEX14	208.651	203.109	1.02729
1148	ubiquitin. [swissprot;acc:p02248]	no value	209.061	203.518	1.02724
1149	bystin. [swissprot;acc:q13895]	BYSL	239.505	233.185	1.0271
1150	sorting nexin 1. [swissprot;acc:q13596]	SNX1	209.868	215.522	1.02694
1151	metaxin 1. [swissprot;acc:q13505]	MTX1	199.552	204.925	1.02693
1152	epidermal growth factor receptor pathway substrate 8-like protein 1 isoform c; epidermal growth factor receptor pathway substrate 8-related protein 1; eps8-related protein 1. [refseq;acc:nm_139204]	EPS8L1	221.939	216.143	1.02682
1153	epidermal growth factor receptor kinase substrate eps8. [swissprot;acc:q12929]	EPS8	221.93	216.146	1.02676
1154	inorganic pyrophosphatase (ec 3.6.1.1) (pyrophosphate phospho- hydrolase) (ppase). [swissprot;acc:q15181]	PPA1	224.307	230.242	1.02646
1155	inorganic pyrophosphatase 2 isoform 1. [refseq;acc:nm_176869]	PPA2
1156	aryl-hydrocarbon interacting protein-like 1. [swissprot;acc:q9nzn9]	AIPL1
1157	ah receptor-interacting protein (aip) (immunophilin homolog ara9) (hbv-x associated protein 2). [swissprot;acc:o00170]	AIP
1158	epidermal growth factor receptor pathway substrate 8-like protein 2; eps8-related protein 2; epidermal growth factor receptor pathway substrate 8-related protein 2. [refseq;acc:nm_022772]	EPS8L2	221.877	216.167	1.02641
1159	proline synthetase co-transcribed bacterial homolog protein. [swissprot;acc:o94903]	PROSC	170.28	165.898
1160	2-oxoglutarate dehydrogenase e1 component, mitochondrial precursor (ec 1.2.4.2) (alpha-ketoglutarate dehydrogenase). [swissprot;acc:q02218]	OGDH	208.55	214.041	1.02633
1161	kappa b-ras 1. [refseq;acc:nm_020345]	no value	220.758	215.097	1.02632
1162	i-kappa-b-interacting ras-like protein 2. [refseq;acc:nm_017595]	NKIRAS2
1163	snare associated protein snapin. [refseq;acc:nm_012437]	SNAPAP
1164	transducin-like enhancer protein 4. [swissprot;acc:q04727]	TLE4	219.438	213.818	1.02628
1165	transducin-like enhancer protein 3 (esg3). [swissprot;acc:q04726]	TLE3	219.401	213.785	1.02627
1166	transducin-like enhancer protein 2 (esg2). [swissprot;acc:q04725]	TLE2	219.374	213.759
1167	homeobox protein engrailed-2 (hu-en-2). [swissprot;acc:p19622]	EN2	219.399	213.784	1.02626
1168	cpg binding protein (protein containing phd finger and cxxc domain 1). [swissprot;acc:q9p0u4]	CXXC1
1169	activator of basal transcription 1; tata-binding protein-binding protein; basal transcriptional activator. [refseq;acc:nm_013375]	ABT1
1170	cytokine-like nuclear factor n-pac. [refseq;acc:nm_032569]	no value
1171	hect type e3 ubiquitin ligase. [refseq;acc:nm_015052]	HECW1
1172	transducin-like enhancer protein 1 (esg1). [swissprot;acc:q04724]	no value	219.375	213.767	1.02623
1173	candidate tumor suppressor in ovarian cancer 2. [refseq;acc:nm_080822]	DPH1	229.243	235.246	1.02619
1174	coatomer epsilon subunit (epsilon-coat protein) (epsilon-cop). [swissprot;acc:o14579]	COPE	187.964	192.849	1.02599

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.