MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Network Comparison Type	Rank	Gene	description	Hugo	Value Type	Interaction Map	Filtered	network_comparison	red	green

Results: HTML CSV LaTeX

Showing element 1108 to 1157 of 2061 in total

Network Comparison Type  : Subtracted
Interaction Map  : High confidence
Filtered  : 1
network_comparison  : 0
red  : 0
green  : 0

Rank	description	Hugo	Value Type
3032	similar to lysozyme c-1 (1,4-beta-n-acylmuramidase c, ec 3.2.1.17). [refseq;acc:nm_032517]	LYZL1	Rooted
3033	glycerol-3-phosphate acyltransferase, mitochondrial precursor (ec 2.3.1.15) (gpat). [swissprot;acc:q9hcl2]	GPAM	Measured
			Ranked
			Squared
			Rooted
3034	postsynaptic protein cript; hspc139 protein. [refseq;acc:nm_014171]	CRIPT	Measured
			Ranked
			Squared
			Rooted
3035	transforming growth factor beta 3 precursor (tgf-beta 3). [swissprot;acc:p10600]	TGFB3	Measured
			Ranked
			Squared
			Rooted
3036	placenta growth factor precursor (plgf). [swissprot;acc:p49763]	PGF	Measured
			Ranked
			Squared
			Rooted
3037	skd1 protein (vacuolar sorting protein 4b). [swissprot;acc:o75351]	VPS4B	Measured
			Ranked
			Squared
			Rooted
3038	spectrin alpha chain, brain (spectrin, non-erythroid alpha chain) (alpha-ii spectrin) (fodrin alpha chain). [swissprot;acc:q13813]	no value	Measured
			Ranked
			Squared
			Rooted
3039	set protein (hla-dr associated protein ii) (phapii) (phosphatase 2a inhibitor i2pp2a). [swissprot;acc:q01105]	SET	Measured
			Ranked
			Squared
			Rooted
3040	connective tissue growth factor precursor (hypertrophic chondrocyte- specific protein 24). [swissprot;acc:p29279]	CTGF	Measured
			Ranked
			Squared
			Rooted
3041	transthyretin precursor (prealbumin) (tbpa) (ttr) (attr). [swissprot;acc:p02766]	TTR	Measured
			Ranked
			Squared
			Rooted
3042	orphan nuclear receptor nr5a2 (alpha-1-fetoprotein transcription factor) (hepatocytic transcription factor) (b1-binding factor) (hb1f) (cyp7a promoter binding factor). [swissprot;acc:o00482]	NR5A2	Measured
			Ranked
			Squared
			Rooted
3043	transcription termination factor, rna polymerase ii; lodestar protein. [refseq;acc:nm_003594]	TTF2	Measured
			Ranked
			Squared
			Rooted
3044	late endosomal/lysosomal mp1 interacting protein (p14) (hspc003). [swissprot;acc:q9y2q5]	no value	Measured
			Ranked
			Squared
			Rooted
3045	dna mismatch repair protein msh6 (muts-alpha 160 kda subunit) (g/t mismatch binding protein) (gtbp) (gtmbp) (p160). [swissprot;acc:p52701]	MSH6	Measured

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.