MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	description	Value Type	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 1080 to 1129 of 12912 in total

Network Comparison Type  : Divided
Interaction Map  : High confidence
Filtered  : 1

Rank	description	Value Type	red	green	network_comparison
270	transcription factor iib. [refseq;acc:nm_013242]	Squared	64739.9	50300.6	1.28706
271	bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthethase 2 (paps synthethase 2) (papss 2) (sulfurylase kinase 2) (sk2) (sk 2) [includes: sulfate adenylyltransferase (ec 2.7.7.4) (sulfate adenylate transferase) (sat) (atp-sulfurylase); adenylylsulfate kinase (ec 2.7.1.25) (adenylylsulfate 3'-phosphotransferase) (aps kinase) (adenosine-5'-phosphosulfate 3'-phosphotransferase) (3'- phosphoadenosine-5'-phosphosulfate synthetase)]. [swissprot;acc:o95340]	Ranked	241.373	267.352	1.10763
	chromatin accessibility complex protein 1 (chrac-1) (chrac-15) (huchrac15) (dna polymerase epsilon subunit p15). [swissprot;acc:q9nrg0]	Measured	2554.89	3093.78	1.21092
	proto-oncogene tyrosine-protein kinase abl1 (ec 2.7.1.112) (p150) (c-abl). [swissprot;acc:p00519]	Rooted	66.1064	74.1073	1.12103
	splicing factor, arginine/serine-rich 8 (suppressor of white apricot protein homolog). [swissprot;acc:q12872]	Squared	64739.9	50300.6	1.28706
272	adrenodoxin, mitochondrial precursor (adrenal ferredoxin) (hepatoredoxin) (ferredoxin 1). [swissprot;acc:p10109]		36563.7	46971.1	1.28464
	histone acetyltransferase type b catalytic subunit (ec 2.3.1.48). [swissprot;acc:o14929]	Measured	3858.52	4669.27	1.21012
	ligatin (hepatocellular carcinoma-associated antigen 56). [swissprot;acc:p41214]	Ranked	241.373	267.352	1.10763
	proto-oncogene tyrosine-protein kinase fyn (ec 2.7.1.112) (p59-fyn) (syn) (slk). [swissprot;acc:p06241]	Rooted	66.1064	74.1074	1.12103
273	bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthethase 1 (paps synthethase 1) (papss 1) (sulfurylase kinase 1) (sk1) (sk 1) [includes: sulfate adenylyltransferase (ec 2.7.7.4) (sulfate adenylate transferase) (sat) (atp-sulfurylase); adenylylsulfate kinase (ec 2.7.1.25) (adenylylsulfate 3'-phosphotransferase) (aps kinase) (adenosine-5'-phosphosulfate 3'-phosphotransferase) (3'- phosphoadenosine-5'-phosphosulfate synthetase)]. [swissprot;acc:o43252]	Ranked	241.373	267.352	1.10763
	eukaryotic translation initiation factor 5 (eif-5). [swissprot;acc:p55010]	Measured	3199.4	3870.8	1.20985
	filamin b, beta (actin binding protein 278); beta filamin; filamin 1 (actin-binding protein-280)-like; filamin b, beta (actin-binding protein-278); filamin b, beta. [refseq;acc:nm_001457]	Squared	16120.1	20665.7	1.28198
	proto-oncogene tyrosine-protein kinase fgr (ec 2.7.1.112) (p55-fgr) (c-fgr). [swissprot;acc:p09769]	Rooted	66.1064	74.1074	1.12103
274	chromosome 3p21.1 gene sequence. [refseq;acc:nm_013286]	Measured	3119.98	2579.49	1.20953
	grb2-related adaptor protein 2 (gads protein) (growth factor receptor binding protein) (grblg) (grf40 adaptor protein) (grf-40) (grb-2-like protein) (grb2l) (grbx) (p38) (hematopoietic cell-associated adaptor protein grpl) (adapter protein grid) (sh3-sh2-sh3 adaptor mona). [swissprot;acc:o75791]	Rooted	66.1063	74.1068	1.12102
	nadph-cytochrome p450 reductase (ec 1.6.2.4) (cpr) (p450r). [swissprot;acc:p16435]	Ranked	241.373	267.352	1.10763
	rev1-like; rev1 protein; rev1 (yeast homolog)- like. [refseq;acc:nm_016316]	Squared	16120.1	20665.7	1.28198
275	ccaat displacement protein (cdp) (cut-like 1). [swissprot;acc:p39880]	Rooted	66.1048	74.0977	1.12091
	cholinephosphate cytidylyltransferase b (ec 2.7.7.15) (phosphorylcholine transferase b) (ctp:phosphocholine cytidylyltransferase b) (ct b) (cct b) (cct-beta). [swissprot;acc:q9y5k3]	Ranked	241.373	267.352	1.10763
	protein arginine n-methyltransferase 1 (ec 2.1.1.-) (interferon receptor 1-bound protein 4). [swissprot;acc:q99873]	Squared	16120.1	20665.7	1.28198
	regulator of g-protein signaling 19 (rgs19) (g-alpha interacting protein) (gaip protein). [swissprot;acc:p49795]	Measured	3119.98	2579.49	1.20953
276	60s ribosomal protein l32. [swissprot;acc:p02433]	Ranked	241.13	266.969	1.10716
	homeobox protein cux-2 (cut-like 2) (fragment). [swissprot;acc:o14529]	Rooted	66.1046	74.0964	1.1209
	protein arginine n-methyltransferase 4 (ec 2.1.1.-). [swissprot;acc:q9nr22]	Squared	16120.1	20665.7	1.28198
	putative rna-binding protein 15 (rna binding motif protein 15) (one-twenty two protein). [swissprot;acc:q96t37]	Measured	3119.98	2579.49	1.20953
277	40s ribosomal protein s29. [swissprot;acc:p30054]	Ranked	241.849	267.642	1.10665
	regulator of g-protein signaling 20 (rgs20) (regulator of gz- selective protein signaling 1) (gz-selective gtpase-activating protein) (g(z)gap). [swissprot;acc:o76081]	Measured	3119.98	2579.49	1.20953
	ribosomal protein s6 kinase, 52kda, polypeptide 1; ribosomal protein s6 kinase, 52kd, polypeptide 1. [refseq;acc:nm_012424]	Rooted	65.9938	73.9449	1.12048
	u1 small nuclear ribonucleoprotein 70 kda (u1 snrnp 70 kda) (snrnp70) (u1-70k). [swissprot;acc:p08621]	Squared	16120.1	20665.7	1.28198
278	40s ribosomal protein s11. [swissprot;acc:p04643]	Ranked	241.399	267.088	1.10642
	filamin a (alpha-filamin) (filamin 1) (endothelial actin-binding protein) (abp-280) (nonmuscle filamin). [swissprot;acc:p21333]	Squared	16120.1	20665.7	1.28198
	ribosomal protein s6 kinase-like 1. [refseq;acc:nm_031464]	Rooted	65.9938	73.9449	1.12048
	transcription factor lbx1. [swissprot;acc:p52954]	Measured	3119.98	2579.49	1.20953
279	histone acetyltransferase type b subunit 2 (retinoblastoma binding protein p46) (retinoblastoma-binding protein 7) (rbbp-7). [swissprot;acc:q16576]	Ranked	252.644	228.42	1.10605
	mosaic protein lgn. [swissprot;acc:p81274]	Measured	3119.98	2579.49	1.20953
	musashi 2 isoform a. [refseq;acc:nm_138962]	Squared	15569.5	19953.6	1.28158
	neural wiskott-aldrich syndrome protein (n-wasp). [swissprot;acc:o00401]	Rooted	66.0989	74.0609	1.12046
280	ba395l14.12 (novel protein similar to small nuclear ribonucleoprotein polypeptide a' (snrpa1)). [sptrembl;acc:q9nu36]		57.9068	64.8562	1.12001
	metastasis-associated protein mta1. [swissprot;acc:q13330]	Ranked	252.512	228.356	1.10578
	musashi 1. [refseq;acc:nm_002442]	Squared	15569.5	19953.6	1.28158
	regulator of g-protein signaling 17 (rgs17). [swissprot;acc:q9ugc6]	Measured	3119.98	2579.49	1.20953
281	60s ribosomal protein l17 (l23). [swissprot;acc:p18621]	Ranked	241.808	267.335	1.10557
	guanine nucleotide-binding protein g(o), alpha subunit 1. [swissprot;acc:p09471]	Measured	3119.98	2579.49	1.20953
	nuclear protein ukp68. [refseq;acc:nm_024824]	Squared	15569.5	19953.6	1.28158
	u2 small nuclear ribonucleoprotein a' (u2 snrnp-a'). [swissprot;acc:p09661]	Rooted	57.9068	64.8562	1.12001
282	chromatin assembly factor 1 subunit c (caf-1 subunit c) (chromatin assembly factor i p48 subunit) (caf-i 48 kda subunit) (caf-ip48) (retinoblastoma binding protein p48) (retinoblastoma-binding protein 4) (rbbp-4) (msi1 protein homolog). [swissprot;acc:q09028]	Ranked	252.39	228.297	1.10553
	rap1 gtpase-activating protein 1 (rap1gap). [swissprot;acc:p47736]	Measured	3119.98	2579.49	1.20953
	splicing factor 3a subunit 2 (spliceosome associated protein 62) (sap 62) (sf3a66). [swissprot;acc:q15428]	Rooted	57.9819	64.9302	1.11984
	stem cell growth factor; lymphocyte secreted c-type lectin; lymphocyte secreted c-type lectin. [refseq;acc:nm_002975]	Squared	59704	76460.4	1.28066
283	60s ribosomal protein l11. [swissprot;acc:p39026]	Ranked	241.828	267.346	1.10552

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.