MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Value Type	Gene	description	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 1062 to 1111 of 14920 in total

Network Comparison Type  : Divided
Interaction Map  : High confidence

Rank	Value Type	description	Filtered	red	green	network_comparison
133	Squared	metaxin 1. [swissprot;acc:q13505]	0	6149.89	3429.64	1.79316
	Rooted	odd-skipped related 1; odz (odd oz/ten-m) related 1. [refseq;acc:nm_145260]	1	45.4558	55.5995	1.22316
		tfiih basal transcription factor complex p44 subunit (basic transcription factor 2 44 kda subunit) (btf2-p44) (general transcription factor iih polypeptide 2). [swissprot;acc:q13888]	0	27.4578	22.8323	1.20259
134	Measured	gaba-a receptor-associated protein. [sptrembl;acc:q9by60]	1	21785.2	16426.1	1.32626
		mms19-like (met18 homolog, s. cerevisiae); homolog of yeast mms19; mms19 (met18 s. cerevisiae)-like. [refseq;acc:nm_022362]	0	260.986	346.751	1.32862
	Ranked	cytochrome p450 4f8 (ec 1.14.14.1) (cypivf8). [swissprot;acc:p98187]		12314.9	10489.3	1.17404
		dab2 interacting protein; ngap-like protein; doc-2/dab2 interactive protein. [refseq;acc:nm_032552]	1	350	290	1.2069
	Squared	aquaporin-cd (aqp-cd) (water channel protein for renal collecting duct) (adh water channel) (aquaporin 2) (collecting duct water channel protein) (wch-cd). [swissprot;acc:p41181]	0	11625.2	6483.52	1.79304
		p66 alpha. [refseq;acc:nm_017660]	1	81888.8	56306.5	1.45434
	Rooted	dead-box protein abstrakt homolog. [swissprot;acc:q9ujv9]	0	10	12	1.2
		dna polymerase epsilon p12 subunit (dna polymerase epsilon subunit 4). [swissprot;acc:q9nr33]	1	44.849	54.7964	1.2218
135	Measured	apg3p; pc3-96 protein. [refseq;acc:nm_022488]		21785.2	16426.1	1.32626
		rna polymerase i transcription factor rrn3. [refseq;acc:nm_018427]	0	814.485	613.614	1.32736
	Ranked	cytochrome p450 4f2 (ec 1.14.13.30) (cypivf2) (leukotriene-b4 omega- hydroxylase) (leukotriene-b4 20-monooxygenase) (cytochrome p450- ltb-omega). [swissprot;acc:p78329]		12314.9	10489.3	1.17404
		cytoplasmic polyadenylation element binding protein 4. [refseq;acc:nm_030627]	1	350	290	1.2069
	Squared	small glutamine rich protein with tetratricopeptide repeats 2. [refseq;acc:nm_019072]	0	21101.4	11769.5	1.79289
		transcription repressor p66 beta component of the mecp1 complex. [refseq;acc:nm_020699]	1	81888.8	56306.5	1.45434
	Rooted	20 kda nuclear cap binding protein (ncbp 20 kda subunit) (cbp20) (ncbp interacting protein 1) (nip1). [swissprot;acc:p52298]		54.935	66.6101	1.21253
		spectrin alpha chain, brain (spectrin, non-erythroid alpha chain) (alpha-ii spectrin) (fodrin alpha chain). [swissprot;acc:q13813]	0	42.8135	51.3517	1.19943
136	Measured	nuclear transcription factor y subunit gamma (nf-y protein chain c) (nuclear factor yc) (nf-yc) (ccaat-binding transcription factor subunit c) (cbf-c) (transactivator hsm-1/2). [swissprot;acc:q13952]	1	3620.77	4763.34	1.31556
		transcription factor e2f2 (e2f-2). [swissprot;acc:q14209]	0	1526.38	1150.51	1.3267
	Ranked	cytochrome p450 4f12 (ec 1.14.14.1) (cypivf12). [swissprot;acc:q9hcs2]		12335.3	10506.8	1.17403
		cytoplasmic polyadenylation element binding protein 3. [refseq;acc:nm_014912]	1	350	290	1.2069
	Squared	sorcin (22 kda protein) (cp-22) (v19). [swissprot;acc:p30626]	0	978.105	1746.18	1.78527
		tyrosine aminotransferase (ec 2.6.1.5) (l-tyrosine:2-oxoglutarate aminotransferase) (tat). [swissprot;acc:p17735]	1	81888.8	56306.5	1.45434
	Rooted	adiponectin receptor 2. [refseq;acc:nm_024551]		41.8357	50.6469	1.21061
		daz associated protein 1 isoform b; deleted in azoospermia associated protein 1. [refseq;acc:nm_018959]	0	23.9877	20.1222	1.1921
137	Measured	ccaat-binding transcription factor subunit b (cbf-b) (nf-y protein chain a) (nf-ya) (caat-box dna binding protein subunit a). [swissprot;acc:p23511]	1	3620.77	4763.34	1.31556
		heat shock factor binding protein 1. [swissprot;acc:o75506]	0	1631.18	1233.41	1.3225
	Ranked	cytochrome p450 4f11 (ec 1.14.14.1) (cypivf11). [swissprot;acc:q9hbi6]		12328.5	10501	1.17403
		ras gtpase-activating protein ngap (ras protein activator like 1). [swissprot;acc:q9ujf2]	1	350	290	1.2069
	Squared	cell division protein kinase 3 (ec 2.7.1.-). [swissprot;acc:q00526]		81606.8	56215.8	1.45167
		maspin precursor (protease inhibitor 5). [swissprot;acc:p36952]	0	0.417515	0.742249	1.77778
	Rooted	musashi 2 isoform a. [refseq;acc:nm_138962]	1	54.9787	66.2416	1.20486
		signal recognition particle 9 kda protein (srp9). [swissprot;acc:p49458]	0	18.9056	15.8624	1.19185
138	Measured	kv channel interacting protein 1; vesicle apc-binding protein; a-type potassium channel modulatory protein 1. [refseq;acc:nm_014592]	1	2755.15	2094.3	1.31555
		ubiquitin-conjugating enzyme e2-17 kda 3 (ec 6.3.2.19) (ubiquitin- protein ligase) (ubiquitin carrier protein) (e2(17)kb 3). [swissprot;acc:p47986]	0	204.382	154.804	1.32026
	Ranked	likely ortholog of rat cytochrome p450 4x1. [refseq;acc:nm_178033]		12384.7	10549.4	1.17397
		serine/threonine protein phosphatase 2a, catalytic subunit, alpha isoform (ec 3.1.3.16) (pp2a-alpha) (replication protein c) (rp-c). [swissprot;acc:p05323]	1	194.372	234.204	1.20493
	Squared	putative glialblastoma cell differentiation-related; putative glialblastoma cell differentiation-related protein. [refseq;acc:nm_016172]		468498	322755	1.45156
		serpin b11. [swissprot;acc:q96p15]	0	0.417515	0.742249	1.77778
	Rooted	inosine-5'-monophosphate dehydrogenase 2 (ec 1.1.1.205) (imp dehydrogenase 2) (impdh-ii) (impd 2). [swissprot;acc:p12268]		22.775	19.1245	1.19088
		musashi 1. [refseq;acc:nm_002442]	1	54.9787	66.2416	1.20486
139	Measured	associated molecule with the sh3 domain of stam (amsh) like protein. [refseq;acc:nm_020799]	0	736.737	561.038	1.31317
		potassium channel-interacting protein 4 isoform 4; calsenilin-like protein. [refseq;acc:nm_147183]	1	2759.61	2099.49	1.31442
	Ranked	alpha crystallin a chain. [swissprot;acc:p02489]	0	16372.4	13972.2	1.17178
		amyloid beta a4 precursor protein-binding family a member 1 (neuron- specific x11 protein) (neuronal munc18-1-interacting protein 1) (mint-1) (adapter protein x11alpha). [swissprot;acc:q02410]	1	271.752	225.68	1.20415
	Squared	cytoplasmic antiproteinase 2 (cap2) (cap-2) (protease inhibitor 8) (serpin b8). [swissprot;acc:p50452]	0	0.417515	0.742249	1.77778
		g2/mitotic-specific cyclin b2. [swissprot;acc:o95067]	1	81592.1	56211.1	1.45153
	Rooted	nuclear protein ukp68. [refseq;acc:nm_024824]		54.9787	66.2416	1.20486

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.