MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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description	Rank	Gene	Hugo	Value Type	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 1051 to 1100 of 6456 in total

Value Type  : Ranked
Interaction Map  : High confidence
Filtered  : 1

description	Rank	Hugo	Network Comparison Type	red	green	network_comparison
cbl e3 ubiquitin protein ligase (ec 6.3.2.-) (signal transduction protein cbl) (proto-oncogene c-cbl). [swissprot;acc:p22681]	762	CBL	Divided	213.256	203.237	1.0493
	769		Subtracted			10.019
ccaat displacement protein (cdp) (cut-like 1). [swissprot;acc:p39880]	556	CUTL1	Divided	207.27	194.368	1.06638
	603		Subtracted			12.902
ccaat-binding transcription factor subunit b (cbf-b) (nf-y protein chain a) (nf-ya) (caat-box dna binding protein subunit a). [swissprot;acc:p23511]	36	NFYA	Divided	260.532	204.309	1.27519
	64		Subtracted			56.223
ccaat-box-binding transcription factor (ccaat-binding factor) (cbf). [swissprot;acc:q03701]	349	CEBPZ		255.112	234.804	20.308
	408		Divided			1.08649
ccr4-not transcription complex, subunit 3; not3 (negative regulator of transcription 3, yeast) homolog. [refseq;acc:nm_014516]	3163	CNOT3		0.00001	0.00001	1
			Subtracted	0	0	0
ccr4-not transcription complex, subunit 4; not4 (negative regulator of transcription 4, yeast) homolog; ccr4-not transcription complex, subunit. [refseq;acc:nm_013316]	1337	CNOT4		218.47	213.875	4.595
	1390		Divided			1.02148
ccr4-not transcription complex, subunit 6-like. [refseq;acc:nm_144571]	2958	CNOT6L		0.00001	0.00001	1
			Subtracted	0	0	0
ccr4-not transcription complex, subunit 7 (ccr4-associated factor 1) (caf1) (btg1 binding factor 1). [swissprot;acc:q9uiv1]	3226	no value	Divided	0.00001	0.00001	1
			Subtracted	0	0	0
ccr4-not transcription complex, subunit 8 (caf1-like protein) (califp). [swissprot;acc:q9uff9]	2890	CNOT8	Divided	0.00001	0.00001	1
			Subtracted	0	0	0
cd109; gov system alloantigens on platelets. [refseq;acc:nm_133493]	2046	CD109		221.703	223.483	1.78
	2075		Divided			1.00803
cd209 antigen-like; putative type ii membrane protein. [refseq;acc:nm_014257]	364	CLEC4M	Subtracted	233.539	253.197	19.658
	418		Divided			1.08417
cd209 antigen; dendritic cell-specific icam3-grabbing nonintegrin. [refseq;acc:nm_021155]	366	CD209	Subtracted			19.658
	420		Divided			1.08417
cda11 protein. [refseq;acc:nm_032026]	1579	TATDN1		213.181	209.732	1.01644
	1587		Subtracted			3.449
cdc42 guanine exchange factor 9; hpem-2 collybistin. [refseq;acc:nm_015185]	1771	ARHGEF9		216.878	214.286	2.592
	1778		Divided			1.0121
cdc42-interacting protein 4 (thyroid receptor interacting protein 10) (trip-10). [swissprot;acc:q15642]	437	TRIP10		209.921	226.459	1.07878
			Subtracted			16.538
cdc5-like; cdc5 (cell division cycle 5, s. pombe, homolog)-like; cell division cycle 5, s. pombe, homolog-like; cdc5-related protein. [refseq;acc:nm_001253]	692	CDC5L	Divided	217.602	206.195	1.05532
	694		Subtracted			11.407
cdk-activating kinase assembly factor mat1 (ring finger protein mat1) (menage a trois) (cdk7/cyclin h assembly factor) (p36) (p35) (cyclin g1 interacting protein). [swissprot;acc:p51948]	3209	MNAT1	Divided	0.00001	0.00001	1
			Subtracted	0	0	0
cdp-diacylglycerol--inositol 3-phosphatidyltransferase (ec 2.7.8.11) (phosphatidylinositol synthase) (ptdins synthase) (pi synthase). [swissprot;acc:o14735]	2155	CDIPT	Divided	200.063	198.71	1.00681
	2218		Subtracted			1.353
cell adhesion molecule with homology to l1cam precursor; neural cell adhesion molecule; cell adhesion molecule l1-like; l1 cell adhesion molecule 2. [refseq;acc:nm_006614]	2739	CHL1	Divided	198.278	198.321	1.00022
			Subtracted			0.043
cell division control protein 2 homolog (ec 2.7.1.-) (p34 protein kinase) (cyclin-dependent kinase 1) (cdk1). [swissprot;acc:p06493]	1585	CDC2	Divided	168.145	170.888	1.01631
	1741		Subtracted			2.743
cell division cycle protein 23; anaphase-promoting complex subunit 8. [refseq;acc:nm_004661]	1481	CDC23	Divided	208.432	204.516	1.01915
	1495		Subtracted			3.916
cell division protein kinase 2 (ec 2.7.1.-) (p33 protein kinase). [swissprot;acc:p24941]	1583	CDK2	Divided	168.091	170.837	1.01634
	1739		Subtracted			2.746
cell division protein kinase 3 (ec 2.7.1.-). [swissprot;acc:q00526]	1581	CDK3	Divided	168.002	170.753	1.01637
	1736		Subtracted			2.751
cell division protein kinase 5 (ec 2.7.1.-) (tau protein kinase ii catalytic subunit) (tpkii catalytic subunit) (serine/threonine protein kinase pssalre). [swissprot;acc:q00535]	2850	CDK5	Divided	0.00001	0.00001	1
			Subtracted	0	0	0
cell division protein kinase 8 (ec 2.7.1.-) (protein kinase k35). [swissprot;acc:p49336]	2990	CDK8	Divided	0.00001	0.00001	1
			Subtracted	0	0	0

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.