MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	Hugo	Value Type	Network Comparison Type	description	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 1030 to 1079 of 6456 in total

Value Type  : Ranked
Interaction Map  : High confidence
Filtered  : 1

Rank	Hugo	Network Comparison Type	description	red	green	network_comparison
515	PES1	Divided	pescadillo homolog 1. [swissprot;acc:o00541]	251.297	234.941	1.06962
516	AKT3	Subtracted	rac-gamma serine/threonine protein kinase (ec 2.7.1.-) (rac-pk-gamma) (protein kinase akt-3) (protein kinase b, gamma) (pkb gamma) (stk-2). [swissprot;acc:q9y243]	248.463	234.095	14.368
	LSM8	Divided	u6 snrna-associated sm-like protein lsm8. [swissprot;acc:o95777]	228.255	213.422	1.0695
517	AKT2	Subtracted	rac-beta serine/threonine protein kinase (ec 2.7.1.-) (rac-pk-beta) (protein kinase akt-2) (protein kinase b, beta) (pkb beta). [swissprot;acc:p31751]	248.463	234.095	14.368
	MTX2	Divided	metaxin 2. [swissprot;acc:o75431]	219.537	234.793	1.06949
518	DVL1	Subtracted	segment polarity protein dishevelled homolog dvl-1 (dishevelled-1) (dsh homolog 1). [swissprot;acc:o14640]	218.596	204.344	14.252
	GNL3	Divided	nucleostemin; putative nucleotide binding protein, estradiol-induced. [refseq;acc:nm_014366]	250.858	234.563	1.06947
519	DVL2	Subtracted	segment polarity protein dishevelled homolog dvl-2 (dishevelled-2) (dsh homolog 2). [swissprot;acc:o14641]	218.613	204.382	14.231
	DVL3	Divided	segment polarity protein dishevelled homolog dvl-3 (dishevelled-3) (dsh homolog 3). [swissprot;acc:q92997]	218.702	204.582	1.06902
520	PRPF19	Subtracted	nuclear matrix protein nmp200 related to splicing factor prp19. [refseq;acc:nm_014502]	223.356	209.149	14.207
	SLC35D2	Divided	sqv-7-like protein (fragment). [sptrembl;acc:o95454]	214.754	229.565	1.06897
521	DVL3	Subtracted	segment polarity protein dishevelled homolog dvl-3 (dishevelled-3) (dsh homolog 3). [swissprot;acc:q92997]	218.702	204.582	14.12
	EXOSC4	Divided	exosome complex exonuclease rrp41 (ec 3.1.13.-) (ribosomal rna processing protein 41) (p12a). [swissprot;acc:q9npd3]	215.237	230.07	1.06891
522	PLRG1		pleiotropic regulator 1 (prl1homolog, arabidopsis); pleiotropic regulator 1 (prl1, arabidopsis homolog). [refseq;acc:nm_002669]	222.893	208.523
	SFRS11	Subtracted	splicing factor arginine/serine-rich 11 (arginine-rich 54 kda nuclear protein) (p54). [swissprot;acc:q05519]	229.709	215.631	14.078
523	EXOSC2	Divided	exosome complex exonuclease rrp4 (ec 3.1.13.-) (ribosomal rna processing protein 4). [swissprot;acc:q13868]	215.237	230.07	1.06891
	HIST1H2BL	Subtracted	histone h2b.c (h2b/c). [swissprot;acc:q99880]	247.47	233.441	14.029
524	EXOSC3	Divided	exosome complex exonuclease rrp40 (ec 3.1.13.-) (ribosomal rna processing protein 40) (p10) (cgi-102). [swissprot;acc:q9nqt5]	215.237	230.07	1.06891
	HIST2H2BA	Subtracted	histone h2b.q (h2b/q) (h2b-gl105). [swissprot;acc:q16778]	247.47	233.441	14.029
525	no value		histone h3.1 (h3/a) (h3/c) (h3/d) (h3/f) (h3/h) (h3/i) (h3/j) (h3/k) (h3/l). [swissprot;acc:p16106]
	EXOSC5	Divided	exosome complex exonuclease rrp46 (ec 3.1.13.-) (ribosomal rna processing protein 46) (p12b) (chronic myelogenous leukemia tumor antigen 28). [swissprot;acc:q9nqt4]	215.237	230.07	1.06891
526	no value	Subtracted	histone h2b. [refseq;acc:nm_175055]	247.47	233.441	14.029
	RRP1	Divided	nnp-1 protein (novel nuclear protein 1) (nucleolar protein nop52) (nop52) (d21s2056e). [swissprot;acc:p56182]	250.538	234.401	1.06884
527	no value	Subtracted	histone h2b.s (h2b/s). [swissprot;acc:p57053]	247.47	233.441	14.029
	DDX31	Divided	dead (asp-glu-ala-asp) box polypeptide 31 isoform 1; dead/dexh helicase ddx31. [refseq;acc:nm_022779]	248.56	232.579	1.06871
528	no value	Subtracted	histone h2b.d (h2b/d). [swissprot;acc:q99877]	247.47	233.441	14.029
	YME1L1	Divided	yme1-like 1 isoform 3; atp-dependent metalloprotease ftsh1 homolog. [refseq;acc:nm_014263]	222.146	237.393	1.06864
529	DDX18		atp-dependent rna helicase ddx18 (dead-box protein 18) (myc-regulated dead-box protein) (mrdb). [swissprot;acc:q9nvp1]	251.653	235.506	1.06856
	HIST3H3	Subtracted	histone h3.4 (h3t) (h3/t) (h3/g). [swissprot;acc:q16695]	247.47	233.441	14.029
530	HIST1H2BA		testis-specific histone h2b; h2b histone family, member u, (testis-specific). [refseq;acc:nm_170610]
	LSM6	Divided	u6 snrna-associated sm-like protein lsm6 (sm protein f). [swissprot;acc:q9y4y8]	227.483	212.994	1.06803
531	no value	Subtracted	histone h2b.e (h2b/e). [swissprot;acc:q99879]	247.47	233.441	14.029
	PRPF19	Divided	nuclear matrix protein nmp200 related to splicing factor prp19. [refseq;acc:nm_014502]	223.356	209.149	1.06793
532	no value	Subtracted	myosin heavy chain, cardiac muscle alpha isoform (myhc-alpha). [swissprot;acc:p13533]	112	126	14
	ZNF622	Divided	zinc finger-like protein 9. [refseq;acc:nm_033414]	250.942	235.004	1.06782
533	MRPS17	Subtracted	28s ribosomal protein s17, mitochondrial precursor (mrp-s17) (hspc011). [swissprot;acc:q9y2r5]	58	44	14
	SLC45A2	Divided	membrane-associated transporter protein (aim-1 protein) (melanoma antigen aim1). [swissprot;acc:q9umx9]	250.942	235.004	1.06782
534	no value		guanine nucleotide-binding protein-like 1 (gtp-binding protein hsr1). [swissprot;acc:p36915]
	PANK1	Subtracted	pantothenate kinase 1 (ec 2.7.1.33) (pantothenic acid kinase 1) (hpank1) (hpank). [swissprot;acc:q8te04]	58	44	14
535	MYH4		myosin heavy chain, skeletal muscle, fetal (myosin heavy chain iib) (myhc-iib). [swissprot;acc:q9y623]	112	126
	POLR2H	Divided	dna-directed rna polymerases i, ii, and iii 17.1 kda polypeptide (ec 2.7.7.6) (rpb17) (rpb8) (rpabc3). [swissprot;acc:p52434]	236.662	252.708	1.0678
536	MYH8	Subtracted	myosin heavy chain, skeletal muscle, perinatal (myhc-perinatal). [swissprot;acc:p13535]	112	126	14
	SSB	Divided	lupus la protein (sjogren syndrome type b antigen) (ss-b) (la ribonucleoprotein) (la autoantigen). [swissprot;acc:p05455]	242.531	227.136	1.06778
537	DHX15		putative pre-mrna splicing factor rna helicase (deah box protein 15) (atp-dependent rna helicase #46). [swissprot;acc:o43143]	229.803	215.301	1.06736
	UBAC1	Subtracted	putative glialblastoma cell differentiation-related; putative glialblastoma cell differentiation-related protein. [refseq;acc:nm_016172]	10	24	14
538	PANK2		pantothenate kinase 2, mitochondrial precursor (ec 2.7.1.33) (pantothenic acid kinase 2) (hpank2). [swissprot;acc:q9bz23]	58	44
	POLR2L	Divided	dna-directed rna polymerase ii 7.6 kda polypeptide (ec 2.7.7.6) (rpb10) (rpb7.6) (rpabc5). [swissprot;acc:p52436]	237.627	253.604	1.06724
539	MEMO1P		protein cgi-27 (c21orf19-like protein). [swissprot;acc:q9y316]	236.964	252.86	1.06708
	MYH2	Subtracted	myosin heavy chain, skeletal muscle, adult 2 (myosin heavy chain iia) (myhc-iia). [swissprot;acc:q9ukx2]	112	126	14
540	PANK3		pantothenate kinase 3 (ec 2.7.1.33) (pantothenic acid kinase 3) (hpank3). [swissprot;acc:q9h999]	58	44

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.