MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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description	Rank	Gene	Hugo	Network Comparison Type	Value Type	Interaction Map	Filtered	red	green	network_comparison

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Showing element 1025 to 1074 of 6456 in total

Value Type  : Ranked
Interaction Map  : High confidence
Filtered  : 1

description	Rank	Hugo	Network Comparison Type	red	green	network_comparison
casein kinase i, gamma 2 isoform (ec 2.7.1.-) (cki-gamma 2). [swissprot;acc:p78368]	2986	CSNK1G2	Divided	0.00001	0.00001	1
			Subtracted	0	0	0
casein kinase i, gamma 3 isoform (ec 2.7.1.-) (cki-gamma 3). [swissprot;acc:q9y6m4]	2901	CSNK1G3	Divided	0.00001	0.00001	1
			Subtracted	0	0	0
casein kinase ii beta chain (ck ii) (phosvitin) (g5a). [swissprot;acc:p13862]	885	no value		232.473	224.372	8.101
	936		Divided			1.03611
casein kinase ii, alpha chain (ck ii) (ec 2.7.1.37). [swissprot;acc:p19138]	810	CSNK2A1P	Subtracted	240.194	230.957	9.237
	863		Divided			1.03999
casein kinase ii, alpha' chain (ck ii) (ec 2.7.1.37). [swissprot;acc:p19784]	811	CSNK2A2	Subtracted			9.237
	864		Divided			1.03999
caspase-7 precursor (ec 3.4.22.-) (ice-like apoptotic protease 3) (ice-lap3) (apoptotic protease mch-3) (cmh-1). [swissprot;acc:p55210]	1165	CASP7	Subtracted	233.942	228.46	5.482
	1292		Divided			1.024
catenin (cadherin-associated protein), alpha-like 1; alpha-catulin. [refseq;acc:nm_003798]	1834	CTNNAL1		180.409	182.459	1.01136
	1956		Subtracted			2.05
cathepsin b precursor (ec 3.4.22.1) (cathepsin b1) (app secretase). [swissprot;acc:p07858]	1667	CTSB	Divided	214.898	211.898	1.01416
	1672		Subtracted			3
cathepsin l precursor (ec 3.4.22.15) (major excreted protein) (mep). [swissprot;acc:p07711]	1390	CTSL1		214.717	219.157	4.44
	1426		Divided			1.02068
cathepsin l2 precursor (ec 3.4.22.43) (cathepsin v) (cathepsin u). [swissprot;acc:o60911]	1389	CTSL2	Subtracted			4.44
	1425		Divided			1.02068
caveolin-1. [swissprot;acc:q03135]	3099	CAV1		0.00001	0.00001	1
			Subtracted	0	0	0
caveolin-3 (m-caveolin). [swissprot;acc:p56539]	2779	CAV3	Divided	0.00001	0.00001	1
			Subtracted	0	0	0
cbf1 interacting corepressor. [refseq;acc:nm_004882]	555	no value		227.86	213.945	13.915
	572		Divided			1.06504
cbl e3 ubiquitin protein ligase (ec 6.3.2.-) (signal transduction protein cbl) (proto-oncogene c-cbl). [swissprot;acc:p22681]	762	CBL		213.256	203.237	1.0493
	769		Subtracted			10.019
ccaat displacement protein (cdp) (cut-like 1). [swissprot;acc:p39880]	556	CUTL1	Divided	207.27	194.368	1.06638
	603		Subtracted			12.902
ccaat-binding transcription factor subunit b (cbf-b) (nf-y protein chain a) (nf-ya) (caat-box dna binding protein subunit a). [swissprot;acc:p23511]	36	NFYA	Divided	260.532	204.309	1.27519
	64		Subtracted			56.223
ccaat-box-binding transcription factor (ccaat-binding factor) (cbf). [swissprot;acc:q03701]	349	CEBPZ		255.112	234.804	20.308
	408		Divided			1.08649
ccr4-not transcription complex, subunit 3; not3 (negative regulator of transcription 3, yeast) homolog. [refseq;acc:nm_014516]	3163	CNOT3		0.00001	0.00001	1
			Subtracted	0	0	0
ccr4-not transcription complex, subunit 4; not4 (negative regulator of transcription 4, yeast) homolog; ccr4-not transcription complex, subunit. [refseq;acc:nm_013316]	1337	CNOT4		218.47	213.875	4.595
	1390		Divided			1.02148
ccr4-not transcription complex, subunit 6-like. [refseq;acc:nm_144571]	2958	CNOT6L		0.00001	0.00001	1
			Subtracted	0	0	0
ccr4-not transcription complex, subunit 7 (ccr4-associated factor 1) (caf1) (btg1 binding factor 1). [swissprot;acc:q9uiv1]	3226	no value	Divided	0.00001	0.00001	1
			Subtracted	0	0	0
ccr4-not transcription complex, subunit 8 (caf1-like protein) (califp). [swissprot;acc:q9uff9]	2890	CNOT8	Divided	0.00001	0.00001	1
			Subtracted	0	0	0
cd109; gov system alloantigens on platelets. [refseq;acc:nm_133493]	2046	CD109		221.703	223.483	1.78
	2075		Divided			1.00803
cd209 antigen-like; putative type ii membrane protein. [refseq;acc:nm_014257]	364	CLEC4M	Subtracted	233.539	253.197	19.658
	418		Divided			1.08417
cd209 antigen; dendritic cell-specific icam3-grabbing nonintegrin. [refseq;acc:nm_021155]	366	CD209	Subtracted			19.658
	420		Divided			1.08417

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.