MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	Value Type	description	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 201 to 250 of 8289 in total

Value Type  : Ranked
Network Comparison Type  : Divided
Filtered  : 1

Rank	description	Interaction Map	red	green	network_comparison
101	leucine zipper domain protein. [refseq;acc:nm_024589]	Low confidence	221.996	238.82	1.07579
	melanoma-associated antigen b1 (mage-b1 antigen) (mage-xp antigen) (dss-ahc critical interval mage superfamily 10) (dam10). [swissprot;acc:p43366]	High confidence	88.2482	110.265	1.24949
102	diacylglycerol kinase, theta (ec 2.7.1.107) (diglyceride kinase) (dgk- theta) (dag kinase theta). [swissprot;acc:p52824]	Low confidence	229.556	213.456	1.07543
	melanoma-associated antigen d2 (mage-d2 antigen) (breast cancer associated gene 1 protein) (bcg-1) (11b6) (hepatocellular carcinoma associated protein jcl-1). [swissprot;acc:q9unf1]	High confidence	88.2482	110.265	1.24949
103	trophinin. [swissprot;acc:q12816]
	vacuolar protein sorting 16 (hvps16). [swissprot;acc:q9h269]	Low confidence	203.948	189.652	1.07538
104	adiponectin receptor 2. [refseq;acc:nm_024551]		219.277	204.212	1.07377
	homer, neuronal immediate early gene, 2; homer homolog 3 (drosophila). [refseq;acc:nm_004839]	High confidence	252.371	202.016	1.24926
105	guanine nucleotide-binding protein g(i)/g(s)/g(t) beta subunit 1 (transducin beta chain 1). [swissprot;acc:p04901]		266.716	333.165	1.24914
	transcription factor e2f1 (e2f-1) (retinoblastoma binding protein 3) (rbbp-3) (prb-binding protein e2f-1) (pbr3) (retinoblastoma-associated protein 1) (rbap-1). [swissprot;acc:q01094]	Low confidence	220.497	205.364	1.07369
106	transcription factor e2f2 (e2f-2). [swissprot;acc:q14209]
	ubiquinone biosynthesis protein coq7 homolog (coenzyme q biosynthesis protein 7 homolog) (timing protein clk-1 homolog). [swissprot;acc:q99807]	High confidence	252.329	202.004	1.24913
107	homer, neuronal immediate early gene, 1b. [refseq;acc:nm_004272]		252.309	201.998	1.24907
	mouse mammary turmor virus receptor homolog 1. [refseq;acc:nm_152832]	Low confidence	227.429	211.97	1.07293
108	disks large-associated protein 3 (dap-3) (sap90/psd-95-associated protein 3) (sapap3) (psd-95/sap90 binding protein 3) (fragment). [swissprot;acc:o95886]		197.731	212.069	1.07251
	homer, neuronal immediate early gene, 3. [refseq;acc:nm_004838]	High confidence	252.296	201.995	1.24902
109	guanine nucleotide-binding protein beta subunit 4 (transducin beta chain 4). [swissprot;acc:q9hav0]		266.933	333.281	1.24856
	neuralized-like. [refseq;acc:nm_004210]	Low confidence	232.704	216.996	1.07239
110	deltex 2. [refseq;acc:nm_020892]	High confidence	333.144	267.393	1.2459
	disks large-associated protein 2 (dap-2) (sap90/psd-95-associated protein 2) (sapap2) (psd-95/sap90 binding protein 2) (fragment). [swissprot;acc:q9p1a6]	Low confidence	197.752	212.031	1.07221
111	deltex homolog 1; hdx-1. [refseq;acc:nm_004416]	High confidence	332.925	267.274	1.24563
	vacuolar protein sorting 33a (hvps33a). [swissprot;acc:q96ax1]	Low confidence	203.914	190.189	1.07217
112	cellular repressor of e1a-stimulated genes. [refseq;acc:nm_003851]		197.762	212.013	1.07206
	t-lak cell-originated protein kinase; spermatogenesis-related protein kinase; pdz-binding kinase; pbk; mapkk-like protein kinase; serine/threonine protein kinase. [refseq;acc:nm_018492]	High confidence	332.874	267.246	1.24557
113	cellular repressor of e1a-stimulated genes 2. [refseq;acc:nm_153836]	Low confidence	197.763	212.011	1.07205
	kh domain containing, rna binding, signal transduction associated 3; sam68-like phosphotyrosine protein, t-star. [refseq;acc:nm_006558]	High confidence	332.874	267.246	1.24557
114	disks large-associated protein 1 (dap-1) (guanylate kinase-associated protein) (hgkap) (sap90/psd-95-associated protein 1) (sapap1) (psd- 95/sap90 binding protein 1). [swissprot;acc:o14490]	Low confidence	197.779	211.983	1.07182
	kh domain containing, rna binding, signal transduction associated 1; gap-associated tyrosine phosphoprotein p62 (sam68). [refseq;acc:nm_006559]	High confidence	332.874	267.246	1.24557
115	disks large-associated protein 4 (dap-4) (sap90/psd-95-associated protein 4) (sapap4) (psd-95/sap90 binding protein 4). [swissprot;acc:q9y2h0]	Low confidence	197.779	211.983	1.07182
	kh domain-containing, rna-binding, signal transduction-associated protein 2; sam68-like mammalian protein 1. [refseq;acc:nm_152688]	High confidence	332.874	267.246	1.24557
116	guanine nucleotide-binding protein g(i)/g(s)/g(t) beta subunit 3 (transducin beta chain 3). [swissprot;acc:p16520]		268.565	334.483	1.24545
	vacuolar protein sorting 18 (hvps18). [swissprot;acc:q9p253]	Low confidence	204.161	190.791	1.07008
117	coagulation factor xiii a chain precursor (ec 2.3.2.13) (protein- glutamine gamma-glutamyltransferase a chain) (transglutaminase a chain). [swissprot;acc:p00488]		226.395	211.713	1.06935
	neuralized-like. [refseq;acc:nm_004210]	High confidence	332.326	266.948	1.24491
118	nadh-ubiquinone oxidoreductase subunit b17.2 (ec 1.6.5.3) (ec 1.6.99.3) (complex i-b17.2) (ci-b17.2) (cib17.2) (13 kda differentiation-associated protein). [swissprot;acc:q9ui09]		284.753	228.934	1.24382
	protein-glutamine gamma-glutamyltransferase k (ec 2.3.2.13) (transglutaminase k) (tgase k) (tgk) (tg(k)) (transglutaminase 1) (epidermal tgase). [swissprot;acc:p22735]	Low confidence	226.395	211.713	1.06935
119	nadh-ubiquinone oxidoreductase 18 kda subunit, mitochondrial precursor (ec 1.6.5.3) (ec 1.6.99.3) (complex i-18 kda) (ci-18 kda) (complex i- aqdq) (ci-aqdq). [swissprot;acc:o43181]	High confidence	318.982	259.004	1.23157
	natural resistance-associated macrophage protein 1 (nramp 1). [swissprot;acc:p49279]	Low confidence	225.666	211.107	1.06897
120	potassium voltage-gated channel, shal-related subfamily, member 2; voltage-sensitive potassium channel; voltage-gated potassium channel kv4.2. [refseq;acc:nm_012281]	High confidence	269.278	327.709	1.21699
	segment polarity protein dishevelled homolog dvl-1 (dishevelled-1) (dsh homolog 1). [swissprot;acc:o14640]	Low confidence	203.016	189.965	1.0687
121	cystathionine gamma-lyase (ec 4.4.1.1) (gamma-cystathionase). [swissprot;acc:p32929]	High confidence	269.254	327.655	1.2169
	segment polarity protein dishevelled homolog dvl-2 (dishevelled-2) (dsh homolog 2). [swissprot;acc:o14641]	Low confidence	203.007	189.985	1.06854
122	nanos (fragment). [sptrembl;acc:q8wy41]		203.66	217.479	1.06785
	potassium voltage-gated channel, shal-related subfamily, member 3 isoform 1; sha1-related potassium channel kv4.3; voltage-gated k+ channel; potassium ionic channel kv4.3; voltage-gated potassium channel kv4.3. [refseq;acc:nm_004980]	High confidence	269.248	327.642	1.21688
123	potassium voltage-gated channel, shal-related subfamily, member 1; shal-type potassium channel; voltage-gated potassium channel kv4.1. [refseq;acc:nm_004979]		269.23	327.601	1.21681
	segment polarity protein dishevelled homolog dvl-3 (dishevelled-3) (dsh homolog 3). [swissprot;acc:q92997]	Low confidence	202.96	190.094	1.06768
124	high-mobility group 20b; sox-like transcriptional factor; swi/snf-related matrix-associated actin-dependent regulator of chromatin subfamily e, member 1-related. [refseq;acc:nm_006339]	High confidence	208.52	171.595	1.21519
	natural resistance-associated macrophage protein 2 (nramp 2) (divalent metal transporter 1) (dmt1). [swissprot;acc:p49281]	Low confidence	224.763	210.566	1.06742
125	b9 protein; likely ortholog of mouse endothelial precursor protein b9. [refseq;acc:nm_015681]		213.243	227.616	1.0674
	high-mobility group 20a. [refseq;acc:nm_018200]	High confidence	208.588	171.778	1.21429

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.