MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	Network Comparison Type	Hugo	description	Value Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 1012 to 1061 of 6456 in total

Value Type  : Ranked
Interaction Map  : High confidence
Filtered  : 1

Rank	Network Comparison Type	Hugo	description	red	green	network_comparison
506	Subtracted	EXOSC4	exosome complex exonuclease rrp41 (ec 3.1.13.-) (ribosomal rna processing protein 41) (p12a). [swissprot;acc:q9npd3]	215.237	230.07	14.833
507	Divided	WDR12	wd-repeat protein 12 (ytm1 homolog). [swissprot;acc:q9gzl7]	251.299	234.729	1.07059
	Subtracted	EXOSC2	exosome complex exonuclease rrp4 (ec 3.1.13.-) (ribosomal rna processing protein 4). [swissprot;acc:q13868]	215.237	230.07	14.833
508	Divided	CPA3	mast cell carboxypeptidase a precursor (ec 3.4.17.1) (mc-cpa) (carboxypeptidase a3). [swissprot;acc:p15088]	177.698	190.24	1.07058
	Subtracted	LSM8	u6 snrna-associated sm-like protein lsm8. [swissprot;acc:o95777]	228.255	213.422	14.833
509	Divided	CPA6	carboxypeptidase b precursor. [refseq;acc:nm_020361]	177.698	190.239	1.07057
	Subtracted	EXOSC3	exosome complex exonuclease rrp40 (ec 3.1.13.-) (ribosomal rna processing protein 40) (p10) (cgi-102). [swissprot;acc:q9nqt5]	215.237	230.07	14.833
510	Divided	CPB2	plasma carboxypeptidase b2 isoform a preproprotein; carboxypeptidase u; thrombin-activatable fibrinolysis inhibitor; carboxypeptidase b-like protein; thrombin-activable fibrinolysis inhibitor. [refseq;acc:nm_001872]	177.699	190.24	1.07057
	Subtracted	EXOSC5	exosome complex exonuclease rrp46 (ec 3.1.13.-) (ribosomal rna processing protein 46) (p12b) (chronic myelogenous leukemia tumor antigen 28). [swissprot;acc:q9nqt4]	215.237	230.07	14.833
511	Divided	NOL1	proliferating-cell nucleolar antigen p120 (proliferation-associated nucleolar protein p120). [swissprot;acc:p46087]	250.053	233.725	1.06986
	Subtracted	SLC35D2	sqv-7-like protein (fragment). [sptrembl;acc:o95454]	214.754	229.565	14.811
512	Divided	BOP1	block of proliferation 1. [swissprot;acc:q14137]	250.794	234.433	1.06979
	Subtracted	DHX15	putative pre-mrna splicing factor rna helicase (deah box protein 15) (atp-dependent rna helicase #46). [swissprot;acc:o43143]	229.803	215.301	14.502
513	Divided	DVL1	segment polarity protein dishevelled homolog dvl-1 (dishevelled-1) (dsh homolog 1). [swissprot;acc:o14640]	218.596	204.344	1.06975
	Subtracted	LSM6	u6 snrna-associated sm-like protein lsm6 (sm protein f). [swissprot;acc:q9y4y8]	227.483	212.994	14.489
514	Divided	DVL2	segment polarity protein dishevelled homolog dvl-2 (dishevelled-2) (dsh homolog 2). [swissprot;acc:o14641]	218.613	204.382	1.06963
	Subtracted	PLRG1	pleiotropic regulator 1 (prl1homolog, arabidopsis); pleiotropic regulator 1 (prl1, arabidopsis homolog). [refseq;acc:nm_002669]	222.893	208.523	14.37
515	Divided	PES1	pescadillo homolog 1. [swissprot;acc:o00541]	251.297	234.941	1.06962
	Subtracted	AKT1	rac-alpha serine/threonine kinase (ec 2.7.1.-) (rac-pk-alpha) (protein kinase b) (pkb) (c-akt). [swissprot;acc:p31749]	248.463	234.095	14.368
516	Divided	LSM8	u6 snrna-associated sm-like protein lsm8. [swissprot;acc:o95777]	228.255	213.422	1.0695
	Subtracted	AKT3	rac-gamma serine/threonine protein kinase (ec 2.7.1.-) (rac-pk-gamma) (protein kinase akt-3) (protein kinase b, gamma) (pkb gamma) (stk-2). [swissprot;acc:q9y243]	248.463	234.095	14.368
517	Divided	MTX2	metaxin 2. [swissprot;acc:o75431]	219.537	234.793	1.06949
	Subtracted	AKT2	rac-beta serine/threonine protein kinase (ec 2.7.1.-) (rac-pk-beta) (protein kinase akt-2) (protein kinase b, beta) (pkb beta). [swissprot;acc:p31751]	248.463	234.095	14.368
518	Divided	GNL3	nucleostemin; putative nucleotide binding protein, estradiol-induced. [refseq;acc:nm_014366]	250.858	234.563	1.06947
	Subtracted	DVL1	segment polarity protein dishevelled homolog dvl-1 (dishevelled-1) (dsh homolog 1). [swissprot;acc:o14640]	218.596	204.344	14.252
519	Divided	DVL3	segment polarity protein dishevelled homolog dvl-3 (dishevelled-3) (dsh homolog 3). [swissprot;acc:q92997]	218.702	204.582	1.06902
	Subtracted	DVL2	segment polarity protein dishevelled homolog dvl-2 (dishevelled-2) (dsh homolog 2). [swissprot;acc:o14641]	218.613	204.382	14.231
520	Divided	SLC35D2	sqv-7-like protein (fragment). [sptrembl;acc:o95454]	214.754	229.565	1.06897
	Subtracted	PRPF19	nuclear matrix protein nmp200 related to splicing factor prp19. [refseq;acc:nm_014502]	223.356	209.149	14.207
521	Divided	EXOSC4	exosome complex exonuclease rrp41 (ec 3.1.13.-) (ribosomal rna processing protein 41) (p12a). [swissprot;acc:q9npd3]	215.237	230.07	1.06891
	Subtracted	DVL3	segment polarity protein dishevelled homolog dvl-3 (dishevelled-3) (dsh homolog 3). [swissprot;acc:q92997]	218.702	204.582	14.12
522	Divided	PLRG1	pleiotropic regulator 1 (prl1homolog, arabidopsis); pleiotropic regulator 1 (prl1, arabidopsis homolog). [refseq;acc:nm_002669]	222.893	208.523	1.06891
	Subtracted	SFRS11	splicing factor arginine/serine-rich 11 (arginine-rich 54 kda nuclear protein) (p54). [swissprot;acc:q05519]	229.709	215.631	14.078
523	Divided	EXOSC2	exosome complex exonuclease rrp4 (ec 3.1.13.-) (ribosomal rna processing protein 4). [swissprot;acc:q13868]	215.237	230.07	1.06891
	Subtracted	HIST1H2BL	histone h2b.c (h2b/c). [swissprot;acc:q99880]	247.47	233.441	14.029
524	Divided	EXOSC3	exosome complex exonuclease rrp40 (ec 3.1.13.-) (ribosomal rna processing protein 40) (p10) (cgi-102). [swissprot;acc:q9nqt5]	215.237	230.07	1.06891
	Subtracted	HIST2H2BA	histone h2b.q (h2b/q) (h2b-gl105). [swissprot;acc:q16778]	247.47	233.441	14.029
525	Divided	EXOSC5	exosome complex exonuclease rrp46 (ec 3.1.13.-) (ribosomal rna processing protein 46) (p12b) (chronic myelogenous leukemia tumor antigen 28). [swissprot;acc:q9nqt4]	215.237	230.07	1.06891
	Subtracted	no value	histone h3.1 (h3/a) (h3/c) (h3/d) (h3/f) (h3/h) (h3/i) (h3/j) (h3/k) (h3/l). [swissprot;acc:p16106]	247.47	233.441	14.029
526	Divided	RRP1	nnp-1 protein (novel nuclear protein 1) (nucleolar protein nop52) (nop52) (d21s2056e). [swissprot;acc:p56182]	250.538	234.401	1.06884
	Subtracted	no value	histone h2b. [refseq;acc:nm_175055]	247.47	233.441	14.029
527	Divided	DDX31	dead (asp-glu-ala-asp) box polypeptide 31 isoform 1; dead/dexh helicase ddx31. [refseq;acc:nm_022779]	248.56	232.579	1.06871
	Subtracted	no value	histone h2b.s (h2b/s). [swissprot;acc:p57053]	247.47	233.441	14.029
528	Divided	YME1L1	yme1-like 1 isoform 3; atp-dependent metalloprotease ftsh1 homolog. [refseq;acc:nm_014263]	222.146	237.393	1.06864
	Subtracted	no value	histone h2b.d (h2b/d). [swissprot;acc:q99877]	247.47	233.441	14.029
529	Divided	DDX18	atp-dependent rna helicase ddx18 (dead-box protein 18) (myc-regulated dead-box protein) (mrdb). [swissprot;acc:q9nvp1]	251.653	235.506	1.06856
	Subtracted	HIST3H3	histone h3.4 (h3t) (h3/t) (h3/g). [swissprot;acc:q16695]	247.47	233.441	14.029
530	Divided	LSM6	u6 snrna-associated sm-like protein lsm6 (sm protein f). [swissprot;acc:q9y4y8]	227.483	212.994	1.06803
	Subtracted	HIST1H2BA	testis-specific histone h2b; h2b histone family, member u, (testis-specific). [refseq;acc:nm_170610]	247.47	233.441	14.029
531	Divided	PRPF19	nuclear matrix protein nmp200 related to splicing factor prp19. [refseq;acc:nm_014502]	223.356	209.149	1.06793

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.