MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Gene	description	Network Comparison Type	Rank	Value Type	Hugo	Interaction Map	Filtered	red	network_comparison	green

Results: HTML CSV LaTeX

Showing element 1008 to 1057 of 25824 in total

Interaction Map  : High confidence
Filtered  : 1

description	Network Comparison Type	Rank	Value Type	Hugo	red	network_comparison	green
60s ribosomal protein l14 (cag-isl 7). [swissprot;acc:p50914]	Subtracted	2504	Squared	no value	12429.9	1132.7	13562.6
60s ribosomal protein l15. [swissprot;acc:p39030]	Divided	604	Ranked	RPL15	217.862	1.0602	230.978
		1089	Squared		17766.4	1.14552	20351.7
		2238	Rooted		59.1718	1.02112	57.9477
		2532	Measured		4888.72	1.02401	5006.1
	Subtracted	577	Ranked		217.862	13.116	230.978
		1546	Squared		17766.4	2585.3	20351.7
		2312	Rooted		59.1718	1.2241	57.9477
		2530	Measured		4888.72	117.38	5006.1
60s ribosomal protein l17 (l23). [swissprot;acc:p18621]	Divided	281	Ranked	no value	241.808	1.10557	267.335
		343	Rooted		50.3169	1.10749	45.4333
		1894	Measured		3598.08	1.06308	3384.59
		2212	Squared		12360.4	1.08331	13390.2
	Subtracted	200	Ranked		241.808	25.527	267.335
		590	Rooted		50.3169	4.8836	45.4333
		2362	Measured		3598.08	213.49	3384.59
		2538	Squared		12360.4	1029.8	13390.2
60s ribosomal protein l18. [swissprot;acc:q07020]	Divided	485	Ranked	RPL18	237.109	1.07405	254.667
		969	Rooted		52.9804	1.0576	50.0947
		1618	Squared		15399.5	1.10834	17067.9
		2694	Measured		4113.79	1.00446	4095.53
	Subtracted	411	Ranked		237.109	17.558	254.667
		1188	Rooted		52.9804	2.8857	50.0947
		2244	Squared		15399.5	1668.4	17067.9
		2734	Measured		4113.79	18.26	4095.53
60s ribosomal protein l18a. [swissprot;acc:q02543]	Divided	770	Rooted	no value	55.6817	1.06639	59.3786
		806	Measured		4708.61	1.11003	5226.71
		860	Ranked		234.025	1.04031	224.958
		1128	Squared		18854.4	1.14246	21540.4
	Subtracted	819	Ranked		234.025	9.067	224.958
		906	Rooted		55.6817	3.6969	59.3786
		1098	Measured		4708.61	518.1	5226.71
		1477	Squared		18854.4	2686	21540.4
60s ribosomal protein l19. [swissprot;acc:p14118]	Divided	319	Ranked	RPL19	240.73	1.09969	264.729
		435	Rooted		50.832	1.09769	46.3081
		2054	Squared		12769	1.09001	13918.3
		2136	Measured		3687.49	1.05381	3499.2
	Subtracted	245	Ranked		240.73	23.999	264.729
		690	Rooted		50.832	4.5239	46.3081
		2401	Measured		3687.49	188.29	3499.2
		2491	Squared		12769	1149.3	13918.3
60s ribosomal protein l21. [swissprot;acc:p46778]	Divided	1051	Rooted	no value	60.1366	1.05133	63.2237
		1054	Ranked		223.958	1.03082	217.263
		1510	Measured		5546.11	1.07426	5957.99
		2453	Squared		25226.2	1.05997	26738.9
	Subtracted	1019	Ranked		223.958	6.695	217.263
		1111	Rooted		60.1366	3.0871	63.2237
		1663	Measured		5546.11	411.88	5957.99
		2308	Squared		25226.2	1512.7	26738.9
60s ribosomal protein l22 (epstein-barr virus small rna associated protein) (eber associated protein) (eap) (heparin binding protein hbp15). [swissprot;acc:p35268]	Divided	2205	Ranked		199.129	1.00645	200.413

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.