MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	Hugo	description	Value Type	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 1008 to 1057 of 16578 in total

Value Type  : Ranked
Filtered  : 1

Rank	Hugo	description	Network Comparison Type	Interaction Map	red	green	network_comparison
252	SNRPB2	u2 small nuclear ribonucleoprotein b". [swissprot;acc:p08579]	Subtracted	Low confidence	202.654	193.53	9.124
253	CDC73	parafibromin. [refseq;acc:nm_024529]			214.015	204.916	9.099
	MXD1	mad protein (max dimerizer). [swissprot;acc:q05195]	Divided	High confidence	228	204.333	1.11583
	NFYB	nuclear transcription factor y subunit beta (nf-y protein chain b) (nf-yb) (ccaat-binding transcription factor subunit a) (cbf-a) (caat- box dna binding protein subunit b). [swissprot;acc:p25208]	Subtracted		251.679	228.037	23.642
	NOX4	nadph oxidase 4. [refseq;acc:nm_016931]	Divided	Low confidence	210.413	201.035	1.04665
254	ATP2C2	probable calcium-transporting atpase kiaa0703 (ec 3.6.3.8). [swissprot;acc:o75185]	Subtracted		218.785	209.763	9.022
	MXI1	max interacting protein 1 (mxi1 protein). [swissprot;acc:p50539]		High confidence	227.999	204.357	23.642
	NOX3	nadph oxidase 3; nadph oxidase catalytic subunit-like 3. [refseq;acc:nm_015718]	Divided	Low confidence	210.414	201.035	1.04665
	STT3B	source of immunodominant mhc-associated peptides; homolog of yeast stt3 gene. [refseq;acc:nm_178862]		High confidence	200.691	179.88	1.11569
255	MXD4	max-interacting transcriptional repressor mad4 (max-associated protein 4) (max dimerization protein 4). [swissprot;acc:q14582]	Subtracted		227.999	204.366	23.633
	NOX1	nadph oxidase homolog 1 (nox-1) (noh-1) (nadh/nadph mitogenic oxidase subunit p65-mox) (mitogenic oxidase 1) (mox1). [swissprot;acc:q9y5s8]	Divided	Low confidence	210.413	201.035	1.04665
	NUBP2	nucleotide binding protein 2 (nbp 2). [swissprot;acc:q9y5y2]	Subtracted		200.699	191.678	9.021
	STT3A	oligosaccharyl transferase stt3 subunit homolog (b5) (integral membrane protein 1) (tmc). [swissprot;acc:p46977]	Divided	High confidence	200.691	179.88	1.11569
256	MXI1	max interacting protein 1 (mxi1 protein). [swissprot;acc:p50539]			227.999	204.357
	RAB24	max dimerization protein 3; likely ortholog of mouse max dimerization protein 3. [refseq;acc:nm_031300]	Subtracted			204.37	23.629
	SOAT2	sterol o-acyltransferase 2 (ec 2.3.1.26) (cholesterol acyltransferase 2) (acyl coenzyme a:cholesterol acyltransferase 2) (acat-2). [swissprot;acc:o75908]		Low confidence	208.469	199.455	9.014
	STT3A	oligosaccharyl transferase stt3 subunit homolog (b5) (integral membrane protein 1) (tmc). [swissprot;acc:p46977]	Divided		199.376	190.521	1.04648
257	CMPK	ump-cmp kinase (ec 2.7.4.14) (cytidylate kinase) (deoxycytidylate kinase) (cytidine monophosphate kinase). [swissprot;acc:p30085]	Subtracted	High confidence	242.14	265.697	23.557
	DDOST	dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kda subunit precursor (ec 2.4.1.119) (oligosaccharyl transferase 48 kda subunit) (ddost 48 kda subunit). [swissprot;acc:p39656]	Divided		200.691	179.88	1.11569
	JAG2	jagged 2 precursor (jagged2) (hj2). [swissprot;acc:q9y219]	Subtracted	Low confidence	218.715	209.71	9.005
	TPM3	tropomyosin alpha 3 chain (tropomyosin 3) (tropomyosin gamma). [swissprot;acc:p06753]	Divided		201.316	192.404	1.04632
258	AK3	gtp:amp phosphotransferase mitochondrial (ec 2.7.4.10) (ak3) (adenylate kinase 3 alpha like 1). [swissprot;acc:q9uij7]	Subtracted	High confidence	242.14	265.697	23.557
	JAG1	jagged 1 precursor (jagged1) (hj1). [swissprot;acc:p78504]		Low confidence	218.714	209.709	9.005
	MXD4	max-interacting transcriptional repressor mad4 (max-associated protein 4) (max dimerization protein 4). [swissprot;acc:q14582]	Divided	High confidence	227.999	204.366	1.11564
	TPM1	tropomyosin 1 alpha chain (alpha-tropomyosin). [swissprot;acc:p09493]		Low confidence	201.304	192.427	1.04613
259	no value	adenylate kinase isoenzyme 4, mitochondrial (ec 2.7.4.3) (atp-amp transphosphorylase). [swissprot;acc:p27144]	Subtracted	High confidence	242.14	265.696	23.556
	MEF2C	myocyte-specific enhancer factor 2c. [swissprot;acc:q06413]		Low confidence	218.714	209.709	9.005
	PDSS1	trans-prenyltransferase; polyprenyl pyrophosphate synthetase. [refseq;acc:nm_014317]	Divided		211.794	202.482	1.04599
	RAB24	max dimerization protein 3; likely ortholog of mouse max dimerization protein 3. [refseq;acc:nm_031300]		High confidence	227.999	204.37	1.11562
260	ANKRD7	ankyrin repeat domain protein 7 (testis-specific protein tsa806). [swissprot;acc:q92527]		Low confidence	216.855	207.34	1.04589
	HS3ST6	c439a6.1 (novel protein similar to heparan sulfate (glucosamine) 3-o- sulfotransferases) (fragment). [sptrembl;acc:q96qi5]		High confidence	219.421	196.978	1.11394
	MED22	surfeit locus protein 5. [swissprot;acc:q15528]	Subtracted		242.14	265.696	23.556
	MEF2A	myocyte-specific enhancer factor 2a (serum response factor-like protein 1). [swissprot;acc:q02078]		Low confidence	218.715	209.71	9.005
261	ANKRD19	ba526d8.2 (novel protein similar to kiaa1074). [sptrembl;acc:q9h560]	Divided		216.845	207.333	1.04588
	HS3ST3A1	heparan sulfate d-glucosaminyl 3-o-sulfotransferase 3a1; heparin-glucosamine 3-o-sulfotransferase. [refseq;acc:nm_006042]		High confidence	219.421	196.978	1.11394
	MEF2D	myocyte-specific enhancer factor 2d. [swissprot;acc:q14814]	Subtracted	Low confidence	218.713	209.709	9.004
	SCAPER	zinc finger protein 291. [swissprot;acc:q9by12]		High confidence	242.14	265.696	23.556
262	ANKRD30A	breast cancer antigen ny-br-1. [refseq;acc:nm_052997]	Divided	Low confidence	216.842	207.332	1.04587
	HS3ST3B1	heparan sulfate d-glucosaminyl 3-o-sulfotransferase 3b1. [refseq;acc:nm_006041]		High confidence	219.421	196.978	1.11394
	PEX1	peroxisome biogenesis factor 1 (peroxin-1) (peroxisome biogenesis disorder protein 1). [swissprot;acc:o43933]	Subtracted		242.14	265.696	23.556
	RNF10	ring finger protein 10. [refseq;acc:nm_014868]		Low confidence	208.437	199.44	8.997
263	no value	sodium/hydrogen exchanger 6 (na(+)/h(+) exchanger 6) (nhe-6). [swissprot;acc:q92581]	Divided		216.546	207.063	1.0458
	HS3ST2	heparan sulfate d-glucosaminyl 3-o-sulfotransferase 2; heparin-glucosamine 3-o-sulfotransferase. [refseq;acc:nm_006043]		High confidence	219.421	196.978	1.11394
	SOAT1	sterol o-acyltransferase 1 (ec 2.3.1.26) (cholesterol acyltransferase 1) (acyl coenzyme a:cholesterol acyltransferase 1) (acat-1). [swissprot;acc:p35610]	Subtracted	Low confidence	208.436	199.44	8.996
	TXNDC9	protein 1-4 (atp binding protein associated with cell differentiation). [swissprot;acc:o14530]		High confidence	242.14	265.696	23.556
264	no value	60s ribosomal protein l10a (csa-19). [swissprot;acc:p53025]			243.24	266.796
	ATP2C1	calcium-transporting atpase type 2c, member 1 (ec 3.6.3.8) (atpase 2c1) (atp-dependent ca(2+) pump pmr1) (hussy-28). [swissprot;acc:p98194]		Low confidence	218.661	209.669	8.992
	DCPS	mrna decapping enzyme; histidine triad protein member 5; heat shock-like protein 1. [refseq;acc:nm_014026]	Divided	High confidence	219.421	196.978	1.11394
	LEO1	senescence downregulated leo1-like. [refseq;acc:nm_138792]		Low confidence	216.546	207.063	1.0458
265	no value	60s ribosomal protein l9. [swissprot;acc:p32969]	Subtracted	High confidence	240.243	263.798	23.555

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.