MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	description	Gene	Hugo	Value Type	Network Comparison Type	Interaction Map	Filtered	red	network_comparison	green

Results: HTML CSV LaTeX

Showing element 1008 to 1057 of 6456 in total

Value Type  : Ranked
Interaction Map  : High confidence
Filtered  : 1

Rank	description	Hugo	Network Comparison Type	red	network_comparison	green
504	oligophrenin 1. [swissprot;acc:o60890]	OPHN1	Divided	238.704	1.07112	255.68
505	ad24 protein. [refseq;acc:nm_022451]	NOC3L		251.334	1.071	234.672
	zinc finger protein t86. [swissprot;acc:o00488]	ZNF593	Subtracted	246.805	15.009	231.796
506	exosome complex exonuclease rrp41 (ec 3.1.13.-) (ribosomal rna processing protein 41) (p12a). [swissprot;acc:q9npd3]	EXOSC4		215.237	14.833	230.07
	inhibitor of growth family, member 1; inhibitor of growth 1. [refseq;acc:nm_005537]	ING1	Divided	224.535	1.071	240.476
507	exosome complex exonuclease rrp4 (ec 3.1.13.-) (ribosomal rna processing protein 4). [swissprot;acc:q13868]	EXOSC2	Subtracted	215.237	14.833	230.07
	wd-repeat protein 12 (ytm1 homolog). [swissprot;acc:q9gzl7]	WDR12	Divided	251.299	1.07059	234.729
508	mast cell carboxypeptidase a precursor (ec 3.4.17.1) (mc-cpa) (carboxypeptidase a3). [swissprot;acc:p15088]	CPA3		177.698	1.07058	190.24
	u6 snrna-associated sm-like protein lsm8. [swissprot;acc:o95777]	LSM8	Subtracted	228.255	14.833	213.422
509	carboxypeptidase b precursor. [refseq;acc:nm_020361]	CPA6	Divided	177.698	1.07057	190.239
	exosome complex exonuclease rrp40 (ec 3.1.13.-) (ribosomal rna processing protein 40) (p10) (cgi-102). [swissprot;acc:q9nqt5]	EXOSC3	Subtracted	215.237	14.833	230.07
510	exosome complex exonuclease rrp46 (ec 3.1.13.-) (ribosomal rna processing protein 46) (p12b) (chronic myelogenous leukemia tumor antigen 28). [swissprot;acc:q9nqt4]	EXOSC5
	plasma carboxypeptidase b2 isoform a preproprotein; carboxypeptidase u; thrombin-activatable fibrinolysis inhibitor; carboxypeptidase b-like protein; thrombin-activable fibrinolysis inhibitor. [refseq;acc:nm_001872]	CPB2	Divided	177.699	1.07057	190.24
511	proliferating-cell nucleolar antigen p120 (proliferation-associated nucleolar protein p120). [swissprot;acc:p46087]	NOL1		250.053	1.06986	233.725
	sqv-7-like protein (fragment). [sptrembl;acc:o95454]	SLC35D2	Subtracted	214.754	14.811	229.565
512	block of proliferation 1. [swissprot;acc:q14137]	BOP1	Divided	250.794	1.06979	234.433
	putative pre-mrna splicing factor rna helicase (deah box protein 15) (atp-dependent rna helicase #46). [swissprot;acc:o43143]	DHX15	Subtracted	229.803	14.502	215.301
513	segment polarity protein dishevelled homolog dvl-1 (dishevelled-1) (dsh homolog 1). [swissprot;acc:o14640]	DVL1	Divided	218.596	1.06975	204.344
	u6 snrna-associated sm-like protein lsm6 (sm protein f). [swissprot;acc:q9y4y8]	LSM6	Subtracted	227.483	14.489	212.994
514	pleiotropic regulator 1 (prl1homolog, arabidopsis); pleiotropic regulator 1 (prl1, arabidopsis homolog). [refseq;acc:nm_002669]	PLRG1		222.893	14.37	208.523
	segment polarity protein dishevelled homolog dvl-2 (dishevelled-2) (dsh homolog 2). [swissprot;acc:o14641]	DVL2	Divided	218.613	1.06963	204.382
515	pescadillo homolog 1. [swissprot;acc:o00541]	PES1		251.297	1.06962	234.941
	rac-alpha serine/threonine kinase (ec 2.7.1.-) (rac-pk-alpha) (protein kinase b) (pkb) (c-akt). [swissprot;acc:p31749]	AKT1	Subtracted	248.463	14.368	234.095
516	rac-gamma serine/threonine protein kinase (ec 2.7.1.-) (rac-pk-gamma) (protein kinase akt-3) (protein kinase b, gamma) (pkb gamma) (stk-2). [swissprot;acc:q9y243]	AKT3
	u6 snrna-associated sm-like protein lsm8. [swissprot;acc:o95777]	LSM8	Divided	228.255	1.0695	213.422
517	metaxin 2. [swissprot;acc:o75431]	MTX2		219.537	1.06949	234.793
	rac-beta serine/threonine protein kinase (ec 2.7.1.-) (rac-pk-beta) (protein kinase akt-2) (protein kinase b, beta) (pkb beta). [swissprot;acc:p31751]	AKT2	Subtracted	248.463	14.368	234.095
518	nucleostemin; putative nucleotide binding protein, estradiol-induced. [refseq;acc:nm_014366]	GNL3	Divided	250.858	1.06947	234.563
	segment polarity protein dishevelled homolog dvl-1 (dishevelled-1) (dsh homolog 1). [swissprot;acc:o14640]	DVL1	Subtracted	218.596	14.252	204.344
519	segment polarity protein dishevelled homolog dvl-2 (dishevelled-2) (dsh homolog 2). [swissprot;acc:o14641]	DVL2		218.613	14.231	204.382
	segment polarity protein dishevelled homolog dvl-3 (dishevelled-3) (dsh homolog 3). [swissprot;acc:q92997]	DVL3	Divided	218.702	1.06902	204.582
520	nuclear matrix protein nmp200 related to splicing factor prp19. [refseq;acc:nm_014502]	PRPF19	Subtracted	223.356	14.207	209.149
	sqv-7-like protein (fragment). [sptrembl;acc:o95454]	SLC35D2	Divided	214.754	1.06897	229.565
521	exosome complex exonuclease rrp41 (ec 3.1.13.-) (ribosomal rna processing protein 41) (p12a). [swissprot;acc:q9npd3]	EXOSC4		215.237	1.06891	230.07
	segment polarity protein dishevelled homolog dvl-3 (dishevelled-3) (dsh homolog 3). [swissprot;acc:q92997]	DVL3	Subtracted	218.702	14.12	204.582
522	pleiotropic regulator 1 (prl1homolog, arabidopsis); pleiotropic regulator 1 (prl1, arabidopsis homolog). [refseq;acc:nm_002669]	PLRG1	Divided	222.893	1.06891	208.523
	splicing factor arginine/serine-rich 11 (arginine-rich 54 kda nuclear protein) (p54). [swissprot;acc:q05519]	SFRS11	Subtracted	229.709	14.078	215.631
523	exosome complex exonuclease rrp4 (ec 3.1.13.-) (ribosomal rna processing protein 4). [swissprot;acc:q13868]	EXOSC2	Divided	215.237	1.06891	230.07
	histone h2b.c (h2b/c). [swissprot;acc:q99880]	HIST1H2BL	Subtracted	247.47	14.029	233.441
524	exosome complex exonuclease rrp40 (ec 3.1.13.-) (ribosomal rna processing protein 40) (p10) (cgi-102). [swissprot;acc:q9nqt5]	EXOSC3	Divided	215.237	1.06891	230.07
	histone h2b.q (h2b/q) (h2b-gl105). [swissprot;acc:q16778]	HIST2H2BA	Subtracted	247.47	14.029	233.441
525	exosome complex exonuclease rrp46 (ec 3.1.13.-) (ribosomal rna processing protein 46) (p12b) (chronic myelogenous leukemia tumor antigen 28). [swissprot;acc:q9nqt4]	EXOSC5	Divided	215.237	1.06891	230.07
	histone h3.1 (h3/a) (h3/c) (h3/d) (h3/f) (h3/h) (h3/i) (h3/j) (h3/k) (h3/l). [swissprot;acc:p16106]	no value	Subtracted	247.47	14.029	233.441
526	histone h2b. [refseq;acc:nm_175055]
	nnp-1 protein (novel nuclear protein 1) (nucleolar protein nop52) (nop52) (d21s2056e). [swissprot;acc:p56182]	RRP1	Divided	250.538	1.06884	234.401
527	dead (asp-glu-ala-asp) box polypeptide 31 isoform 1; dead/dexh helicase ddx31. [refseq;acc:nm_022779]	DDX31		248.56	1.06871	232.579
	histone h2b.s (h2b/s). [swissprot;acc:p57053]	no value	Subtracted	247.47	14.029	233.441
528	histone h2b.d (h2b/d). [swissprot;acc:q99877]
	yme1-like 1 isoform 3; atp-dependent metalloprotease ftsh1 homolog. [refseq;acc:nm_014263]	YME1L1	Divided	222.146	1.06864	237.393
529	atp-dependent rna helicase ddx18 (dead-box protein 18) (myc-regulated dead-box protein) (mrdb). [swissprot;acc:q9nvp1]	DDX18		251.653	1.06856	235.506

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.