MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	Hugo	description	Value Type	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 1008 to 1057 of 8289 in total

Value Type  : Ranked
Network Comparison Type  : Divided
Filtered  : 1

Rank	Hugo	description	Interaction Map	red	green	network_comparison
504	RNF113A	zinc finger protein 183. [swissprot;acc:o15541]	Low confidence	205.192	198.726	1.03254
505	NOC3L	ad24 protein. [refseq;acc:nm_022451]	High confidence	251.334	234.672	1.071
	PCNA	proliferating cell nuclear antigen (pcna) (cyclin). [swissprot;acc:p12004]	Low confidence	207.84	201.297	1.0325
506	FOXO4	putative fork head domain transcription factor afx1 (forkhead box protein o4). [swissprot;acc:p98177]		205.157	198.715	1.03242
	ING1	inhibitor of growth family, member 1; inhibitor of growth 1. [refseq;acc:nm_005537]	High confidence	224.535	240.476	1.071
507	no value	hemoglobin gamma-a and gamma-g chains. [swissprot;acc:p02096]	Low confidence	205.157	198.715	1.03242
	WDR12	wd-repeat protein 12 (ytm1 homolog). [swissprot;acc:q9gzl7]	High confidence	251.299	234.729	1.07059
508	APP	amyloid beta a4 protein precursor (app) (abpp) (alzheimer's disease amyloid protein) (cerebral vascular amyloid peptide) (cvap) (protease nexin-ii) (pn-ii) (appi) (prea4) [contains: soluble app-alpha (s-app- alpha); soluble app-beta (s-app-beta); c99; beta-amyloid protein 42 (beta-app42); beta-amyloid protein 40 (beta-app40); c83; p3(42); p3(40); gamma-ctf(59) (gamma-secretase c-terminal fragment 59) (amyloid intracellular domain 59) (aid(59)); gamma-ctf(57) (gamma- secretase c-terminal fragment 57) (amyloid intracellular domain 57) (aid(57)); gamma-ctf(50) (gamma-secretase c-terminal fragment 50) (amyloid intracellular domain 50) (aid(50)); c31]. [swissprot;acc:p05067]	Low confidence	205.157	198.715	1.03242
	CPA3	mast cell carboxypeptidase a precursor (ec 3.4.17.1) (mc-cpa) (carboxypeptidase a3). [swissprot;acc:p15088]	High confidence	177.698	190.24	1.07058
509	CPA6	carboxypeptidase b precursor. [refseq;acc:nm_020361]			190.239	1.07057
	TTYH2	tweety homolog 2. [refseq;acc:nm_032646]	Low confidence	205.157	198.715	1.03242
510	CPB2	plasma carboxypeptidase b2 isoform a preproprotein; carboxypeptidase u; thrombin-activatable fibrinolysis inhibitor; carboxypeptidase b-like protein; thrombin-activable fibrinolysis inhibitor. [refseq;acc:nm_001872]	High confidence	177.699	190.24	1.07057
	HBZ	hemoglobin zeta chain (hbaz). [swissprot;acc:p02008]	Low confidence	205.157	198.715	1.03242
511	no value	alpha 2 globin. [refseq;acc:nm_000517]
	NOL1	proliferating-cell nucleolar antigen p120 (proliferation-associated nucleolar protein p120). [swissprot;acc:p46087]	High confidence	250.053	233.725	1.06986
512	APLP1	amyloid-like protein 1 precursor (aplp) (aplp-1) [contains: c30]. [swissprot;acc:p51693]	Low confidence	205.157	198.715	1.03242
	BOP1	block of proliferation 1. [swissprot;acc:q14137]	High confidence	250.794	234.433	1.06979
513	no value	myoglobin. [swissprot;acc:p02144]	Low confidence	205.157	198.715	1.03242
	DVL1	segment polarity protein dishevelled homolog dvl-1 (dishevelled-1) (dsh homolog 1). [swissprot;acc:o14640]	High confidence	218.596	204.344	1.06975
514	DVL2	segment polarity protein dishevelled homolog dvl-2 (dishevelled-2) (dsh homolog 2). [swissprot;acc:o14641]		218.613	204.382	1.06963
	HBQ1	hemoglobin theta-1 chain. [swissprot;acc:p09105]	Low confidence	205.157	198.715	1.03242
515	PES1	pescadillo homolog 1. [swissprot;acc:o00541]	High confidence	251.297	234.941	1.06962
	TTYH1	tweety homolog 1; tweety homolog. [refseq;acc:nm_020659]	Low confidence	205.156	198.715	1.03241
516	CYGB	cytoglobin (histoglobin) (hgb) (stellate cell activation-associated protein). [swissprot;acc:q8wwm9]
	LSM8	u6 snrna-associated sm-like protein lsm8. [swissprot;acc:o95777]	High confidence	228.255	213.422	1.0695
517	FOXO3	forkhead box protein o3a (forkhead in rhabdomyosarcoma-like 1) (af6q21 protein). [swissprot;acc:o43524]	Low confidence	205.156	198.715	1.03241
	MTX2	metaxin 2. [swissprot;acc:o75431]	High confidence	219.537	234.793	1.06949
518	APLP2	amyloid-like protein 2 precursor (amyloid protein homolog) (apph) (cdei-box binding protein) (cdebp). [swissprot;acc:q06481]	Low confidence	205.156	198.715	1.03241
	GNL3	nucleostemin; putative nucleotide binding protein, estradiol-induced. [refseq;acc:nm_014366]	High confidence	250.858	234.563	1.06947
519	DVL3	segment polarity protein dishevelled homolog dvl-3 (dishevelled-3) (dsh homolog 3). [swissprot;acc:q92997]		218.702	204.582	1.06902
	SAMSN1	sam-domain protein samsn-1 (sam domain, sh3 domain and nuclear localisation signals protein 1). [swissprot;acc:q9nsi8]	Low confidence	204.278	210.893	1.03238
520	GYG1	glycogenin-1 (ec 2.4.1.186). [swissprot;acc:p46976]		200.014	193.745	1.03236
	SLC35D2	sqv-7-like protein (fragment). [sptrembl;acc:o95454]	High confidence	214.754	229.565	1.06897
521	EXOSC4	exosome complex exonuclease rrp41 (ec 3.1.13.-) (ribosomal rna processing protein 41) (p12a). [swissprot;acc:q9npd3]		215.237	230.07	1.06891
	SORBS2	arg/abl-interacting protein 2 isoform 2; arg binding protein 2. [refseq;acc:nm_021069]	Low confidence	205.451	199.011	1.03236
522	PLRG1	pleiotropic regulator 1 (prl1homolog, arabidopsis); pleiotropic regulator 1 (prl1, arabidopsis homolog). [refseq;acc:nm_002669]	High confidence	222.893	208.523	1.06891
	SASH1	sam and sh3 domain containing 1. [refseq;acc:nm_015278]	Low confidence	204.276	210.886	1.03236
523	EXOSC2	exosome complex exonuclease rrp4 (ec 3.1.13.-) (ribosomal rna processing protein 4). [swissprot;acc:q13868]	High confidence	215.237	230.07	1.06891
	RNF7	ring finger protein 7; sensitive to apoptosis gene. [refseq;acc:nm_014245]	Low confidence	203.162	196.796	1.03235
524	EXOSC3	exosome complex exonuclease rrp40 (ec 3.1.13.-) (ribosomal rna processing protein 40) (p10) (cgi-102). [swissprot;acc:q9nqt5]	High confidence	215.237	230.07	1.06891
	SLC2A11	solute carrier family 2, facilitated glucose transporter, member 11 (glucose transporter type 11) (glucose transporter type 10). [swissprot;acc:q9byw1]	Low confidence	205.551	199.117	1.03231
525	EXOSC5	exosome complex exonuclease rrp46 (ec 3.1.13.-) (ribosomal rna processing protein 46) (p12b) (chronic myelogenous leukemia tumor antigen 28). [swissprot;acc:q9nqt4]	High confidence	215.237	230.07	1.06891
	SLC2A5	solute carrier family 2, facilitated glucose transporter, member 5 (glucose transporter type 5, small intestine) (fructose transporter). [swissprot;acc:p22732]	Low confidence	205.548	199.116	1.0323
526	RRP1	nnp-1 protein (novel nuclear protein 1) (nucleolar protein nop52) (nop52) (d21s2056e). [swissprot;acc:p56182]	High confidence	250.538	234.401	1.06884
	SLC2A9	solute carrier family 2, facilitated glucose transporter, member 9 (glucose transporter type 9). [swissprot;acc:q9nrm0]	Low confidence	205.549	199.117	1.0323
527	DDX31	dead (asp-glu-ala-asp) box polypeptide 31 isoform 1; dead/dexh helicase ddx31. [refseq;acc:nm_022779]	High confidence	248.56	232.579	1.06871
	EIF5	eukaryotic translation initiation factor 5 (eif-5). [swissprot;acc:p55010]	Low confidence	208.004	201.497	1.03229
528	SLC2A2	solute carrier family 2, facilitated glucose transporter, member 2 (glucose transporter type 2, liver). [swissprot;acc:p11168]		205.543	199.115	1.03228
	YME1L1	yme1-like 1 isoform 3; atp-dependent metalloprotease ftsh1 homolog. [refseq;acc:nm_014263]	High confidence	222.146	237.393	1.06864
529	DDX18	atp-dependent rna helicase ddx18 (dead-box protein 18) (myc-regulated dead-box protein) (mrdb). [swissprot;acc:q9nvp1]		251.653	235.506	1.06856

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.