MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	description	Hugo	Value Type	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

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Showing element 101 to 150 of 66312 in total

Filtered  : 1

Rank	description	Hugo	Value Type	Network Comparison Type	Interaction Map	red	green	network_comparison
7	nuclear dna-binding protein; small unique nuclear receptor corepressor; c1d dna-binding protein. [refseq;acc:nm_006333]	no value	Squared	Subtracted	High confidence	310840	442993	132153
	oxysterol binding protein-related protein 3 (osbp-related protein 3) (orp-3). [swissprot;acc:q9h4l5]	OSBPL3	Ranked	Divided	Low confidence	318	240	1.325
	oxysterol binding protein-related protein 7 (osbp-related protein 7) (orp-7). [swissprot;acc:q9bzf2]	OSBPL7	Measured			736.5	2113.5	2.86965
			Ranked	Subtracted		318	240	78
			Squared	Divided		128.386	1057.25	8.23493
			Rooted			27.1385	45.9728	1.69401
	pantothenate kinase 2, mitochondrial precursor (ec 2.7.1.33) (pantothenic acid kinase 2) (hpank2). [swissprot;acc:q9bz23]	PANK2		Subtracted	High confidence	145.551	168.796	23.245
	protein cgi-126 (protein hspc155). [swissprot;acc:q9y3c8]	UFC1	Ranked			288.754	212.554	76.2
	sphingomyelin phosphodiesterase 2 (ec 3.1.4.12) (neutral sphingomyelinase) (nsmase) (n-smase) (lyso-platelet activating factor- phospholipase c) (lyso-paf-plc). [swissprot;acc:o60906]	SMPD2	Measured	Divided		1153.5	339.5	3.39764
			Squared			314.926	27.2805	11.544
			Rooted			33.9632	18.4255	1.84327
	vitelliform macular dystrophy 2-like protein 1. [refseq;acc:nm_017682]	BEST2	Measured	Subtracted	Low confidence	36360.3	43368.8	7008.5
8	db83 protein. [swissprot;acc:p57088]	TMEM33		Divided	High confidence	1153.5	339.5	3.39764
			Squared			314.926	27.2805	11.544
			Rooted			33.9632	18.4255	1.84327
	deoxyribonuclease ii beta isoform 1 precursor; deoxyribonuclease ii beta; endonuclease dlad. [refseq;acc:nm_021233]	DNASE2B	Measured	Subtracted	Low confidence	33111.4	39358.1	6246.7
			Squared		High confidence	250303	354894	104591
	hbs1-like. [refseq;acc:nm_006620]	HBS1L	Ranked	Divided		215	322	1.49767
	junctophilin 3 (junctophilin type 3) (jp-3). [swissprot;acc:q8wxh2]	JPH3		Subtracted		288	362	74
	mitochondrial solute carrier protein. [refseq;acc:nm_145305]	SLC25A43	Squared		Low confidence	106226	192141	85915
	oxysterol binding protein-related protein 6 (osbp-related protein 6) (orp-6). [swissprot;acc:q9bzf3]	OSBPL6	Rooted			27.1385	45.9728	18.8343
	oxysterol binding protein-related protein 7 (osbp-related protein 7) (orp-7). [swissprot;acc:q9bzf2]	OSBPL7	Ranked	Divided		318	240	1.325
	pantothenate kinase 1 (ec 2.7.1.33) (pantothenic acid kinase 1) (hpank1) (hpank). [swissprot;acc:q8te04]	PANK1	Measured	Subtracted	High confidence	21185	28492	7307
	pantothenate kinase 3 (ec 2.7.1.33) (pantothenic acid kinase 3) (hpank3). [swissprot;acc:q9h999]	PANK3	Rooted			145.551	168.796	23.245
	phosphatidylinositol-glycan biosynthesis, class f protein (pig-f). [swissprot;acc:q07326]	PIGF	Measured	Divided	Low confidence	3278	5058.5	1.54317
			Squared			2543.26	6056.43	2.38136
	thyroid receptor interacting protein 8 (trip-8) (fragment). [swissprot;acc:q15652]	JMJD1C	Ranked	Subtracted		305.472	247.246	58.226
			Rooted	Divided		31.8641	47.6922	1.49674
9	28s ribosomal protein s17, mitochondrial precursor (mrp-s17) (hspc011). [swissprot;acc:q9y2r5]	MRPS17	Ranked			58	44	1.31818
	gbp protein isoform a. [refseq;acc:nm_017870]	TMEM132A		Subtracted		305.399	247.213	58.186
			Rooted	Divided		31.8923	47.7107	1.49599
	junctophilin 2 (junctophilin type 2) (jp-2). [swissprot;acc:q9br39]	JPH2	Ranked	Subtracted	High confidence	288	362	74
	mitochondrial solute carrier protein. [refseq;acc:nm_145305]	SLC25A43	Rooted			145.551	168.796	23.245
	n33 protein. [swissprot;acc:q13454]	TUSC3	Measured	Divided	Low confidence	3278	5058.5	1.54317
			Squared			2543.26	6056.43	2.38136
	oxysterol binding protein-related protein 3 (osbp-related protein 3) (orp-3). [swissprot;acc:q9h4l5]	OSBPL3	Rooted	Subtracted		27.1385	45.9728	18.8343
	pantothenate kinase 2, mitochondrial precursor (ec 2.7.1.33) (pantothenic acid kinase 2) (hpank2). [swissprot;acc:q9bz23]	PANK2	Measured		High confidence	21185	28492	7307
	protein phosphatase 1, regulatory subunit 7; sds22. [refseq;acc:nm_002712]	PPP1R7	Squared			256169	162517	93652
	sperm associated antigen 7. [refseq;acc:nm_004890]	SPAG7	Measured		Low confidence	23318	19280.8	4037.2
			Squared			209554	136572	72982
	tob2 protein (transducer of erbb-2 2). [swissprot;acc:q14106]	TOB2	Measured	Divided	High confidence	398.5	1281.5	3.21581
			Squared			37.5863	388.696	10.3414
			Rooted			19.9625	35.798	1.79326
	xpa binding protein 1; mbd2 interactor protein; putative atp(gtp)-binding protein. [refseq;acc:nm_007266]	XAB1	Ranked			212	309	1.45755
10	implantation-associated protein. [refseq;acc:nm_032121]	no value	Measured		Low confidence	3278	5058.5	1.54317
			Squared			2543.26	6056.43	2.38136
	jumonji domain containing 1; zinc finger protein; testis-specific protein a. [refseq;acc:nm_018433]	JMJD1A	Ranked	Subtracted		305.303	247.169	58.134
			Rooted	Divided		31.9296	47.7352	1.49501
	melanoma antigen, family d, 4 isoform 1; mage1 protein; mage-e1 protein; maged4 protein. [refseq;acc:nm_030801]	MAGED4	Squared	Subtracted	High confidence	219048	129762	89286
	mitochondrial solute carrier protein. [refseq;acc:nm_145305]	SLC25A43	Ranked	Divided	Low confidence	58	44	1.31818

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.