MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

Navigation/Query Panel:
Click on the attribute name to hide/unhide it. The green arrows can be used to shift columns left/right. Exact word match is written as =..., regular expressions can be matched with ~.... To select all values larger or equal than use >.... This would be <... for values smaller or equal than. To select all values within a specific range use [...,...].

description	Gene	Network Comparison Type	Rank	Value Type	Hugo	Interaction Map	Filtered	red	network_comparison	green

Results: HTML CSV LaTeX

Showing element 101 to 150 of 25824 in total

Interaction Map  : High confidence
Filtered  : 1

description	Network Comparison Type	Rank	Value Type	Hugo	red	network_comparison	green
15 kda selenoprotein precursor. [swissprot;acc:o60613]	Subtracted	590	Squared	no value	29772.1	4684.4	34456.5
		865	Measured		6344.41	588.95	6933.36
		1304	Rooted		64.5959	2.6665	67.2624
		1920	Ranked		214.522	2.09	212.432
15-hydroxyprostaglandin dehydrogenase [nad(+)] (ec 1.1.1.141) (pgdh). [swissprot;acc:p15428]	Divided	2855	Measured	HPGD	0.00001	1	0.00001
			Ranked
			Squared
			Rooted
	Subtracted		Measured		0	0	0
			Ranked
			Squared
			Rooted
17 beta-hydroxysteroid dehydrogenase. [sptrembl;acc:q13034]	Divided	1051	Ranked	no value	211.449	1.03097	217.998
		2377	Squared		25809.5	1.06837	27574.1
		2521	Measured		5964.17	1.02511	6113.96
		2642	Rooted		63.9773	1.00617	63.5847
	Subtracted	1029	Ranked		211.449	6.549	217.998
		2200	Squared		25809.5	1764.6	27574.1
		2496	Measured		5964.17	149.79	6113.96
		2633	Rooted		63.9773	0.3926	63.5847
2-hydroxyphytanoyl-coa lyase (ec 4.1.-.-) (2-hpcl) (hspc279). [swissprot;acc:q9uj83]	Divided	1393	Measured	HACL1	5743.36	1.07824	6192.72
		1463	Rooted		60.3015	1.03867	62.6331
		1593	Squared		29261.2	1.10979	32473.8
		2007	Ranked		225.019	1.00919	222.969
	Subtracted	1128	Squared		29261.2	3212.6	32473.8
		1426	Measured		5743.36	449.36	6192.72
		1527	Rooted		60.3015	2.3316	62.6331
		1954	Ranked		225.019	2.05	222.969
2-oxoglutarate dehydrogenase e1 component, mitochondrial precursor (ec 1.2.4.2) (alpha-ketoglutarate dehydrogenase). [swissprot;acc:q02218]	Divided	1160		OGDH	208.55	1.02633	214.041
		2426	Squared		27135.1	1.0631	28847.4
		2506	Measured		6200.39	1.0261	6362.25
		2700	Rooted		65.3323	1.00318	65.1252
	Subtracted	1164	Ranked		208.55	5.491	214.041
		2227	Squared		27135.1	1712.3	28847.4
		2455	Measured		6200.39	161.86	6362.25
		2686	Rooted		65.3323	0.2071	65.1252
2-oxoisovalerate dehydrogenase alpha subunit, mitochondrial precursor (ec 1.2.4.4) (branched-chain alpha-keto acid dehydrogenase e1 component alpha chain) (bckdh e1-alpha). [swissprot;acc:p12694]	Divided	1484	Ranked	TMEM91	198.927	1.0191	202.726
		1699	Squared		28693.8	1.10476	31699.9
		2451	Measured		6737.15	1.03268	6957.34
		2716	Rooted		69.1013	1.00141	69.1987
	Subtracted	1230	Squared		28693.8	3006.1	31699.9
		1515	Ranked		198.927	3.799	202.726
		2344	Measured		6737.15	220.19	6957.34
		2715	Rooted		69.1013	0.0974	69.1987
2-oxoisovalerate dehydrogenase beta subunit, mitochondrial precursor (ec 1.2.4.4) (branched-chain alpha-keto acid dehydrogenase e1 component beta chain) (bckdh e1-beta). [swissprot;acc:p21953]	Divided	1389	Ranked	BCKDHB	218.47	1.02148	213.875
		1579	Rooted		61.9705	1.03588	64.1938
		2288	Measured		5783.76	1.04585	6048.94
		2488	Squared		25184.8	1.05791	26643.2
	Subtracted	1336	Ranked		218.47	4.595	213.875
		1619	Rooted		61.9705	2.2233	64.1938

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.