MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	Hugo	description	Value Type	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 101 to 150 of 25824 in total

Interaction Map  : High confidence
Filtered  : 1

Rank	Hugo	description	Value Type	Network Comparison Type	red	green	network_comparison
13	GNG12	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-12 subunit. [swissprot;acc:q9ubi6]	Ranked	Subtracted	266.856	336.233	69.377
	MAGEA11	melanoma-associated antigen 11 (mage-11 antigen). [swissprot;acc:p43364]	Squared		219048	129762	89286
	MYO5B	myosin vb (myosin 5b) (fragment). [swissprot;acc:q9ulv0]	Measured		21591.5	27904.5	6313
	UFC1	protein cgi-126 (protein hspc155). [swissprot;acc:q9y3c8]	Ranked	Divided	288.754	212.554	1.3585
14	ATG4A	cysteine endopeptidase aut-like 2 isoform a; autophagy-related cysteine endopeptidase 2; autophagin 2. [refseq;acc:nm_052936]			56.6768	75.3531	1.32952
	GNG4	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-4 subunit. [swissprot;acc:p50150]		Subtracted	266.863	336.191	69.328
	MAGEA2B	melanoma-associated antigen 2 (mage-2 antigen). [swissprot;acc:p43356]	Squared		219048	129762	89286
	MYO5C	myosin vc (myosin 5c). [swissprot;acc:q9nqx4]	Measured		21591.5	27904.5	6313
	RASAL2	ras gtpase-activating protein ngap (ras protein activator like 1). [swissprot;acc:q9ujf2]		Divided	398.5	1281.5	3.21581
			Squared		37.5863	388.696	10.3414
			Rooted		19.9625	35.798	1.79326
	SPATA6	spermatogenesis associated 6. [refseq;acc:nm_019073]		Subtracted	80.4705	101.526	21.0555
15	no value	hepatocellular carcinoma-associated protein hca1. [refseq;acc:nm_020932]	Squared		219048	129762	89286
		myosin va (myosin 5a) (dilute myosin heavy chain, non-muscle) (myosin heavy chain 12) (myoxin). [swissprot;acc:q9y4i1]	Measured		21591.5	27904.5	6313
	AMPD2	amp deaminase 2 (ec 3.5.4.6) (amp deaminase isoform l). [swissprot;acc:q01433]	Rooted		80.4705	101.526	21.0555
	GNG3	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-3 subunit. [swissprot;acc:p29798]	Ranked		266.863	336.19	69.327
	MAP1LC3B	microtubule-associated proteins 1a/1b light chain 3b (map1a/map1b lc3 b) (map1a/1b light chain 3 b). [swissprot;acc:q9gzq8]		Divided	56.7244	75.3948	1.32914
	TMEM132A	gbp protein isoform a. [refseq;acc:nm_017870]	Rooted		23.9771	42.4773	1.77158
	XAB1	xpa binding protein 1; mbd2 interactor protein; putative atp(gtp)-binding protein. [refseq;acc:nm_007266]	Measured		2671	871	3.06659
			Squared		1688.58	179.56	9.40399
16	no value	mannosyl-oligosaccharide 1,2-alpha-mannosidase ib (ec 3.2.1.113) (processing alpha-1,2-mannosidase ib) (alpha-1,2-mannosidase ib) (mannosidase alpha class 1a member 2). [swissprot;acc:o60476]	Rooted	Subtracted	203.673	182.638	21.035
	ATG4A	cysteine endopeptidase aut-like 2 isoform a; autophagy-related cysteine endopeptidase 2; autophagin 2. [refseq;acc:nm_052936]	Measured		24260.3	18172.1	6088.2
	ATPBD1C	protein x 0004. [refseq;acc:nm_016301]		Divided	2671	871	3.06659
			Squared		1688.58	179.56	9.40399
	GNG8	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-8 subunit (gamma-9). [swissprot;acc:q9uk08]	Ranked	Subtracted	266.864	336.184	69.32
	MAGEA6	melanoma-associated antigen 6 (mage-6 antigen) (mage3b). [swissprot;acc:p43360]	Squared		219048	129762	89286
	MAP1LC3A	microtubule-associated proteins 1a/1b light chain 3a (map1a/map1b lc3 a) (map1a/1b light chain 3 a). [swissprot;acc:q9h492]	Ranked	Divided	56.7252	75.3954	1.32913
	XAB1	xpa binding protein 1; mbd2 interactor protein; putative atp(gtp)-binding protein. [refseq;acc:nm_007266]	Rooted		51.6817	29.5127	1.75117
17	ATG4B	cysteine endopeptidase aut-like isoform b. [refseq;acc:nm_178326]	Ranked		56.7841	75.447	1.32866
	ATPBD1C	protein x 0004. [refseq;acc:nm_016301]	Rooted		51.6817	29.5127	1.75117
	DGCR14	dgcr14 protein (digeorge syndrome critical region 14) (es2 protein). [swissprot;acc:q96df8]	Measured		460	1365	2.96739
			Squared		50.0828	441	8.80542
	GNG5	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-5 subunit. [swissprot;acc:p30670]	Ranked	Subtracted	266.864	336.182	69.318
	MAP1LC3B	microtubule-associated proteins 1a/1b light chain 3b (map1a/map1b lc3 b) (map1a/1b light chain 3 b). [swissprot;acc:q9gzq8]	Measured		24255.7	18168.9	6086.8
	NDN	necdin. [swissprot;acc:q99608]	Squared		219048	129762	89286
	PSCD1	cytohesin 1 (sec7 homolog b2-1). [swissprot;acc:q15438]	Rooted		203.673	182.638	21.035
18	DGCR14	dgcr14 protein (digeorge syndrome critical region 14) (es2 protein). [swissprot;acc:q96df8]		Divided	21.4476	36.9459	1.72261
	GBE1	1,4-alpha-glucan branching enzyme (ec 2.4.1.18) (glycogen branching enzyme) (brancher enzyme). [swissprot;acc:q04446]	Ranked		185.678	245.247	1.32082
	GNG10	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-10 subunit. [swissprot;acc:p50151]		Subtracted	266.865	336.181	69.316
	MAGED1	melanoma-associated antigen d1 (mage-d1 antigen) (neurotrophin receptor-interacting mage homolog) (pro2292). [swissprot;acc:q9y5v3]	Squared		219048	129762	89286
	MAP1LC3A	microtubule-associated proteins 1a/1b light chain 3a (map1a/map1b lc3 a) (map1a/1b light chain 3 a). [swissprot;acc:q9h492]	Measured		24255.7	18168.9	6086.8
	PPP1R14A	protein phosphatase 1, regulatory (inhibitor) subunit 14a; 17-kda pkc-potentiated inhibitory protein of pp1. [refseq;acc:nm_033256]		Divided	677.5	1865.5	2.75351
			Squared		108.641	823.69	7.58176
	PSCD2	cytohesin 2 (arf nucleotide-binding site opener) (arno protein) (arf exchange factor). [swissprot;acc:q99418]	Rooted	Subtracted	203.673	182.638	21.035
19	no value	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-5 like subunit. [swissprot;acc:q9y3k8]	Ranked		266.865	336.178	69.313
	ATG4B	cysteine endopeptidase aut-like isoform b. [refseq;acc:nm_178326]	Measured		24250	18164.9	6085.1
	MAGEF1	melanoma-associated antigen f1 (mage-f1 antigen). [swissprot;acc:q9hay2]	Squared		219048	129762	89286
	MFAP4	microfibril-associated glycoprotein 4 precursor. [swissprot;acc:p55083]	Measured	Divided	677.5	1865.5	2.75351
			Squared		108.641	823.69	7.58176
	PRKRAP1	protein kinase, interferon-inducible double stranded rna dependent activator; protein activator of the interferon-induced protein kinase. [refseq;acc:nm_003690]	Rooted		25.6987	43.561	1.69507

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.