MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	description	Value Type	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 163 to 212 of 6456 in total

Value Type  : Measured
Interaction Map  : High confidence
Filtered  : 1

Rank	description	Network Comparison Type	red	green	network_comparison
82	retinal short-chain dehydrogenase/reductase 3. [refseq;acc:nm_016246]	Subtracted	20446.1	24136.4	3690.3
	small nuclear ribonucleoprotein sm d1 (snrnp core protein d1) (sm-d1) (sm-d autoantigen). [swissprot;acc:p13641]	Divided	4172.91	5954.48	1.42694
83	protein phosphatase inhibitor 2 (ipp-2). [swissprot;acc:p41236]	Subtracted	21644.2	18098.7	3545.5
	proto-oncogene protein c-fos (cellular oncogene fos) (g0/g1 switch regulatory protein 7). [swissprot;acc:p01100]	Divided	4932.27	7033.29	1.42597
84	jun dimerization protein. [refseq;acc:nm_130469]
	type 1 protein phosphatase inhibitor. [refseq;acc:nm_025210]	Subtracted	21632.5	18090	3542.5
85	fos-related antigen 2. [swissprot;acc:p15408]	Divided	4941.95	7037.11	1.42395
	ribosome biogenesis regulatory protein homolog. [swissprot;acc:q15050]	Subtracted	21370.8	17896.5	3474.3
86	protein fosb (g0/g1 switch regulatory protein 3). [swissprot;acc:p53539]	Divided	4942.49	7037.32	1.42384
	serine/threonine protein phosphatase pp1-alpha 1 catalytic subunit (ec 3.1.3.16) (pp-1a). [swissprot;acc:p08129]	Subtracted	21370.8	17896.5	3474.3
87	fos-related antigen 1 (fra-1). [swissprot;acc:p15407]	Divided	4944.3	7038.04	1.42347
	pre-mrna cleavage complex ii protein pcf11 (fragment). [swissprot;acc:o94913]	Subtracted	20287.2	17083.8	3203.4
88	potassium voltage-gated channel, shal-related subfamily, member 2; voltage-sensitive potassium channel; voltage-gated potassium channel kv4.2. [refseq;acc:nm_012281]	Divided	2411.93	1695.45	1.42259
	transforming protein p21a (k-ras 2a) (ki-ras) (c-k-ras). [swissprot;acc:p01116]	Subtracted	16074	12888.4	3185.6
89	cystathionine gamma-lyase (ec 4.4.1.1) (gamma-cystathionase). [swissprot;acc:p32929]	Divided	2414.22	1698.12	1.4217
	leucine-rich repeat protein shoc-2 (ras-binding protein sur-8). [swissprot;acc:q9uq13]	Subtracted	16071.6	12886.8	3184.8
90	potassium voltage-gated channel, shal-related subfamily, member 3 isoform 1; sha1-related potassium channel kv4.3; voltage-gated k+ channel; potassium ionic channel kv4.3; voltage-gated potassium channel kv4.3. [refseq;acc:nm_004980]	Divided	2414.77	1698.75	1.4215
	ral guanine nucleotide dissociation stimulator-like 2 (ralgds-like factor) (ras-associated protein rab2l). [swissprot;acc:o15211]	Subtracted	16071.6	12886.8	3184.8
91	potassium voltage-gated channel, shal-related subfamily, member 1; shal-type potassium channel; voltage-gated potassium channel kv4.1. [refseq;acc:nm_004979]	Divided	2416.53	1700.8	1.42082
	transforming protein p21/h-ras-1 (c-h-ras). [swissprot;acc:p01112]	Subtracted	16070.4	12886	3184.4
92	dj820b18.1 (similar to nuclear cap binding protein) (fragment). [sptrembl;acc:q8wwk2]	Divided	4117.67	5801.04	1.40882
	transforming protein n-ras. [swissprot;acc:p01111]	Subtracted	16069.8	12885.6	3184.2
93	formin binding protein 3; fas-ligand associated factor 1; huntingtin-interacting protein a; ny-ren-6 antigen. [refseq;acc:nm_017892]	Divided	4245.52	5942.75	1.39977
	sedlin. [swissprot;acc:o14582]	Subtracted	17396.9	20483.9	3087
94	huntingtin-interacting protein hypa/fbp11 (fragment). [sptrembl;acc:o75404]	Divided	4247.86	5941.88	1.39879
	synbindin (trs23 homolog) (hematopoietic stem/progenitor cell protein 172) (hspc172) (ptd009) (cgi-104). [swissprot;acc:q9y296]	Subtracted	17396.9	20483.9	3087
95	bet3 homolog. [swissprot;acc:o43617]
	son protein (son3) (negative regulatory element-binding protein) (nre- binding protein) (dbp-5) (bax antagonist selected in saccharomyces 1) (bass1) (protein c21orf50). [swissprot;acc:p18583]	Divided	2397.19	3343.62	1.39481
96	lag1 longevity assurance homolog 2 isoform 1; l3 pigment; tumor metastasis-suppressor. [refseq;acc:nm_022075]		4110.14	5694.99	1.3856
	septin-like protein kiaa0202 (fragment). [swissprot;acc:q92599]	Subtracted	16177.9	19235.4	3057.5
97	amyloid beta a4 precursor protein-binding family a member 1 (neuron- specific x11 protein) (neuronal munc18-1-interacting protein 1) (mint-1) (adapter protein x11alpha). [swissprot;acc:q02410]	Divided	2820.51	3897.1	1.3817
	septin 10 isoform 1. [refseq;acc:nm_144710]	Subtracted	16067.4	19094.4	3027
98	brain protein 44. [swissprot;acc:o95563]		15999.1	19007.1	3008
	presenilin 2 (ps-2) (stm-2) (e5-1) (ad3lp) (ad5). [swissprot;acc:p49810]	Divided	2353.63	3225.65	1.3705
99	s-phase kinase-associated protein 1a (cyclin a/cdk2-associated protein p19) (p19a) (p19skp1) (rna polymerase ii elongation factor-like protein) (organ of corti protein 2) (ocp-ii protein) (ocp-2) (transcription elongation factor b) (siii). [swissprot;acc:p34991]
	septin 7 (cdc10 protein homolog). [swissprot;acc:q16181]	Subtracted	15999.1	19007.1	3008
100	f-box protein fbw7 isoform 2; archipelago, drosophila, homolog of; f-box protein fbw7; f-box protein sel-10; homolog of c elegans sel-10. [refseq;acc:nm_018315]	Divided	2353.63	3225.65	1.3705
	septin 6. [swissprot;acc:q14141]	Subtracted	15959.9	18957.1	2997.2
101	cullin homolog 2 (cul-2). [swissprot;acc:q13617]	Divided	2353.63	3225.65	1.3705
	septin 4 (peanut-like protein 2) (brain protein h5) (cell division control-related protein 2) (hcdcrel-2) (bradeion beta) (ce5b3 beta) (cerebral protein-7) (hucep-7). [swissprot;acc:o43236]	Subtracted	14924.4	17655.2	2730.8
102	associated molecule with the sh3 domain of stam (amsh) like protein. [refseq;acc:nm_020799]		11068	8508.5	2559.5
	presenilin 1 (ps-1) (s182 protein). [swissprot;acc:p49768]	Divided	2353.63	3225.65	1.3705
103	cullin homolog 1 (cul-1). [swissprot;acc:q13616]
	putative breast adenocarcinoma marker (32kd). [refseq;acc:nm_014453]	Subtracted	11068	8508.5	2559.5
104	associated molecule with the sh3 domain of stam. [refseq;acc:nm_006463]
	musashi 2 isoform a. [refseq;acc:nm_138962]	Divided	4241.57	5810.79	1.36996
105	musashi 1. [refseq;acc:nm_002442]
	neuroendocrine differentiation factor; comparative gene identification transcript 149. [refseq;acc:nm_016079]	Subtracted	11068	8508.5	2559.5
106	nuclear protein ukp68. [refseq;acc:nm_024824]	Divided	4241.57	5810.79	1.36996
	protein hspc134 (protein cda04). [swissprot;acc:q9by43]	Subtracted	11068	8508.5	2559.5

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.