MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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description	Rank	Gene	Value Type	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

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Showing element 1001 to 1050 of 3228 in total

Value Type  : Measured
Network Comparison Type  : Divided
Interaction Map  : High confidence
Filtered  : 1

description	Rank	red	green	network_comparison
eyes absent homolog 2. [swissprot;acc:o00167]	2299	5786.15	6050.71	1.04572
eyes absent homolog 3. [swissprot;acc:q99504]	2274	5779.66	6044.78	1.04587
eyes absent homolog 4. [swissprot;acc:o95677]	2296	5784.9	6049.99	1.04582
ezrin-binding partner pace-1 isoform 1. [refseq;acc:nm_020423]	3228	0.00001	0.00001	1
f-actin capping protein alpha-1 subunit (capz alpha-1). [swissprot;acc:p52907]	1490	6340.5	6815.41	1.0749
f-actin capping protein alpha-2 subunit (capz alpha-2). [swissprot;acc:p47755]	1497	6339.08	6812.45	1.07467
f-actin capping protein alpha-3 subunit (capz alpha-3) (germ cell- specific protein 3). [swissprot;acc:q96kx2]	1681	6304.74	6740.66	1.06914
f-actin capping protein beta subunit (capz beta). [swissprot;acc:p47756]	1682
f-box protein fbw7 isoform 2; archipelago, drosophila, homolog of; f-box protein fbw7; f-box protein sel-10; homolog of c elegans sel-10. [refseq;acc:nm_018315]	100	2353.63	3225.65	1.3705
fad synthetase. [refseq;acc:nm_025207]	1841	3591.95	3375.34	1.06417
far upstream element-binding protein; far upstream element binding protein; fuse-binding protein. [refseq;acc:nm_003902]	2092	5817.41	6138.8	1.05525
farnesyl pyrophosphate synthetase (fpp synthetase) (fps) (farnesyl diphosphate synthetase) [includes: dimethylallyltransferase (ec 2.5.1.1); geranyltranstransferase (ec 2.5.1.10)]. [swissprot;acc:p14324]	1180	4392.63	4776.19	1.08732
fas apoptotic inhibitory molecule. [refseq;acc:nm_018147]	2307	5666.91	5923.48	1.04528
fatty acid desaturase 1; linoleoyl-coa desaturase (delta-6-desaturase)-like 1; delta-5 desaturase; delta-5 fatty acid desaturase. [refseq;acc:nm_013402]	2370	5265.95	5492.28	1.04298
fatty acid desaturase 2; linoleoyl-coa desaturase (delta-6-desaturase)-like 2; delta-6 fatty acid desaturase. [refseq;acc:nm_004265]	2369
fatty acid desaturase 3; linoleoyl-coa desaturase (delta-6-desaturase)-like 3; delta-6 fatty acid desaturase. [refseq;acc:nm_021727]	2367
fatty acid hydroxylase domain containing 1. [refseq;acc:nm_024306]	2204	5076.73	5326.29	1.04916
fatty acid-binding protein, adipocyte (afabp) (adipocyte lipid-binding protein) (albp) (a-fabp). [swissprot;acc:p15090]	1665	5791.14	6193.02	1.0694
fatty acid-binding protein, brain (b-fabp) (brain lipid-binding protein) (blbp) (mammary derived growth inhibitor related). [swissprot;acc:o15540]	1667
fatty acid-binding protein, epidermal (e-fabp) (psoriasis-associated fatty acid-binding protein homolog) (pa-fabp). [swissprot;acc:q01469]	1666
fatty acid-binding protein, heart (h-fabp) (muscle fatty acid-binding protein) (m-fabp) (mammary-derived growth inhibitor) (mdgi). [swissprot;acc:p05413]	1674
fatty aldehyde dehydrogenase (ec 1.2.1.3) (aldehyde dehydrogenase, microsomal) (aldh class 3). [swissprot;acc:p51648]	3181	0.00001	0.00001	1
fatty-acid amide hydrolase (ec 3.1.-.-) (oleamide hydrolase) (anandamide amidohydrolase). [swissprot;acc:o00519]	1951	5888.32	6245.89	1.06073
fem-1 homolog b; fem-1-like death receptor binding protein; fem-1 (c.elegans) homolog b. [refseq;acc:nm_015322]	403	5201.41	4479.76	1.16109
ferritin heavy chain (ferritin h subunit). [swissprot;acc:p02794]	620	6227.87	7012.9	1.12605
ferritin heavy polypeptide-like 17. [swissprot;acc:q9bxu8]	635	6228.97	7013.53	1.12595
ferritin light chain (ferritin l subunit). [swissprot;acc:p02792]	633	6228.39	7013.19	1.126
ferrochelatase, mitochondrial precursor (ec 4.99.1.1) (protoheme ferro-lyase) (heme synthetase). [swissprot;acc:p22830]	3185	0.00001	0.00001	1
fetal brain protein 239 (239fb). [swissprot;acc:q15777]	1053	4757.46	5198.91	1.09279
fibrillarin (34 kda nucleolar scleroderma antigen). [swissprot;acc:p22087]	646	4019.88	4522.61	1.12506
fibrillin 1 precursor. [swissprot;acc:p35555]	2844	0.00001	0.00001	1
fibrillin 2 precursor. [swissprot;acc:p35556]	2955
fibrillin 3. [refseq;acc:nm_032447]	2939
fibulin-1 precursor. [swissprot;acc:p23142]	1304	8550.79	9248.06	1.08154
fibulin-2 precursor. [swissprot;acc:p98095]	1216	8670.59	9412.9	1.08561
ficolin 2 precursor (collagen/fibrinogen domain-containing protein 2) (ficolin-b) (ficolin b) (serum lectin p35) (ebp-37) (hucolin) (l- ficolin). [swissprot;acc:q15485]	21	677.5	1865.5	2.75351
fidgetin-like 1. [refseq;acc:nm_022116]	1491	6057.46	6510.9	1.07486
filamin a (alpha-filamin) (filamin 1) (endothelial actin-binding protein) (abp-280) (nonmuscle filamin). [swissprot;acc:p21333]	113	4366.44	5899.76	1.35116
filamin b, beta (actin binding protein 278); beta filamin; filamin 1 (actin-binding protein-280)-like; filamin b, beta (actin-binding protein-278); filamin b, beta. [refseq;acc:nm_001457]	108
fip1-like 1; rearranged in hypereosinophilia. [refseq;acc:nm_030917]	270	23640.2	19479.8	1.21358
fk506-binding protein 1a (ec 5.2.1.8) (peptidyl-prolyl cis-trans isomerase) (ppiase) (rotamase) (12 kda fkbp) (fkbp-12) (immunophilin fkbp12). [swissprot;acc:p20071]	1207	5946.33	6459.79	1.08635
flap endonuclease-1 (ec 3.-.-.-) (maturation factor 1) (mf1). [swissprot;acc:p39748]	2831	0.00001	0.00001	1
flavoprotein oxidoreductase mical2. [refseq;acc:nm_014632]	556	6167.93	7007.7	1.13615
flotillin-1. [swissprot;acc:o75955]	1296	5655.85	6120.64	1.08218
folylpolyglutamate synthase, mitochondrial precursor (ec 6.3.2.17) (folylpoly-gamma-glutamate synthetase) (fpgs). [swissprot;acc:q05932]	2009	4934.48	5223.69	1.05861
forkhead box p4; fork head-related protein like a; winged-helix repressor foxp4. [refseq;acc:nm_138457]	130	2234.68	2978.53	1.33287
forkhead box protein g1c (forkhead-related protein fkhl3) (hfk3) (fragment). [swissprot;acc:q14488]	578	6739.81	7644.62	1.13425
forkhead box protein p1 (hspc215). [swissprot;acc:q9h334]	131	2234.73	2978.57	1.33285
forkhead box protein p3 (zinc finger protein jm2) (scurfin). [swissprot;acc:q9bzs1]	132	2236.61	2980.35	1.33253
formin binding protein 3; fas-ligand associated factor 1; huntingtin-interacting protein a; ny-ren-6 antigen. [refseq;acc:nm_017892]	93	4245.52	5942.75	1.39977

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.