MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	description	Value Type	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 1251 to 1300 of 6456 in total

Value Type  : Ranked
Interaction Map  : High confidence
Filtered  : 1

Rank	description	Network Comparison Type	red	green	network_comparison
626	gamma-aminobutyric-acid receptor epsilon subunit precursor (gaba(a) receptor). [swissprot;acc:p78334]	Divided	214.256	202.14	1.05994
	hairy/enhancer-of-split related with yrpw motif-like. [refseq;acc:nm_014571]	Subtracted	229.072	216.576	12.496
627	phosphatidylserine receptor; phosphatidylserine receptor beta. [refseq;acc:nm_015167]	Divided	214.256	202.139	1.05994
	synapsin ii. [swissprot;acc:q92777]	Subtracted	229.072	216.576	12.496
628	gamma-aminobutyric-acid receptor alpha-1 subunit precursor (gaba(a) receptor). [swissprot;acc:p14867]	Divided	214.256	202.14	1.05994
	mitochondrial ribosome recycling factor. [refseq;acc:nm_138777]	Subtracted	229.072	216.576	12.496
629	gamma-aminobutyric-acid receptor alpha-3 subunit precursor (gaba(a) receptor). [swissprot;acc:p34903]	Divided	214.256	202.14	1.05994
	peroxisomal targeting signal 1 receptor (peroxismore receptor 1) (peroxisomal c-terminal targeting signal import receptor) (pts1-bp) (peroxin-5) (pts1 receptor). [swissprot;acc:p50542]	Subtracted	229.072	216.576	12.496
630	hairy/enhancer-of-split related with yrpw motif 2; gridlock; hes-related repressor protein 1. [refseq;acc:nm_012259]
	nadh-ubiquinone oxidoreductase b14 subunit (ec 1.6.5.3) (ec 1.6.99.3) (complex i-b14) (ci-b14). [swissprot;acc:p56556]	Divided	214.256	202.141	1.05993
631	similar to expressed sequence aa415817. [sptrembl;acc:q8n4q9]
	transcription factor hes-1 (hairy and enhancer of split 1) (hairy- like) (hhl) (hairy homolog). [swissprot;acc:q14469]	Subtracted	229.072	216.576	12.496
632	delta3,5-delta2,4-dienoyl-coa isomerase, mitochondrial precursor (ec 5.3.3.-). [swissprot;acc:q13011]
	homeobox protein hox-d9 (hox-4c) (hox-5.2). [swissprot;acc:p28356]	Divided	214.254	202.166	1.05979
633	actin-binding lim protein 1 isoform a; lim actin-binding protein 1; limatin; actin-binding lim protein. [refseq;acc:nm_002313]	Subtracted	229.072	216.576	12.496
	alanyl-trna synthetase (ec 6.1.1.7) (alanine--trna ligase) (alars). [swissprot;acc:p49588]	Divided	234.106	248.104	1.05979
634	dead-box protein abstrakt homolog. [swissprot;acc:q9ujv9]		226.523	213.786	1.05958
	synapsin i (brain protein 4.1). [swissprot;acc:p17600]	Subtracted	229.072	216.576	12.496
635	60s ribosomal protein l37 (g1.16). [swissprot;acc:p02403]	Divided	228.639	242.258	1.05957
	mevalonate kinase (ec 2.7.1.36) (mk). [swissprot;acc:q03426]	Subtracted	235.296	247.673	12.377
636	splicing factor, arginine/serine-rich 1 (pre-mrna splicing factor sf2, p33 subunit) (alternative splicing factor asf-1). [swissprot;acc:q07955]	Divided	228.639	242.258	1.05957
	vav proto-oncogene. [swissprot;acc:p15498]	Subtracted	212.2	199.849	12.351
637	amidophosphoribosyltransferase precursor (ec 2.4.2.14) (glutamine phosphoribosylpyrophosphate amidotransferase) (atase) (gpat). [swissprot;acc:q06203]	Divided	228.639	242.258	1.05957
	vav-3 protein. [swissprot;acc:q9ukw4]	Subtracted	212.253	199.908	12.345
638	sorting nexin 17. [swissprot;acc:q15036]	Divided	228.639	242.258	1.05957
	vav-2 protein. [swissprot;acc:p52735]	Subtracted	212.526	200.212	12.314
639	nucleoporin-like protein rip (hiv-1 rev-binding protein) (rev interacting protein) (rev/rex activation domain-binding protein). [swissprot;acc:p52594]	Divided	217.67	230.596	1.05938
	rna-binding protein nova-1 (neuro-oncological ventral antigen 1) (onconeural ventral antigen-1) (paraneoplastic ri antigen) (ventral neuron-specific protein 1). [swissprot;acc:p51513]	Subtracted	222.554	234.847	12.293
640	histone h3.3 (h3.a) (h3.b) (h3.3q). [swissprot;acc:p06351]		244.842	232.577	12.265
	intersectin 1 (sh3 domain-containing protein 1a) (sh3p17). [swissprot;acc:q15811]	Divided	217.67	230.596	1.05938
641	dj1099d15.1 (putative dnaj protein). [sptrembl;acc:q9h4j9]	Subtracted	244.842	232.577	12.265
	pram-1 protein; pml-rara target gene encoding an adaptor molecule-1. [refseq;acc:nm_032152]	Divided	217.67	230.596	1.05938
642	intersectin 2 (sh3 domain-containing protein 1b) (sh3p18) (sh3p18-like wasp associated protein). [swissprot;acc:q9nzm3]
	u6 snrna-associated sm-like protein lsm4 (glycine-rich protein) (grp). [swissprot;acc:q9y4z0]	Subtracted	228.944	216.745	12.199
643	hiv-1 rev binding protein-like; rev/rex activation domain binding protein-related. [refseq;acc:nm_006076]	Divided	217.67	230.596	1.05938
	methionyl-trna synthetase (ec 6.1.1.10) (methionine--trna ligase) (metrs). [swissprot;acc:p56192]	Subtracted	218.227	206.078	12.149
644	cgthba protein (-14 gene protein). [swissprot;acc:q12980]	Divided	217.67	230.596	1.05938
	peripheral plasma membrane protein cask (ec 2.7.1.-) (hcask) (calcium/calmodulin-dependent serine protein kinase) (lin-2 homolog). [swissprot;acc:o14936]	Subtracted	226.497	214.355	12.142
645	hiv tat specific factor 1; cofactor required for tat activation of hiv-1 transcription. [refseq;acc:nm_014500]	Divided	217.67	230.596	1.05938
	hypoxia-inducible factor-3 alpha isoform a; inhibitory pas domain protein. [refseq;acc:nm_152794]	Subtracted	226.497	214.355	12.142
646	short coiled-coil protein; short coiled coil protein. [refseq;acc:nm_032547]	Divided	216.731	229.549	1.05914
	single-minded homolog 1. [swissprot;acc:p81133]	Subtracted	226.497	214.355	12.142
647	dynein light chain 2. [refseq;acc:nm_080677]	Divided	216.731	229.549	1.05914
	homeobox protein hox-a10 (hox-1h) (hox-1.8) (pl). [swissprot;acc:p31260]	Subtracted	214.257	202.125	12.132
648	homeobox protein hox-b9 (hox-2e) (hox-2.5). [swissprot;acc:p17482]			202.132	12.125
	methionyl-trna synthetase (ec 6.1.1.10) (methionine--trna ligase) (metrs). [swissprot;acc:p56192]	Divided	218.227	206.078	1.05895
649	eukaryotic translation initiation factor 4e (eif-4e) (eif4e) (mrna cap-binding protein) (eif-4f 25 kda subunit). [swissprot;acc:p06730]		233.725	220.751	1.05877
	homeobox protein hox-a9 (hox-1g). [swissprot;acc:p31269]	Subtracted	214.257	202.132	12.125
650	homeobox protein hox-c9 (hox-3b). [swissprot;acc:p31274]			202.135	12.122
	u6 snrna-associated sm-like protein lsm7. [swissprot;acc:q9uk45]	Divided	228.986	216.276	1.05877

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.