MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Filtered	Gene	Value Type	Rank	description	green	Interaction Map	red	network_comparison	Network Comparison Type

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Showing element 1 to 50 of 77072 in total

Filtered  : 0
Value Type  : Measured

Rank	description	green	Interaction Map	red	network_comparison	Network Comparison Type
1	ba508n22.1 (hspc025) (fragment). [sptrembl;acc:q9hcw5]	6410	High confidence	85	6325	Subtracted
			Low confidence
	mitochondrial 28s ribosomal protein s32 (s32mt) (mrp-s32) (ptd007) (hspc204). [swissprot;acc:q9y6g3]	0.00001	High confidence	364	36400000	Divided
			Low confidence
2	cab2. [refseq;acc:nm_033419]	174	High confidence	0.00001	17400000
	homeobox protein hox-c4 (hox-3e) (cp19). [swissprot;acc:p09017]	89	Low confidence		8900000
	lipopolysaccharide-responsive and beige-like anchor protein (cdc4-like protein) (beige-like protein). [swissprot;acc:p50851]	6410	High confidence	85	6325	Subtracted
	nuclear dna-binding protein; small unique nuclear receptor corepressor; c1d dna-binding protein. [refseq;acc:nm_006333]	19621.3	Low confidence	23818.1	4196.8
3	homeobox protein hox-c6 (hox-3c) (hho.c8) (cp25). [swissprot;acc:p09630]	89		0.00001	8900000	Divided
	nuclear dna-binding protein; small unique nuclear receptor corepressor; c1d dna-binding protein. [refseq;acc:nm_006333]	19621.3	High confidence	23818.1	4196.8	Subtracted
	nucleoporin nup43 (p42). [swissprot;acc:q8nfh3]	7500.75	Low confidence	5106.93	2393.82
	pyridoxine 5'-phosphate oxidase. [refseq;acc:nm_018129]	109	High confidence	0.00001	10900000	Divided
4	anchor attachment protein 1; glycophosphatidylinositol anchor attachment 1; anchor attachment protein 1 (gaa1p, yeast) homolog. [refseq;acc:nm_003801]	4356	Low confidence	2082	2274	Subtracted
	homeobox protein hox-a4 (hox-1d) (hox-1.4). [swissprot;acc:q00056]	89		0.00001	8900000	Divided
	homeobox protein hox-c4 (hox-3e) (cp19). [swissprot;acc:p09017]		High confidence
	small nuclear ribonucleoprotein e (snrnp-e) (sm protein e) (sm-e) (sme). [swissprot;acc:p08578]	21730		18704	3026	Subtracted
5	histone h4. [swissprot;acc:p02304]	24446.3		21773.1	2673.2
	homeobox protein hox-c6 (hox-3c) (hho.c8) (cp25). [swissprot;acc:p09630]	89		0.00001	8900000	Divided
	jumonji protein. [swissprot;acc:q92833]	17.5166	Low confidence		1751660
	lipopolysaccharide-responsive and beige-like anchor protein (cdc4-like protein) (beige-like protein). [swissprot;acc:p50851]	2740.13		485.286	2254.84	Subtracted
6	homeobox protein hox-a4 (hox-1d) (hox-1.4). [swissprot;acc:q00056]	89	High confidence	0.00001	8900000	Divided
	homogentisate 1,2-dioxygenase (ec 1.13.11.5) (homogentisicase) (homogentisate oxygenase) (homogentisic acid oxidase). [swissprot;acc:q93099]	0.00001	Low confidence	13	1300000
	similar to zinc finger protein 277. [sptrembl;acc:q8wwa6]	8836.85		7592.37	1244.48	Subtracted
		15605.1	High confidence	13174.7	2430.4
7	cysteine endopeptidase aut-like 2 isoform a; autophagy-related cysteine endopeptidase 2; autophagin 2. [refseq;acc:nm_052936]	5898.71	Low confidence	4660.09	1238.62
	sedlin. [swissprot;acc:o14582]	43	High confidence	0.00001	4300000	Divided
	tbc1 domain family, member 8 (with gram domain); vascular rab-gap/tbc-containing. [refseq;acc:nm_007063]	0.00001	Low confidence	2.31962	231962
	zinc finger protein 277. [swissprot;acc:q9nrm2]	15605.1	High confidence	13174.7	2430.4	Subtracted
8	ba508n22.1 (hspc025) (fragment). [sptrembl;acc:q9hcw5]	6410	Low confidence	85	75.4118	Divided
	nucleoporin nup43 (p42). [swissprot;acc:q8nfh3]	7500.75	High confidence	5106.93	2393.82	Subtracted
	synbindin (trs23 homolog) (hematopoietic stem/progenitor cell protein 172) (hspc172) (ptd009) (cgi-104). [swissprot;acc:q9y296]	43		0.00001	4300000	Divided
	zinc finger protein 277. [swissprot;acc:q9nrm2]	8770.72	Low confidence	7537.89	1232.83	Subtracted
9	ataxin 2; olivopontocerebellar ataxia 2, autosomal dominant. [refseq;acc:nm_002973]	11468.3		10255.7	1212.6
		14756	High confidence	12478	2278
	ba508n22.1 (hspc025) (fragment). [sptrembl;acc:q9hcw5]	6410		85	75.4118	Divided
	ubiquitously transcribed y chromosome tetratricopeptide repeat protein (ubiquitously transcribed tpr protein on the y chromosome). [swissprot;acc:o14607]	10.6048	Low confidence	383.762	36.1876
10	dj570f3.6 (novel protein similar to lysophospholipase ii (lypla2)). [sptrembl;acc:q9uge0]	2804		1593	1211	Subtracted
	lipopolysaccharide-responsive and beige-like anchor protein (cdc4-like protein) (beige-like protein). [swissprot;acc:p50851]	6410	High confidence	85	75.4118	Divided
	myosin va (myosin 5a) (dilute myosin heavy chain, non-muscle) (myosin heavy chain 12) (myoxin). [swissprot;acc:q9y4i1]	6193.07		7830.62	1637.55	Subtracted
	serpin b12. [swissprot;acc:q96p63]	5.56738	Low confidence	199.549	35.8425	Divided
11	cysteine endopeptidase aut-like 2 isoform a; autophagy-related cysteine endopeptidase 2; autophagin 2. [refseq;acc:nm_052936]	7252.02	High confidence	5734.28	1517.74	Subtracted
	cysteine endopeptidase aut-like isoform b. [refseq;acc:nm_178326]	5341.81	Low confidence	4230.36	1111.45
	hurpin (hacat uv-repressible serpin) (protease inhibitor 13) (headpin) (serpin b13). [swissprot;acc:q9uiv8]	5.71669		199.249	34.8539	Divided
	serpin b12. [swissprot;acc:q96p63]	5.56738	High confidence	199.549	35.8425
12	cysteine endopeptidase aut-like isoform b. [refseq;acc:nm_178326]	7099.51		5629.62	1469.89	Subtracted
	hurpin (hacat uv-repressible serpin) (protease inhibitor 13) (headpin) (serpin b13). [swissprot;acc:q9uiv8]	5.71669		199.249	34.8539	Divided
	mln 64 protein (star-related lipid transfer protein 3) (stard3) (start domain-containing protein 3) (cab1 protein). [swissprot;acc:q14849]	58	Low confidence	859	14.8103
	transcription initiation factor tfiid 135 kda subunit (tafii-135) (tafii135) (tafii-130) (tafii130). [swissprot;acc:o00268]	30022.4		31122	1099.6	Subtracted
13	adp-ribosylation factor gtpase-activating protein 3 (arf gap 3). [swissprot;acc:q9np61]	47	High confidence	1363	29	Divided
					1316	Subtracted

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.