MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	description	Value Type	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 358 to 407 of 6456 in total

Value Type  : Ranked
Interaction Map  : High confidence
Filtered  : 1

Rank	description	Network Comparison Type	red	green	network_comparison
179	phenylalanine-4-hydroxylase (ec 1.14.16.1) (pah) (phe-4- monooxygenase). [swissprot;acc:p00439]	Subtracted	227.357	254.15	26.793
180	pp3111 protein. [refseq;acc:nm_022156]
	tar dna-binding protein-43 (tdp-43). [swissprot;acc:q13148]	Divided	256.228	298.438	1.16474
181	b9 protein; likely ortholog of mouse endothelial precursor protein b9. [refseq;acc:nm_015681]		229.818	267.265	1.16294
	syntaxin 18. [swissprot;acc:q9p2w9]	Subtracted	227.357	254.15	26.793
182	histone acetyltransferase type b catalytic subunit (ec 2.3.1.48). [swissprot;acc:o14929]	Divided	277.546	240.461	1.15422
	rd protein. [swissprot;acc:p18615]	Subtracted	227.357	254.15	26.793
183	20 kda nuclear cap binding protein (ncbp 20 kda subunit) (cbp20) (ncbp interacting protein 1) (nip1). [swissprot;acc:p52298]	Divided	228.306	198.011	1.153
	glutathione transferase omega 1 (ec 2.5.1.18) (gsto 1-1). [swissprot;acc:p78417]	Subtracted	227.357	254.15	26.793
184	androgen-induced 1; cgi-103 protein; androgen induced protein. [refseq;acc:nm_016108]
	odd-skipped related 1; odz (odd oz/ten-m) related 1. [refseq;acc:nm_145260]	Divided	274.027	237.79	1.15239
185	adiponectin receptor 2. [refseq;acc:nm_024551]		281.582	246.371	1.14292
	atp synthase b chain, mitochondrial precursor (ec 3.6.3.14). [swissprot;acc:p24539]	Subtracted	227.357	254.15	26.793
186	filamin b, beta (actin binding protein 278); beta filamin; filamin 1 (actin-binding protein-280)-like; filamin b, beta (actin-binding protein-278); filamin b, beta. [refseq;acc:nm_001457]	Divided	226.582	198.444	1.14179
	j domain containing protein 1. [swissprot;acc:q9ukb3]	Subtracted	227.357	254.15	26.793
187	rev1-like; rev1 protein; rev1 (yeast homolog)- like. [refseq;acc:nm_016316]	Divided	226.582	198.444	1.14179
	sorting nexin 13 (rgs domain- and phox domain-containing protein) (rgs-px1). [swissprot;acc:q9y5w8]	Subtracted	227.357	254.15	26.793
188	ba127l20.1 (novel glutathione-s-transferase). [sptrembl;acc:q9h4y5]
	protein arginine n-methyltransferase 1 (ec 2.1.1.-) (interferon receptor 1-bound protein 4). [swissprot;acc:q99873]	Divided	226.582	198.444	1.14179
189	cholinephosphate cytidylyltransferase a (ec 2.7.7.15) (phosphorylcholine transferase a) (ctp:phosphocholine cytidylyltransferase a) (ct a) (cct a) (cct-alpha). [swissprot;acc:p49585]	Subtracted	241.373	267.352	25.979
	protein arginine n-methyltransferase 4 (ec 2.1.1.-). [swissprot;acc:q9nr22]	Divided	226.582	198.444	1.14179
190	fad synthetase. [refseq;acc:nm_025207]	Subtracted	241.373	267.352	25.979
	u1 small nuclear ribonucleoprotein 70 kda (u1 snrnp 70 kda) (snrnp70) (u1-70k). [swissprot;acc:p08621]	Divided	226.582	198.444	1.14179
191	bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthethase 2 (paps synthethase 2) (papss 2) (sulfurylase kinase 2) (sk2) (sk 2) [includes: sulfate adenylyltransferase (ec 2.7.7.4) (sulfate adenylate transferase) (sat) (atp-sulfurylase); adenylylsulfate kinase (ec 2.7.1.25) (adenylylsulfate 3'-phosphotransferase) (aps kinase) (adenosine-5'-phosphosulfate 3'-phosphotransferase) (3'- phosphoadenosine-5'-phosphosulfate synthetase)]. [swissprot;acc:o95340]	Subtracted	241.373	267.352	25.979
	filamin a (alpha-filamin) (filamin 1) (endothelial actin-binding protein) (abp-280) (nonmuscle filamin). [swissprot;acc:p21333]	Divided	226.582	198.444	1.14179
192	ligatin (hepatocellular carcinoma-associated antigen 56). [swissprot;acc:p41214]	Subtracted	241.373	267.352	25.979
	musashi 2 isoform a. [refseq;acc:nm_138962]	Divided	227.491	199.458	1.14055
193	bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthethase 1 (paps synthethase 1) (papss 1) (sulfurylase kinase 1) (sk1) (sk 1) [includes: sulfate adenylyltransferase (ec 2.7.7.4) (sulfate adenylate transferase) (sat) (atp-sulfurylase); adenylylsulfate kinase (ec 2.7.1.25) (adenylylsulfate 3'-phosphotransferase) (aps kinase) (adenosine-5'-phosphosulfate 3'-phosphotransferase) (3'- phosphoadenosine-5'-phosphosulfate synthetase)]. [swissprot;acc:o43252]	Subtracted	241.373	267.352	25.979
	musashi 1. [refseq;acc:nm_002442]	Divided	227.491	199.458	1.14055
194	nadph-cytochrome p450 reductase (ec 1.6.2.4) (cpr) (p450r). [swissprot;acc:p16435]	Subtracted	241.373	267.352	25.979
	nuclear protein ukp68. [refseq;acc:nm_024824]	Divided	227.491	199.458	1.14055
195	cholinephosphate cytidylyltransferase b (ec 2.7.7.15) (phosphorylcholine transferase b) (ctp:phosphocholine cytidylyltransferase b) (ct b) (cct b) (cct-beta). [swissprot;acc:q9y5k3]	Subtracted	241.373	267.352	25.979
	huntingtin interacting protein c. [refseq;acc:nm_012272]	Divided	227.971	200.417	1.13748
196	forkhead box p4; fork head-related protein like a; winged-helix repressor foxp4. [refseq;acc:nm_138457]		263.215	231.407	1.13745
	hpaii tiny fragments locus 9c. [refseq;acc:nm_022727]	Subtracted	272.781	246.892	25.889
197	60s ribosomal protein l32. [swissprot;acc:p02433]		241.13	266.969	25.839
	forkhead box protein p1 (hspc215). [swissprot;acc:q9h334]	Divided	263.215	231.407	1.13745
198	40s ribosomal protein s29. [swissprot;acc:p30054]	Subtracted	241.849	267.642	25.793
	forkhead box protein p3 (zinc finger protein jm2) (scurfin). [swissprot;acc:q9bzs1]	Divided	263.191	231.394	1.13741
199	40s ribosomal protein s11. [swissprot;acc:p04643]	Subtracted	241.399	267.088	25.689
	palmitoyl-protein thioesterase 2 precursor (ec 3.1.2.22) (palmitoyl- protein hydrolase 2) (ppt-2) (g14). [swissprot;acc:q9umr5]	Divided	242.735	276.059	1.13729
200	60s ribosomal protein l17 (l23). [swissprot;acc:p18621]	Subtracted	241.808	267.335	25.527
	egf-like-domain, multiple 7; neu1 protein. [refseq;acc:nm_016215]	Divided	242.718	276.018	1.1372
201	60s ribosomal protein l11. [swissprot;acc:p39026]	Subtracted	241.828	267.346	25.518
	splicing factor 4 isoform b; rna-binding protein. [refseq;acc:nm_021164]	Divided	240.133	211.382	1.13601
202	40s ribosomal protein s4, y isoform 2. [swissprot;acc:q8td47]	Subtracted	240.758	266.079	25.321
	short transient receptor potential channel 4 (trpc4) (trp-related protein 4) (htrp-4) (htrp4). [swissprot;acc:q9ubn4]	Divided	201.478	228.784	1.13553
203	40s ribosomal protein s4, x isoform (single copy abundant mrna protein) (scr10). [swissprot;acc:p12750]	Subtracted	240.758	266.078	25.32
	ebp50-pdz interactor of 64 kda (epi64 protein). [swissprot;acc:q9bxi6]	Divided	201.515	228.752	1.13516
204	calpain 2, large [catalytic] subunit precursor (ec 3.4.22.17) (calcium-activated neutral proteinase) (canp) (m-type) (m-calpain) (millimolar-calpain) (calpain large polypeptide l2). [swissprot;acc:p17655]	Subtracted	268.632	243.588	25.044

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.