MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Gene	Rank	description	Value Type	green	Network Comparison Type	red	Interaction Map	Filtered	network_comparison

Results: HTML CSV LaTeX

Showing element 51 to 100 of 25824 in total

Interaction Map  : High confidence
Filtered  : 1

Rank	description	Value Type	green	Network Comparison Type	red	network_comparison
7	nuclear dna-binding protein; small unique nuclear receptor corepressor; c1d dna-binding protein. [refseq;acc:nm_006333]	Squared	442993	Subtracted	310840	132153
	pantothenate kinase 2, mitochondrial precursor (ec 2.7.1.33) (pantothenic acid kinase 2) (hpank2). [swissprot;acc:q9bz23]	Rooted	168.796		145.551	23.245
	protein cgi-126 (protein hspc155). [swissprot;acc:q9y3c8]	Ranked	212.554		288.754	76.2
	sphingomyelin phosphodiesterase 2 (ec 3.1.4.12) (neutral sphingomyelinase) (nsmase) (n-smase) (lyso-platelet activating factor- phospholipase c) (lyso-paf-plc). [swissprot;acc:o60906]	Measured	339.5	Divided	1153.5	3.39764
		Squared	27.2805		314.926	11.544
		Rooted	18.4255		33.9632	1.84327
8	db83 protein. [swissprot;acc:p57088]	Measured	339.5		1153.5	3.39764
		Squared	27.2805		314.926	11.544
		Rooted	18.4255		33.9632	1.84327
	deoxyribonuclease ii beta isoform 1 precursor; deoxyribonuclease ii beta; endonuclease dlad. [refseq;acc:nm_021233]	Squared	354894	Subtracted	250303	104591
	hbs1-like. [refseq;acc:nm_006620]	Ranked	322	Divided	215	1.49767
	junctophilin 3 (junctophilin type 3) (jp-3). [swissprot;acc:q8wxh2]		362	Subtracted	288	74
	pantothenate kinase 1 (ec 2.7.1.33) (pantothenic acid kinase 1) (hpank1) (hpank). [swissprot;acc:q8te04]	Measured	28492		21185	7307
	pantothenate kinase 3 (ec 2.7.1.33) (pantothenic acid kinase 3) (hpank3). [swissprot;acc:q9h999]	Rooted	168.796		145.551	23.245
9	junctophilin 2 (junctophilin type 2) (jp-2). [swissprot;acc:q9br39]	Ranked	362		288	74
	mitochondrial solute carrier protein. [refseq;acc:nm_145305]	Rooted	168.796		145.551	23.245
	pantothenate kinase 2, mitochondrial precursor (ec 2.7.1.33) (pantothenic acid kinase 2) (hpank2). [swissprot;acc:q9bz23]	Measured	28492		21185	7307
	protein phosphatase 1, regulatory subunit 7; sds22. [refseq;acc:nm_002712]	Squared	162517		256169	93652
	tob2 protein (transducer of erbb-2 2). [swissprot;acc:q14106]	Measured	1281.5	Divided	398.5	3.21581
		Squared	388.696		37.5863	10.3414
		Rooted	35.798		19.9625	1.79326
	xpa binding protein 1; mbd2 interactor protein; putative atp(gtp)-binding protein. [refseq;acc:nm_007266]	Ranked	309		212	1.45755
10	melanoma antigen, family d, 4 isoform 1; mage1 protein; mage-e1 protein; maged4 protein. [refseq;acc:nm_030801]	Squared	129762	Subtracted	219048	89286
	pantothenate kinase 3 (ec 2.7.1.33) (pantothenic acid kinase 3) (hpank3). [swissprot;acc:q9h999]	Measured	28492		21185	7307
	protein x 0004. [refseq;acc:nm_016301]	Ranked	309	Divided	212	1.45755
	sphingomyelin phosphodiesterase 2 (ec 3.1.4.12) (neutral sphingomyelinase) (nsmase) (n-smase) (lyso-platelet activating factor- phospholipase c) (lyso-paf-plc). [swissprot;acc:o60906]		362	Subtracted	288	74
	tob1 protein (transducer of erbb-2 1). [swissprot;acc:p50616]	Measured	1281.5	Divided	398.5	3.21581
		Squared	388.696		37.5863	10.3414
		Rooted	35.798		19.9625	1.79326
	xpa binding protein 1; mbd2 interactor protein; putative atp(gtp)-binding protein. [refseq;acc:nm_007266]		29.5127	Subtracted	51.6817	22.169
11	dab2 interacting protein; ngap-like protein; doc-2/dab2 interactive protein. [refseq;acc:nm_032552]	Measured	1281.5	Divided	398.5	3.21581
		Squared	388.696		37.5863	10.3414
		Rooted	35.798		19.9625	1.79326
	db83 protein. [swissprot;acc:p57088]	Ranked	362	Subtracted	288	74
	hepatocellular carcinoma-associated protein hca3. [refseq;acc:nm_138703]	Squared	129762		219048	89286
	mitochondrial solute carrier protein. [refseq;acc:nm_145305]	Measured	28492		21185	7307
	protein x 0004. [refseq;acc:nm_016301]	Rooted	29.5127		51.6817	22.169
	rad50-interacting protein 1. [refseq;acc:nm_021930]	Ranked	232	Divided	337	1.45259
12	beta-arrestin 2 (arrestin, beta 2). [swissprot;acc:p32121]	Rooted	101.526	Subtracted	80.4705	21.0555
	cytoplasmic polyadenylation element binding protein 4. [refseq;acc:nm_030627]	Measured	1281.5	Divided	398.5	3.21581
		Squared	388.696		37.5863	10.3414
		Rooted	35.798		19.9625	1.79326
	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-7 subunit. [swissprot;acc:o60262]	Ranked	336.233	Subtracted	266.856	69.377
	melanoma-associated antigen 3 (mage-3 antigen) (antigen mz2-d). [swissprot;acc:p43357]	Squared	129762		219048	89286
	nuclear dna-binding protein; small unique nuclear receptor corepressor; c1d dna-binding protein. [refseq;acc:nm_006333]	Measured	40795.8		34190.9	6604.9
	rho-related btb domain-containing protein 2 (deleted in breast cancer 2 gene protein) (p83). [swissprot;acc:q9byz6]	Ranked	232	Divided	337	1.45259
13	beta-arrestin 1 (arrestin, beta 1). [swissprot;acc:p49407]	Rooted	101.526	Subtracted	80.4705	21.0555
	cytoplasmic polyadenylation element binding protein 3. [refseq;acc:nm_014912]	Measured	1281.5	Divided	398.5	3.21581
		Squared	388.696		37.5863	10.3414
		Rooted	35.798		19.9625	1.79326

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.