MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Gene	Rank	Filtered	Network Comparison Type	description	Value Type	Interaction Map	green	red	network_comparison

Results: HTML CSV LaTeX

Showing element 601 to 650 of 3730 in total

Network Comparison Type  : Divided
Value Type  : Ranked
Interaction Map  : High confidence

Rank	Filtered	description	green	red	network_comparison
301	0	sh2-b homolog; likely ortholog of mouse sh2 domain-containing putative adapter sh2-b; sh2-b gamma signaling protein; sh2-b alpha signaling protein. [refseq;acc:nm_015503]	13698	12783	1.07158
	1	beta-1,4 mannosyltransferase. [refseq;acc:nm_019109]	166.372	150.982	1.10193
302	0	guanine nucleotide-binding protein beta subunit-like protein 12.3 (p205) (receptor of activated protein kinase c 1) (rack1) (receptor for activated c kinase). [swissprot;acc:p25388]	6895.44	7386.71	1.07125
	1	60s ribosomal protein l26. [swissprot;acc:q02877]	267.008	242.326	1.10185
303	0	intersectin 2 (sh3 domain-containing protein 1b) (sh3p18) (sh3p18-like wasp associated protein). [swissprot;acc:q9nzm3]	12244.1	11431.4	1.07109
	1	60s ribosomal protein l35. [swissprot;acc:p42766]	266.999	242.333	1.10179
304	0	sprouty homolog 4 (spry-4). [swissprot;acc:q9c004]	7496.8	8021.78	1.07003
	1	40s ribosomal protein s15 (rig protein). [swissprot;acc:p11174]	266.986	242.339	1.1017
305	0	microtubule-interacting protein that associates with traf3; interleukin 13 receptor alpha 1-binding protein-1. [refseq;acc:nm_015650]	8815	9431	1.06988
	1	mitochondrial ribosomal protein l2. [refseq;acc:nm_015950]	266.986	242.339	1.1017
306	0	williams-beuren syndrome chromosome region 14 protein (ws basic-helix- loop-helix leucine zipper protein) (ws-bhlh) (mlx interactor). [swissprot;acc:q9np71]	5921	5540	1.06877
	1	60s ribosomal protein l14 (cag-isl 7). [swissprot;acc:p50914]	266.673	242.153	1.10126
307	0	ba271b5.1 (similar to ribosomal protein s7). [sptrembl;acc:q9h1s9]	1021	1091	1.06856
	1	serine racemase (ec 5.1.1.-). [swissprot;acc:q9gzt4]	266.673	242.153	1.10126
308	0	intersectin 1 (sh3 domain-containing protein 1a) (sh3p17). [swissprot;acc:q15811]	12191.8	11414.1	1.06814
	1	60s ribosomal protein l34. [swissprot;acc:p49207]	266.673	242.153	1.10126
309	0	lipopolysaccharide-binding protein precursor (lbp). [swissprot;acc:p18428]	14572	13651	1.06747
	1	protein transport protein sec61 alpha subunit isoform 2 (sec61 alpha- 2). [swissprot;acc:q9y2r3]	266.673	242.153	1.10126
310	0	glycine cleavage system h protein, mitochondrial precursor. [swissprot;acc:p23434]	8741.55	9328.78	1.06718
	1	protein transport protein sec61 alpha subunit isoform 1 (sec61 alpha- 1). [swissprot;acc:p38378]	266.673	242.153	1.10126
311	0	60s ribosomal protein l23 (l17). [swissprot;acc:p23131]	9622.45	10253.5	1.06558
	1	protein translation factor sui1 homolog gc20. [swissprot;acc:o60739]	267.151	242.627	1.10108
312	0	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-5 like subunit. [swissprot;acc:q9y3k8]	12731.1	11959.8	1.06449
	1	60s ribosomal protein l3-like. [swissprot;acc:q92901]	266.663	242.195	1.10103
313	0	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-4 subunit. [swissprot;acc:p50150]	12698.9	11935.6	1.06395
	1	ribonucleotide reductase m2 b (tp53 inducible); p53-inducible ribonucleotide reductase small subunit 2 homolog. [refseq;acc:nm_015713]	211.207	232.473	1.10069
314	0	clathrin heavy chain 2 (clh-22). [swissprot;acc:p53675]	10957.5	10301.4	1.06369
	1	methionine aminopeptidase 1 (ec 3.4.11.18) (metap 1) (map 1) (peptidase m 1). [swissprot;acc:p53582]	268.604	244.126	1.10027
315	0	ribonucleoside-diphosphate reductase m1 chain (ec 1.17.4.1) (ribonucleotide reductase large chain). [swissprot;acc:p23921]	12887.6	12121.6	1.06319
	1	methionine aminopeptidase 2 (ec 3.4.11.18) (metap 2) (peptidase m 2) (initiation factor 2 associated 67 kda glycoprotein) (p67) (p67eif2). [swissprot;acc:p50579]	268.604	244.126	1.10027
316	0	dj718p11.1.2 (novel class ii aminotransferase similar to serine palmotyltransferase (isoform 2)) (fragment). [sptrembl;acc:q9ugb5]	11444	10768.5	1.06273
	1	protein translation factor sui1 homolog (sui1iso1). [swissprot;acc:p41567]	267.017	242.694	1.10022
317	0	protein transport protein sec24c (sec24-related protein c). [swissprot;acc:p53992]	18778	19939	1.06183
	1	splicing factor 3b subunit 3 (spliceosome associated protein 130) (sap 130) (sf3b130) (pre-mrna splicing factor sf3b 130 kda subunit). [swissprot;acc:q15393]	204.044	224.445	1.09998
318	0	ubiquitous tropomodulin (u-tmod) (tropomodulin 3). [swissprot;acc:q9nyl9]	9465.32	8918.54	1.06131
	1	mitochondrial 60s ribosomal protein l3 (l3mt). [swissprot;acc:p09001]	266.18	242.011	1.09987
319	0	sorting nexin 9 (sh3 and px domain-containing protein 1) (sdp1 protein). [swissprot;acc:q9y5x1]	9465.32	8918.54	1.06131
	1	60s ribosomal protein l19. [swissprot;acc:p14118]	264.729	240.73	1.09969
320	0	adp-ribosylation factor 3. [swissprot;acc:p16587]	10958.2	11627.8	1.0611
	1	epithelial-cadherin precursor (e-cadherin) (uvomorulin) (cadherin-1) (cam 120/80). [swissprot;acc:p12830]	265.96	241.892	1.0995
321	0	adenine phosphoribosyltransferase (ec 2.4.2.7) (aprt). [swissprot;acc:p07741]	10989.9	11634.4	1.05864
	1	c367g8.3 (novel protein similar to rpl23a (60s ribosomal protein l23a)) (60s ribosomal protein l23a like). [sptrembl;acc:q9br02]	265.959	241.892	1.09949
322	0	estradiol 17 beta-dehydrogenase 1 (ec 1.1.1.62) (17-beta-hsd 1) (placental 17-beta-hydroxysteroid dehydrogenase) (20 alpha- hydroxysteroid dehydrogenase) (20-alpha-hsd) (e2dh). [swissprot;acc:p14061]	10989.9	11634.4	1.05864
	1	deoxyribonuclease ii beta isoform 1 precursor; deoxyribonuclease ii beta; endonuclease dlad. [refseq;acc:nm_021233]	78.8995	86.7483	1.09948
323	0	ras-related c3 botulinum toxin substrate 1 (p21-rac1) (ras-like protein tc25). [swissprot;acc:p15154]	16427.3	17387.1	1.05843
	1	60s ribosomal protein l23a. [swissprot;acc:p29316]	265.945	241.884	1.09947
324	0	ras-related c3 botulinum toxin substrate 3 (p21-rac3). [swissprot;acc:o14658]	16427.3	17387.1	1.05843
	1	40s ribosomal protein s23. [swissprot;acc:p39028]	268.195	243.944	1.09941
325	0	mstp028 protein. [refseq;acc:nm_031954]	7528.21	7965.66	1.05811
	1	28s ribosomal protein s12, mitochondrial precursor (mpr-s12) (mt- rps12). [swissprot;acc:o15235]	268.195	243.944	1.09941

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.