MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Filtered	Value Type	green	Rank	Gene	description	Network Comparison Type	network_comparison	Interaction Map	red

Results: HTML CSV LaTeX

Showing element 451 to 500 of 77072 in total

Filtered  : 0
Value Type  : Measured

green	Rank	description	Network Comparison Type	network_comparison	Interaction Map	red
206.5	434	testis-specific protein tpx-1 precursor (cysteine-rich secretory protein-2) (crisp-2). [swissprot;acc:p16562]	Divided	1.02736	High confidence	201
	459		Subtracted	5.5
210	117	helicase/primase complex protein. [refseq;acc:nm_138336]	Divided	1.35238	Low confidence	284
	504		Subtracted	74
219.891	392	60s ribosomal protein l14 (cag-isl 7). [swissprot;acc:p50914]	Divided	1.04238	High confidence	229.211
	452		Subtracted	9.32
221.565	469	transcription factor btf3 homolog 3. [swissprot;acc:q13892]	Divided	1.00822		219.759
	490		Subtracted	1.806
224.096	94	myosin vi. [swissprot;acc:q9um54]	Divided	1.54338		345.865
	95				Low confidence
	259		Subtracted	121.769	High confidence
	395				Low confidence
226.797	399	similar to lysozyme c-1 (1,4-beta-n-acylmuramidase c, ec 3.2.1.17). [refseq;acc:nm_032517]	Divided	1.10398		250.379
	723		Subtracted	23.582
226.81	410	glycerol kinase, testis specific 2 (ec 2.7.1.30) (atp:glycerol 3- phosphotransferase) (glycerokinase) (gk). [swissprot;acc:q14410]	Divided	1.03704	High confidence	218.71
	456		Subtracted	8.1
227.143	408	glycerol kinase, testis specific 1 (ec 2.7.1.30) (atp:glycerol 3- phosphotransferase) (glycerokinase) (gk). [swissprot;acc:q14409]	Divided	1.03704		219.031
	455		Subtracted	8.112
227.308	409	glycerol kinase (ec 2.7.1.30) (atp:glycerol 3-phosphotransferase) (glycerokinase) (gk). [swissprot;acc:p32189]	Divided	1.03704		219.19
	454		Subtracted	8.118
234.276	94	poly (adp-ribose) glycohydrolase. [refseq;acc:nm_003631]	Divided	1.54599	Low confidence	362.189
	379		Subtracted	127.913
241.74	120	proactivator polypeptide precursor [contains: saposin a (protein a); saposin b (sphingolipid activator protein 1) (sap-1) (cerebroside sulfate activator) (csact) (dispersin) (sulfatide/gm1 activator); saposin c (co-beta-glucosidase) (a1 activator) (glucosylceramidase activator) (sphingolipid activator protein 2) (sap-2); saposin d (protein c) (component c)]. [swissprot;acc:p07602]	Divided	1.3378		180.7
	547		Subtracted	61.04
249.857	487	ras-related c3 botulinum toxin substrate 1 (p21-rac1) (ras-like protein tc25). [swissprot;acc:p15154]	Divided	1.00225	High confidence	250.419
	488	ras-related c3 botulinum toxin substrate 3 (p21-rac3). [swissprot;acc:o14658]
	492	ras-related c3 botulinum toxin substrate 1 (p21-rac1) (ras-like protein tc25). [swissprot;acc:p15154]	Subtracted	0.562
	493	ras-related c3 botulinum toxin substrate 3 (p21-rac3). [swissprot;acc:o14658]
268.468	572	transcription factor bteb4 (basic transcription element binding- protein 4) (bte-binding protein 4) (krueppel-like factor 16) (novel sp1-like zinc finger transcription factor 2) (transcription factor nslp2). [swissprot;acc:q9bxk1]	Divided	1.04582	Low confidence	280.768
	781		Subtracted	12.3
277.003	168	transcription factor dp-1 (e2f dimerization partner 1) (drtf1- polypeptide-1) (drtf1). [swissprot;acc:q14186]	Divided	1.23006		340.73
	542		Subtracted	63.727
279.24	59	f-actin capping protein alpha-2 subunit (capz alpha-2). [swissprot;acc:p47755]	Divided	1.85328	High confidence	150.673
	246		Subtracted	128.567
290.667	103	transketolase-like 1 (ec 2.2.1.1) (transketolase 2) (tk 2) (transketolase related protein). [swissprot;acc:p51854]	Divided	1.47298		197.333
	283		Subtracted	93.334
299.876	84	sedlin. [swissprot;acc:o14582]	Divided	1.64861	Low confidence	181.896
	402		Subtracted	117.98
305.886	70	synbindin (trs23 homolog) (hematopoietic stem/progenitor cell protein 172) (hspc172) (ptd009) (cgi-104). [swissprot;acc:q9y296]	Divided	1.82368		167.73
	355		Subtracted	138.156
306.727	183	blood group rh(d) polypeptide (rhesus d antigen) (rhxiii) (rh polypeptide 2) (rhpii). [swissprot;acc:q02161]	Divided	1.22281	High confidence	375.07
	184	blood group rh(ce) polypeptide (rhesus c/e antigens) (rh30a) (rhixb) (rh polypeptide 1) (rhpi). [swissprot;acc:p18577]
	326	blood group rh(d) polypeptide (rhesus d antigen) (rhxiii) (rh polypeptide 2) (rhpii). [swissprot;acc:q02161]	Subtracted	68.343
	327	blood group rh(ce) polypeptide (rhesus c/e antigens) (rh30a) (rhixb) (rh polypeptide 1) (rhpi). [swissprot;acc:p18577]
306.933	185		Divided	1.22281		375.322
	325		Subtracted	68.389
315.505	59	nadph oxidase, ef hand calcium-binding domain 5. [refseq;acc:nm_024505]	Divided	2.14473	Low confidence	147.107
	309		Subtracted	168.398
315.567	60	nadph oxidase homolog 1 (nox-1) (noh-1) (nadh/nadph mitogenic oxidase subunit p65-mox) (mitogenic oxidase 1) (mox1). [swissprot;acc:q9y5s8]	Divided	2.14463		147.143
	308		Subtracted	168.424

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.