MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	description	Value Type	Network Comparison Type	Filtered	network_comparison	Interaction Map	green	red

Results: HTML CSV LaTeX

Showing element 1 to 50 of 33156 in total

Network Comparison Type  : Divided
Filtered  : 1

Rank	description	Value Type	network_comparison	Interaction Map	green	red
1	carboxypeptidase d precursor (ec 3.4.17.-) (gp180). [swissprot;acc:o75976]	Ranked	2	Low confidence	32	16
	lysosome-associated membrane glycoprotein 1 precursor (lamp-1) (cd107a antigen). [swissprot;acc:p11279]	Measured	4.4149		543.5	2399.5
		Squared	19.4914		69.9153	1362.75
		Rooted	2.10117		23.3131	48.9847
	putative glialblastoma cell differentiation-related; putative glialblastoma cell differentiation-related protein. [refseq;acc:nm_016172]	Ranked	2.4	High confidence	24	10
	rad50-interacting protein 1. [refseq;acc:nm_021930]	Measured	5.31521		2394.5	450.5
		Squared	28.2513		1357.07	48.0356
		Rooted	2.30547		48.9336	21.225
2	cell division protein kinase 4 (ec 2.7.1.37) (cyclin-dependent kinase 4) (psk-j3). [swissprot;acc:p11802]	Measured	4.4149	Low confidence	543.5	2399.5
		Squared	19.4914		69.9153	1362.75
		Rooted	2.10117		23.3131	48.9847
	lysosome-associated membrane glycoprotein 1 precursor (lamp-1) (cd107a antigen). [swissprot;acc:p11279]	Ranked	1.47982		330	223
	mannosyl-oligosaccharide 1,2-alpha-mannosidase ib (ec 3.2.1.113) (processing alpha-1,2-mannosidase ib) (alpha-1,2-mannosidase ib) (mannosidase alpha class 1a member 2). [swissprot;acc:o60476]		1.86667	High confidence	28	15
	rho-related btb domain-containing protein 2 (deleted in breast cancer 2 gene protein) (p83). [swissprot;acc:q9byz6]	Measured	5.31521		2394.5	450.5
		Squared	28.2513		1357.07	48.0356
		Rooted	2.30547		48.9336	21.225
3	cell division protein kinase 4 (ec 2.7.1.37) (cyclin-dependent kinase 4) (psk-j3). [swissprot;acc:p11802]	Ranked	1.47982	Low confidence	330	223
	cell division protein kinase 6 (ec 2.7.1.37) (serine/threonine protein kinase plstire). [swissprot;acc:q00534]	Measured	4.4149		543.5	2399.5
		Squared	19.4914		69.9153	1362.75
		Rooted	2.10117		23.3131	48.9847
	cytohesin 1 (sec7 homolog b2-1). [swissprot;acc:q15438]	Ranked	1.86667	High confidence	28	15
	homeobox protein hlx1 (homeobox protein hb24). [swissprot;acc:q14774]	Measured	3.71868		698.5	2597.5
		Squared	13.8285		115.48	1596.92
		Rooted	1.92839		26.4292	50.9657
4	cell division protein kinase 6 (ec 2.7.1.37) (serine/threonine protein kinase plstire). [swissprot;acc:q00534]	Ranked	1.47982	Low confidence	330	223
	cytohesin 2 (arf nucleotide-binding site opener) (arno protein) (arf exchange factor). [swissprot;acc:q99418]		1.86667	High confidence	28	15
	hbs1-like. [refseq;acc:nm_006620]	Measured	3.71868		698.5	2597.5
		Squared	13.8285		115.48	1596.92
		Rooted	1.92839		26.4292	50.9657
	lysosome-associated membrane glycoprotein 2 precursor (lamp-2) (cd107b antigen). [swissprot;acc:p13473]	Measured	4.4149	Low confidence	543.5	2399.5
		Squared	19.4914		69.9153	1362.75
		Rooted	2.10117		23.3131	48.9847
5	cytohesin 4. [swissprot;acc:q9uia0]	Ranked	1.86667	High confidence	28	15
	junctophilin 3 (junctophilin type 3) (jp-3). [swissprot;acc:q8wxh2]	Measured	3.39764		339.5	1153.5
		Squared	11.544		27.2805	314.926
		Rooted	1.84327		18.4255	33.9632
	lysosome-associated membrane glycoprotein 2 precursor (lamp-2) (cd107b antigen). [swissprot;acc:p13473]	Ranked	1.47982	Low confidence	330	223
	oxysterol binding protein-related protein 6 (osbp-related protein 6) (orp-6). [swissprot;acc:q9bzf3]	Measured	2.86965		2113.5	736.5
		Squared	8.23493		1057.25	128.386
		Rooted	1.69401		45.9728	27.1385
6	cytohesin 3 (arf nucleotide-binding site opener 3) (arno3 protein) (general receptor of phosphoinositides 1) (grp1). [swissprot;acc:o43739]	Ranked	1.86667	High confidence	28	15
	junctophilin 2 (junctophilin type 2) (jp-2). [swissprot;acc:q9br39]	Measured	3.39764		339.5	1153.5
		Squared	11.544		27.2805	314.926
		Rooted	1.84327		18.4255	33.9632
	oxysterol binding protein-related protein 3 (osbp-related protein 3) (orp-3). [swissprot;acc:q9h4l5]	Measured	2.86965	Low confidence	2113.5	736.5
		Squared	8.23493		1057.25	128.386
		Rooted	1.69401		45.9728	27.1385
	oxysterol binding protein-related protein 6 (osbp-related protein 6) (orp-6). [swissprot;acc:q9bzf3]	Ranked	1.325		240	318
7	homeobox protein hlx1 (homeobox protein hb24). [swissprot;acc:q14774]		1.49767	High confidence	322	215
	oxysterol binding protein-related protein 3 (osbp-related protein 3) (orp-3). [swissprot;acc:q9h4l5]		1.325	Low confidence	240	318

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.