MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	description	Value Type	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 525 to 574 of 6456 in total

Value Type  : Ranked
Interaction Map  : High confidence
Filtered  : 1

Rank	description	Network Comparison Type	red	green	network_comparison
263	heparan sulfate d-glucosaminyl 3-o-sulfotransferase 2; heparin-glucosamine 3-o-sulfotransferase. [refseq;acc:nm_006043]	Divided	219.421	196.978	1.11394
	protein 1-4 (atp binding protein associated with cell differentiation). [swissprot;acc:o14530]	Subtracted	242.14	265.696	23.556
264	60s ribosomal protein l10a (csa-19). [swissprot;acc:p53025]		243.24	266.796
	mrna decapping enzyme; histidine triad protein member 5; heat shock-like protein 1. [refseq;acc:nm_014026]	Divided	219.421	196.978	1.11394
265	60s ribosomal protein l9. [swissprot;acc:p32969]	Subtracted	240.243	263.798	23.555
	splicing factor 3b subunit 1 (spliceosome associated protein 155) (sap 155) (sf3b155) (pre-mrna splicing factor sf3b 155 kda subunit). [swissprot;acc:o75533]	Divided	225.217	202.459	1.11241
266	ribosomal protein l10-like protein. [refseq;acc:nm_080746]	Subtracted	243.12	266.662	23.542
	transcriptional co-repressor sin3a; transcriptional regulator, sin3a (yeast). [refseq;acc:nm_015477]	Divided	241.07	267.88	1.11121
267	60s ribosomal protein l10 (qm protein) (tumor suppressor qm) (laminin receptor homolog). [swissprot;acc:p27635]	Subtracted	243.12	266.661	23.541
	density-regulated protein (drp) (drp1 protein) (smooth muscle cell associated protein-3) (smap-3). [swissprot;acc:o43583]	Divided	241.07	267.88	1.11121
268	eukaryotic translation initiation factor 5 (eif-5). [swissprot;acc:p55010]		271.016	244.167	1.10996
	protein arginine n-methyltransferase 3 (ec 2.1.1.-) (fragment). [swissprot;acc:o60678]	Subtracted	241.625	265.136	23.511
269	40s ribosomal protein s2 (s4) (llrep3 protein). [swissprot;acc:p15880]
	cholinephosphate cytidylyltransferase a (ec 2.7.7.15) (phosphorylcholine transferase a) (ctp:phosphocholine cytidylyltransferase a) (ct a) (cct a) (cct-alpha). [swissprot;acc:p49585]	Divided	241.373	267.352	1.10763
270	40s ribosomal protein s3. [swissprot;acc:p23396]	Subtracted	241.612	265.119	23.507
	fad synthetase. [refseq;acc:nm_025207]	Divided	241.373	267.352	1.10763
271	bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthethase 2 (paps synthethase 2) (papss 2) (sulfurylase kinase 2) (sk2) (sk 2) [includes: sulfate adenylyltransferase (ec 2.7.7.4) (sulfate adenylate transferase) (sat) (atp-sulfurylase); adenylylsulfate kinase (ec 2.7.1.25) (adenylylsulfate 3'-phosphotransferase) (aps kinase) (adenosine-5'-phosphosulfate 3'-phosphotransferase) (3'- phosphoadenosine-5'-phosphosulfate synthetase)]. [swissprot;acc:o95340]
	protein transport protein sec61 gamma subunit. [swissprot;acc:p38384]	Subtracted	243.072	266.559	23.487
272	ligatin (hepatocellular carcinoma-associated antigen 56). [swissprot;acc:p41214]	Divided	241.373	267.352	1.10763
	mitochondrial ribosomal protein l17; lyst-interacting protein lip2. [refseq;acc:nm_022061]	Subtracted	242.83	266.248	23.418
273	bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthethase 1 (paps synthethase 1) (papss 1) (sulfurylase kinase 1) (sk1) (sk 1) [includes: sulfate adenylyltransferase (ec 2.7.7.4) (sulfate adenylate transferase) (sat) (atp-sulfurylase); adenylylsulfate kinase (ec 2.7.1.25) (adenylylsulfate 3'-phosphotransferase) (aps kinase) (adenosine-5'-phosphosulfate 3'-phosphotransferase) (3'- phosphoadenosine-5'-phosphosulfate synthetase)]. [swissprot;acc:o43252]	Divided	241.373	267.352	1.10763
	dna-directed rna polymerase ii 140 kda polypeptide (ec 2.7.7.6) (rna polymerase ii subunit 2) (rpb2). [swissprot;acc:p30876]	Subtracted	243.208	266.617	23.409
274	60s ribosomal protein l36, mitochondrial precursor (l36mt) (brca1- interacting protein 1). [swissprot;acc:q9p0j6]		242.744	266.07	23.326
	nadph-cytochrome p450 reductase (ec 1.6.2.4) (cpr) (p450r). [swissprot;acc:p16435]	Divided	241.373	267.352	1.10763
275	40s ribosomal protein s5. [swissprot;acc:p46782]	Subtracted	242.473	265.756	23.283
	cholinephosphate cytidylyltransferase b (ec 2.7.7.15) (phosphorylcholine transferase b) (ctp:phosphocholine cytidylyltransferase b) (ct b) (cct b) (cct-beta). [swissprot;acc:q9y5k3]	Divided	241.373	267.352	1.10763
276	60s ribosomal protein l32. [swissprot;acc:p02433]		241.13	266.969	1.10716
	atp-dependent rna helicase ddx24 (dead-box protein 24). [swissprot;acc:q9gzr7]	Subtracted	258.437	235.183	23.254
277	40s ribosomal protein s29. [swissprot;acc:p30054]	Divided	241.849	267.642	1.10665
	60s ribosomal protein l4 (l1). [swissprot;acc:p36578]	Subtracted	239.277	262.434	23.157
278	40s ribosomal protein s11. [swissprot;acc:p04643]	Divided	241.399	267.088	1.10642
	myelin gene expression factor 2. [refseq;acc:nm_016132]	Subtracted	235.383	258.476	23.093
279	histone acetyltransferase type b subunit 2 (retinoblastoma binding protein p46) (retinoblastoma-binding protein 7) (rbbp-7). [swissprot;acc:q16576]	Divided	252.644	228.42	1.10605
	trna pseudouridine synthase a (ec 4.2.1.70) (pseudouridylate synthase i) (pseudouridine synthase i) (uracil hydrolyase). [swissprot;acc:q9y606]	Subtracted	242.66	265.715	23.055
280	metastasis-associated protein mta1. [swissprot;acc:q13330]	Divided	252.512	228.356	1.10578
	transcription factor dp-2 (e2f dimerization partner 2). [swissprot;acc:q14188]	Subtracted	267.208	244.168	23.04
281	60s ribosomal protein l12, mitochondrial precursor (l12mt) (5c5-2). [swissprot;acc:p52815]		242.159	265.104	22.945
	60s ribosomal protein l17 (l23). [swissprot;acc:p18621]	Divided	241.808	267.335	1.10557
282	chromatin assembly factor 1 subunit c (caf-1 subunit c) (chromatin assembly factor i p48 subunit) (caf-i 48 kda subunit) (caf-ip48) (retinoblastoma binding protein p48) (retinoblastoma-binding protein 4) (rbbp-4) (msi1 protein homolog). [swissprot;acc:q09028]		252.39	228.297	1.10553
	nudix (nucleoside diphosphate linked moiety x)-type motif 12. [refseq;acc:nm_031438]	Subtracted	242.159	265.104	22.945
283	60s ribosomal protein l11, mitochondrial precursor (l11mt) (cgi-113). [swissprot;acc:q9y3b7]		242.37	265.255	22.885
	60s ribosomal protein l11. [swissprot;acc:p39026]	Divided	241.828	267.346	1.10552
284	crk-associated substrate (p130cas) (breast cancer anti-estrogen resistance 1 protein). [swissprot;acc:p56945]		224.657	203.235	1.10541
	dna-directed rna polymerase iii largest subunit (ec 2.7.7.6) (rpc155) (rpc1). [swissprot;acc:o14802]	Subtracted	242.686	265.516	22.83
285	dna-directed rna polymerase i largest subunit (ec 2.7.7.6) (rna polymerase i 194 kda subunit) (rpa194). [swissprot;acc:o95602]		242.691	265.481	22.79
	t-complex protein 1, delta subunit (tcp-1-delta) (cct-delta) (stimulator of tar rna binding). [swissprot;acc:p50991]	Divided	224.647	203.242	1.10532
286	60s ribosomal protein l30. [swissprot;acc:p04645]	Subtracted	242.593	265.365	22.772
	enhancer of filamentation 1 (hef1) (crk-associated substrate-related protein) (cas-l) (casl) (pp105) (neural precursor cell expressed developmentally down-regulated 9). [swissprot;acc:q14511]	Divided	224.633	203.251	1.1052
287	40s ribosomal protein s4, y isoform 2. [swissprot;acc:q8td47]		240.758	266.079	1.10517
	splicing factor 3b subunit 1 (spliceosome associated protein 155) (sap 155) (sf3b155) (pre-mrna splicing factor sf3b 155 kda subunit). [swissprot;acc:o75533]	Subtracted	225.217	202.459	22.758

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.