MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	description	Value Type	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 2430 to 2479 of 6456 in total

Value Type  : Ranked
Interaction Map  : High confidence
Filtered  : 1

Rank	description	Network Comparison Type	red	green	network_comparison
1215	peptidyl-prolyl cis-trans isomerase e (ec 5.2.1.8) (ppiase e) (rotamase e) (cyclophilin e) (cyclophilin 33). [swissprot;acc:q9unp9]	Subtracted	174.387	179.697	5.31
1216	coatomer zeta-2 subunit (zeta-2 coat protein) (zeta-2 cop). [swissprot;acc:q9p299]
	retinoic acid induced 17; pias-like protein hzimp10. [refseq;acc:nm_020338]	Divided	218.269	212.918	1.02513
1217	glutaminyl-trna synthase (glutamine-hydrolyzing)-like 1. [refseq;acc:nm_018292]		211.959	217.258	1.025
	hyaluronan synthase 2 (ec 2.4.1.212) (hyaluronate synthase 2) (hyaluronic acid synthase 2) (ha synthase 2). [swissprot;acc:q92819]	Subtracted	221.093	226.399	5.306
1218	fatty-acid amide hydrolase (ec 3.1.-.-) (oleamide hydrolase) (anandamide amidohydrolase). [swissprot;acc:o00519]	Divided	211.959	217.258	1.025
	hyaluronan synthase 1 (ec 2.4.1.212) (hyaluronate synthase 1) (hyaluronic acid synthase 1) (ha synthase 1) (huhas1). [swissprot;acc:q92839]	Subtracted	221.093	226.399	5.306
1219	coactosin-like protein. [swissprot;acc:q14019]	Divided	211.959	217.258	1.025
	hyaluronan synthase 3 (ec 2.4.1.212) (hyaluronate synthase 3) (hyaluronic acid synthase 3) (ha synthase 3). [swissprot;acc:o00219]	Subtracted	221.093	226.399	5.306
1220	glutaminyl-trna synthase (glutamine-hydrolyzing)-like 1. [refseq;acc:nm_018292]		211.959	217.258	5.299
	uracil-dna glycosylase, mitochondrial precursor (ec 3.2.2.-) (udg). [swissprot;acc:p13051]	Divided			1.025
1221	fatty-acid amide hydrolase (ec 3.1.-.-) (oleamide hydrolase) (anandamide amidohydrolase). [swissprot;acc:o00519]	Subtracted			5.299
	probable glutamyl-trna(gln) amidotransferase subunit b, mitochondrial precursor (ec 6.3.5.-) (glu-adt subunit b) (cytochrome oxidase assembly factor pet112 homolog). [swissprot;acc:o75879]	Divided			1.025
1222	coactosin-like protein. [swissprot;acc:q14019]	Subtracted			5.299
	tumor protein d53 (hd53) (d52-like 1). [swissprot;acc:q16890]	Divided	206.774	211.936	1.02496
1223	tumor protein d52 (n8 protein). [swissprot;acc:p55327]		206.771	211.926	1.02493
	uracil-dna glycosylase, mitochondrial precursor (ec 3.2.2.-) (udg). [swissprot;acc:p13051]	Subtracted	211.959	217.258	5.299
1224	folylpolyglutamate synthase, mitochondrial precursor (ec 6.3.2.17) (folylpoly-gamma-glutamate synthetase) (fpgs). [swissprot;acc:q05932]	Divided	225.906	231.524	1.02487
	probable glutamyl-trna(gln) amidotransferase subunit b, mitochondrial precursor (ec 6.3.5.-) (glu-adt subunit b) (cytochrome oxidase assembly factor pet112 homolog). [swissprot;acc:o75879]	Subtracted	211.959	217.258	5.299
1225	interleukin-4 induced protein 1 precursor (fig-1 protein). [swissprot;acc:q96rq9]		219.55	214.288	5.262
	ubiquitin-conjugating enzyme e2 e1 (ec 6.3.2.19) (ubiquitin-protein ligase e1) (ubiquitin carrier protein e1) (ubch6). [swissprot;acc:p51965]	Divided	166.846	170.989	1.02483
1226	adrenodoxin, mitochondrial precursor (adrenal ferredoxin) (hepatoredoxin) (ferredoxin 1). [swissprot;acc:p10109]	Subtracted	191.139	185.882	5.257
	ubiquitin-conjugating enzyme e2e 3; ubiquitin carrier protein; ubiquitin-protein ligase. [refseq;acc:nm_006357]	Divided	166.846	170.989	1.02483
1227	glutamate--cysteine ligase regulatory subunit (ec 6.3.2.2) (gamma- glutamylcysteine synthetase) (gamma-ecs) (gcs light chain) (glutamate--cysteine ligase modifier subunit). [swissprot;acc:p48507]	Subtracted	213.079	218.325	5.246
	pyrroline 5-carboxylate reductase isoform. [refseq;acc:nm_013328]	Divided	172.365	168.219	1.02465
1228	glutamate--cysteine ligase catalytic subunit (ec 6.3.2.2) (gamma- glutamylcysteine synthetase) (gamma-ecs) (gcs heavy chain). [swissprot;acc:p48506]	Subtracted	213.079	218.325	5.246
	glutamate--cysteine ligase regulatory subunit (ec 6.3.2.2) (gamma- glutamylcysteine synthetase) (gamma-ecs) (gcs light chain) (glutamate--cysteine ligase modifier subunit). [swissprot;acc:p48507]	Divided			1.02462
1229	glutamate--cysteine ligase catalytic subunit (ec 6.3.2.2) (gamma- glutamylcysteine synthetase) (gamma-ecs) (gcs heavy chain). [swissprot;acc:p48506]
	integral membrane protein cii-3b. [sptrembl;acc:o75609]	Subtracted	207.646	212.891	5.245
1230	interleukin-4 induced protein 1 precursor (fig-1 protein). [swissprot;acc:q96rq9]	Divided	219.55	214.288	1.02456
	succinate dehydrogenase cytochrome b560 subunit, mitochondrial precursor (integral membrane protein cii-3) (qps1) (qps-1) (succinate dehydrogenase complex subunit c) (succinate-ubiquinone oxidoreductase cytochrome b large subunit) (cybl). [swissprot;acc:q99643]	Subtracted	207.644	212.888	5.244
1231	putative phosphoglycerate mutase 3 (ec 5.4.2.1) (ec 5.4.2.4) (ec 3.1.3.13). [swissprot;acc:q8n0y7]	Divided	212.724	207.637	1.0245
	succinate dehydrogenase [ubiquinone] iron-sulfur protein, mitochondrial precursor (ec 1.3.5.1) (ip) (iron-sulfur subunit of complex ii). [swissprot;acc:p21912]	Subtracted	207.931	213.175	5.244
1232	alpha-1-acid glycoprotein 2 precursor (agp 2) (orosomucoid 2) (omd 2). [swissprot;acc:p19652]		209.649	204.406	5.243
	pyrroline-5-carboxylate reductase (ec 1.5.1.2) (p5cr) (p5c reductase). [swissprot;acc:p32322]	Divided	172.543	168.417	1.0245
1233	phosphoglycerate mutase 1 (ec 5.4.2.1) (ec 5.4.2.4) (ec 3.1.3.13) (phosphoglycerate mutase isozyme b) (pgam-b) (bpg-dependent pgam 1). [swissprot;acc:p18669]		212.724	207.637
	septin 1 (larp) (serologically defined breast cancer antigen ny-br- 24). [swissprot;acc:q8wyj6]	Subtracted	142.077	136.846	5.231
1234	phosphoglycerate mutase 2 (ec 5.4.2.1) (ec 5.4.2.4) (ec 3.1.3.13) (phosphoglycerate mutase isozyme m) (pgam-m) (bpg-dependent pgam 2) (muscle-specific phosphoglycerate mutase). [swissprot;acc:p15259]	Divided	212.724	207.637	1.0245
	ubiquitin. [swissprot;acc:p02248]	Subtracted	209.6	204.372	5.228
1235	coatomer alpha subunit (alpha-coat protein) (alpha-cop) (hepcop) (hep-cop) [contains: xenin (xenopsin-related peptide); proxenin]. [swissprot;acc:p53621]		177.432	182.647	5.215
	keratin associated protein 9-4; keratin associated protein 9.4. [refseq;acc:nm_033191]	Divided	219.356	224.723	1.02447
1236	keratin associated protein 4-10; keratin associated protein 4.10. [refseq;acc:nm_033060]		219.354	224.699	1.02437
	prefoldin subunit 3 (von hippel-lindau binding protein 1) (vhl binding protein-1) (vbp-1) (hibbj46). [swissprot;acc:q15765]	Subtracted	226.439	221.26	5.179
1237	keratin associated protein 4-2; keratin associated protein 4.2. [refseq;acc:nm_033062]	Divided	219.354	224.699	1.02437
	prefoldin subunit 2 (hspc231). [swissprot;acc:q9uhv9]	Subtracted	226.439	221.26	5.179
1238	keratin associated protein 4.3 (fragment). [sptrembl;acc:q9byr4]	Divided	219.354	224.699	1.02437
	uxt protein (ubiquitously expressed transcript protein) (hspc024). [swissprot;acc:q9ubk9]	Subtracted	226.439	221.26	5.179
1239	keratin associated protein 2-4; keratin associated protein 2.4. [refseq;acc:nm_033184]	Divided	219.354	224.699	1.02437
	signal transducer and activator of transcription 4. [swissprot;acc:q14765]	Subtracted	222.573	227.751	5.178
1240	keratin associated protein 4-14; keratin associated protein 4.14. [refseq;acc:nm_033059]	Divided	219.354	224.7	1.02437

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.