MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	Value Type	description	Network Comparison Type	Filtered	red	Interaction Map	network_comparison	green

Results: HTML CSV LaTeX

Showing element 1 to 50 of 38536 in total

Network Comparison Type  : Divided

Rank	Value Type	description	Filtered	red	Interaction Map	network_comparison	green
1	Measured	lysosome-associated membrane glycoprotein 1 precursor (lamp-1) (cd107a antigen). [swissprot;acc:p11279]	1	2399.5	Low confidence	4.4149	543.5
		mitochondrial 28s ribosomal protein s32 (s32mt) (mrp-s32) (ptd007) (hspc204). [swissprot;acc:q9y6g3]	0	364	High confidence	36400000	0.00001
					Low confidence
		rad50-interacting protein 1. [refseq;acc:nm_021930]	1	450.5	High confidence	5.31521	2394.5
	Ranked	adp-ribosylation factor gtpase-activating protein 3 (arf gap 3). [swissprot;acc:q9np61]	0	4294		3.70633	15915
		carboxypeptidase d precursor (ec 3.4.17.-) (gp180). [swissprot;acc:o75976]	1	16	Low confidence	2	32
		mln 64 protein (star-related lipid transfer protein 3) (stard3) (start domain-containing protein 3) (cab1 protein). [swissprot;acc:q14849]	0	5865		2.55362	14977
		putative glialblastoma cell differentiation-related; putative glialblastoma cell differentiation-related protein. [refseq;acc:nm_016172]	1	10	High confidence	2.4	24
	Squared	cab2. [refseq;acc:nm_033419]	0	0.00001		716592	7.16592
		homeobox protein hox-c4 (hox-3e) (cp19). [swissprot;acc:p09017]			Low confidence	187479	1.87479
		lysosome-associated membrane glycoprotein 1 precursor (lamp-1) (cd107a antigen). [swissprot;acc:p11279]	1	1362.75		19.4914	69.9153
		rad50-interacting protein 1. [refseq;acc:nm_021930]		48.0356	High confidence	28.2513	1357.07
	Rooted	lysosome-associated membrane glycoprotein 1 precursor (lamp-1) (cd107a antigen). [swissprot;acc:p11279]		48.9847	Low confidence	2.10117	23.3131
		mitochondrial 28s ribosomal protein s32 (s32mt) (mrp-s32) (ptd007) (hspc204). [swissprot;acc:q9y6g3]	0	19.0788	High confidence	1907880	0.00001
					Low confidence
		rad50-interacting protein 1. [refseq;acc:nm_021930]	1	21.225	High confidence	2.30547	48.9336
2	Measured	cab2. [refseq;acc:nm_033419]	0	0.00001		17400000	174
		cell division protein kinase 4 (ec 2.7.1.37) (cyclin-dependent kinase 4) (psk-j3). [swissprot;acc:p11802]	1	2399.5	Low confidence	4.4149	543.5
		homeobox protein hox-c4 (hox-3e) (cp19). [swissprot;acc:p09017]	0	0.00001		8900000	89
		rho-related btb domain-containing protein 2 (deleted in breast cancer 2 gene protein) (p83). [swissprot;acc:q9byz6]	1	450.5	High confidence	5.31521	2394.5
	Ranked	lysosome-associated membrane glycoprotein 1 precursor (lamp-1) (cd107a antigen). [swissprot;acc:p11279]		223	Low confidence	1.47982	330
		mannosyl-oligosaccharide 1,2-alpha-mannosidase ib (ec 3.2.1.113) (processing alpha-1,2-mannosidase ib) (alpha-1,2-mannosidase ib) (mannosidase alpha class 1a member 2). [swissprot;acc:o60476]		15	High confidence	1.86667	28
		mitochondrial 28s ribosomal protein s32 (s32mt) (mrp-s32) (ptd007) (hspc204). [swissprot;acc:q9y6g3]	0	8906	Low confidence	2.45711	21883
		mln 64 protein (star-related lipid transfer protein 3) (stard3) (start domain-containing protein 3) (cab1 protein). [swissprot;acc:q14849]		5865	High confidence	2.55362	14977
	Squared	cell division protein kinase 4 (ec 2.7.1.37) (cyclin-dependent kinase 4) (psk-j3). [swissprot;acc:p11802]	1	1362.75	Low confidence	19.4914	69.9153
		homeobox protein hox-c6 (hox-3c) (hho.c8) (cp25). [swissprot;acc:p09630]	0	0.00001		187479	1.87479
		nuclear receptor co-repressor/hdac3 complex subunit tblr1 (tbl1- related protein 1). [swissprot;acc:q9bzk7]		5.61325	High confidence	561325	0.00001
		rho-related btb domain-containing protein 2 (deleted in breast cancer 2 gene protein) (p83). [swissprot;acc:q9byz6]	1	48.0356		28.2513	1357.07
	Rooted	cell division protein kinase 4 (ec 2.7.1.37) (cyclin-dependent kinase 4) (psk-j3). [swissprot;acc:p11802]		48.9847	Low confidence	2.10117	23.3131
		homeobox protein hox-c4 (hox-3e) (cp19). [swissprot;acc:p09017]	0	0.00001		943398	9.43398
		nuclear receptor co-repressor/hdac3 complex subunit tblr1 (tbl1- related protein 1). [swissprot;acc:q9bzk7]		12.4097	High confidence	1240970	0.00001
		rho-related btb domain-containing protein 2 (deleted in breast cancer 2 gene protein) (p83). [swissprot;acc:q9byz6]	1	21.225		2.30547	48.9336
3	Measured	cell division protein kinase 6 (ec 2.7.1.37) (serine/threonine protein kinase plstire). [swissprot;acc:q00534]		2399.5	Low confidence	4.4149	543.5
		homeobox protein hlx1 (homeobox protein hb24). [swissprot;acc:q14774]		2597.5	High confidence	3.71868	698.5
		homeobox protein hox-c6 (hox-3c) (hho.c8) (cp25). [swissprot;acc:p09630]	0	0.00001	Low confidence	8900000	89
		pyridoxine 5'-phosphate oxidase. [refseq;acc:nm_018129]			High confidence	10900000	109
	Ranked	cell division protein kinase 4 (ec 2.7.1.37) (cyclin-dependent kinase 4) (psk-j3). [swissprot;acc:p11802]	1	223	Low confidence	1.47982	330
		cytohesin 1 (sec7 homolog b2-1). [swissprot;acc:q15438]		15	High confidence	1.86667	28
		neurogenic locus notch homolog protein 1 precursor (notch 1) (hn1) (translocation-associated notch protein tan-1). [swissprot;acc:p46531]	0	9607	Low confidence	2.14604	20617
		nif3-like protein 1 (amyotrophic lateral sclerosis 2 chromosomal region candidate gene protein 1) (my018 protein) (mds015). [swissprot;acc:q9gzt8]		4475.84	High confidence	2.47638	11083.9
	Squared	cell division protein kinase 6 (ec 2.7.1.37) (serine/threonine protein kinase plstire). [swissprot;acc:q00534]	1	1362.75	Low confidence	19.4914	69.9153
		homeobox protein hlx1 (homeobox protein hb24). [swissprot;acc:q14774]		1596.92	High confidence	13.8285	115.48
		homeobox protein hox-a4 (hox-1d) (hox-1.4). [swissprot;acc:q00056]	0	0.00001	Low confidence	187479	1.87479
		transducin beta-like 1y protein (transducin-beta-like 1, y-linked). [swissprot;acc:q9bq87]		5.61325	High confidence	561325	0.00001
	Rooted	cell division protein kinase 6 (ec 2.7.1.37) (serine/threonine protein kinase plstire). [swissprot;acc:q00534]	1	48.9847	Low confidence	2.10117	23.3131
		homeobox protein hlx1 (homeobox protein hb24). [swissprot;acc:q14774]		50.9657	High confidence	1.92839	26.4292
		homeobox protein hox-c6 (hox-3c) (hho.c8) (cp25). [swissprot;acc:p09630]	0	0.00001	Low confidence	943398	9.43398
		transducin beta-like 1y protein (transducin-beta-like 1, y-linked). [swissprot;acc:q9bq87]		12.4097	High confidence	1240970	0.00001
4	Measured	hbs1-like. [refseq;acc:nm_006620]	1	2597.5		3.71868	698.5
		homeobox protein hox-a4 (hox-1d) (hox-1.4). [swissprot;acc:q00056]	0	0.00001	Low confidence	8900000	89

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.