MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Gene	Rank	Filtered	description	Value Type	Network Comparison Type	green	Interaction Map	red	network_comparison

Results: HTML CSV LaTeX

Showing element 51 to 100 of 9634 in total

Value Type  : Measured
Network Comparison Type  : Divided

Rank	Filtered	description	green	Interaction Map	red	network_comparison
13	1	cytoplasmic polyadenylation element binding protein 3. [refseq;acc:nm_014912]	1281.5	High confidence	398.5	3.21581
		jumonji domain containing 1; zinc finger protein; testis-specific protein a. [refseq;acc:nm_018433]	2959.19	Low confidence	1927.68	1.5351
14	0	cyclin h (mo15-associated protein) (p37) (p34). [swissprot;acc:p51946]	6.50325	High confidence	130.512	20.0687
		guanine nucleotide-binding protein beta subunit-like protein 1 (g protein beta-subunit like protein 1) (wd40 repeat containing protein deleted in vcfs) (wdvcf protein) (fksg1 protein) (dgcrk3). [swissprot;acc:q9byb4]	59	Low confidence	0.00001	5900000
	1	ras gtpase-activating protein ngap (ras protein activator like 1). [swissprot;acc:q9ujf2]	1281.5	High confidence	398.5	3.21581
		trypsin iii precursor (ec 3.4.21.4) (brain trypsinogen) (mesotrypsinogen) (trypsin iv). [swissprot;acc:p35030]	2998.1	Low confidence	1972.65	1.51983
15	0	lipopolysaccharide-responsive and beige-like anchor protein (cdc4-like protein) (beige-like protein). [swissprot;acc:p50851]	2740.13		485.286	5.64642
		succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial precursor (cybs) (succinate-ubiquinone reductase membrane anchor subunit) (qps2) (cii-4) (succinate dehydrogenase complex subunit d) (succinate-ubiquinone oxidoreductase cytochrome b small subunit). [swissprot;acc:o14521]	156	High confidence	10	15.6
	1	trypsin i precursor (ec 3.4.21.4) (cationic trypsinogen). [swissprot;acc:p07477]	3007.85	Low confidence	1983.91	1.51612
		xpa binding protein 1; mbd2 interactor protein; putative atp(gtp)-binding protein. [refseq;acc:nm_007266]	871	High confidence	2671	3.06659
16	0	protein kinase, lysine deficient 3. [refseq;acc:nm_020922]	704.5	Low confidence	125	5.636
		protein transport protein sec24c (sec24-related protein c). [swissprot;acc:p53992]	15	High confidence	1	15
	1	28s ribosomal protein s17, mitochondrial precursor (mrp-s17) (hspc011). [swissprot;acc:q9y2r5]	28492	Low confidence	21185	1.34491
		protein x 0004. [refseq;acc:nm_016301]	871	High confidence	2671	3.06659
17	0	mln 64 protein (star-related lipid transfer protein 3) (stard3) (start domain-containing protein 3) (cab1 protein). [swissprot;acc:q14849]	58		859	14.8103
		ptd016 protein. [refseq;acc:nm_016125]	158	Low confidence	30	5.26667
	1	dgcr14 protein (digeorge syndrome critical region 14) (es2 protein). [swissprot;acc:q96df8]	1365	High confidence	460	2.96739
		mitochondrial solute carrier protein. [refseq;acc:nm_145305]	28492	Low confidence	21185	1.34491
18	0	60s ribosomal protein l37a. [swissprot;acc:p12751]	26.1599	High confidence	305.45	11.6763
		camp-regulated phosphoprotein 19 (arpp-19) [contains: camp-regulated phosphoprotein 16 (arpp-16)]. [swissprot;acc:p56211]	19	Low confidence	99	5.21053
	1	cyclic-amp-dependent transcription factor atf-3 (activating transcription factor 3). [swissprot;acc:p18847]	7251		5492.04	1.32027
		protein phosphatase 1, regulatory (inhibitor) subunit 14a; 17-kda pkc-potentiated inhibitory protein of pp1. [refseq;acc:nm_033256]	1865.5	High confidence	677.5	2.75351
19	0	25-hydroxyvitamin d-1 alpha hydroxylase, mitochondrial precursor (ec 1.14.-.-) (25-ohd-1 alpha-hydroxylase) (25-hydroxyvitamin d3 1- alpha-hydroxylase) (vd3 1a hydroxylase) (p450c1 alpha) (p450vd1- alpha). [swissprot;acc:o15528]	26.1599		305.45	11.6763
		fatty acid desaturase 1; linoleoyl-coa desaturase (delta-6-desaturase)-like 1; delta-5 desaturase; delta-5 fatty acid desaturase. [refseq;acc:nm_013402]	662	Low confidence	153	4.3268
	1	25-hydroxyvitamin d-1 alpha hydroxylase, mitochondrial precursor (ec 1.14.-.-) (25-ohd-1 alpha-hydroxylase) (25-hydroxyvitamin d3 1- alpha-hydroxylase) (vd3 1a hydroxylase) (p450c1 alpha) (p450vd1- alpha). [swissprot;acc:o15528]	3915.4		3032.56	1.29112
		microfibril-associated glycoprotein 4 precursor. [swissprot;acc:p55083]	1865.5	High confidence	677.5	2.75351
20	0	beta-carotene dioxygenase 2; putative b,b-carotene-9',10'-dioxygenase. [refseq;acc:nm_031938]	139	Low confidence	570	4.10072
		ero1-like. [refseq;acc:nm_014584]	0.00001	High confidence	82	8200000
	1	protein phosphatase 1, regulatory subunit 14d; pkc-dependent pp1 inhibitory protein. [refseq;acc:nm_017726]	1865.5		677.5	2.75351
		retinoblastoma-associated factor 600. [refseq;acc:nm_020765]	9368.87	Low confidence	7256.71	1.29106
21	0	potassium voltage-gated channel, shal-related subfamily, member 2; voltage-sensitive potassium channel; voltage-gated potassium channel kv4.2. [refseq;acc:nm_012281]	434.911		111.278	3.90833
		syntaxin 10 (syn10). [swissprot;acc:o60499]	17.6611	High confidence	118.878	6.73106
	1	cytochrome p450 27, mitochondrial precursor (ec 1.14.-.-) (cytochrome p-450c27/25) (sterol 26-hydroxylase) (sterol 27-hydroxylase) (vitamin d(3) 25-hydroxylase) (5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol 27-hydroxylase). [swissprot;acc:q02318]	3917.88	Low confidence	3035.43	1.29072
		ficolin 2 precursor (collagen/fibrinogen domain-containing protein 2) (ficolin-b) (ficolin b) (serum lectin p35) (ebp-37) (hucolin) (l- ficolin). [swissprot;acc:q15485]	1865.5	High confidence	677.5	2.75351
22	0	carbohydrate (n-acetylglucosamine 6-o) sulfotransferase 6; macular dystrophy, corneal, 1; carbohydate sulfotransferase 6; corneal n-acetylglucosamine 6-sulfotransferase. [refseq;acc:nm_021615]	0.00001	Low confidence	37	3700000
		similar to lysozyme c-1 (1,4-beta-n-acylmuramidase c, ec 3.2.1.17). [refseq;acc:nm_032517]		High confidence	60	6000000
	1	cytochrome p450 24a1, mitochondrial precursor (ec 1.14.-.-) (p450- cc24) (vitamin d(3) 24-hydroxylase) (1,25-dihydroxyvitamin d(3) 24- hydroxylase) (24-ohase). [swissprot;acc:q07973]	3997.02	Low confidence	3126.88	1.27828
		protein phosphatase 1, regulatory (inhibitor) subunit 14c; serologically defined breast cancer antigen ny-br-81; pkc-potentiated pp1 inhibitory protein. [refseq;acc:nm_030949]	1865.5	High confidence	677.5	2.75351
23	0	carbohydrate (n-acetylglucosamine-6-o) sulfotransferase 2; carbohydrate (chondroitin 6/keratan) sulfotransferase 2. [refseq;acc:nm_004267]	0.00001	Low confidence	37	3700000
		guanine nucleotide-binding protein beta subunit-like protein 1 (g protein beta-subunit like protein 1) (wd40 repeat containing protein deleted in vcfs) (wdvcf protein) (fksg1 protein) (dgcrk3). [swissprot;acc:q9byb4]	59	High confidence	0.00001	5900000
	1	carboxypeptidase d precursor (ec 3.4.17.-) (gp180). [swissprot;acc:o75976]	32028.5	Low confidence	40899	1.27696
		gbp protein isoform a. [refseq;acc:nm_017870]	1894.39	High confidence	699.76	2.7072
24	0	cathepsin z precursor (ec 3.4.22.-) (cathepsin x) (cathepsin p). [swissprot;acc:q9ubr2]	493	Low confidence	154	3.2013
		ptd016 protein. [refseq;acc:nm_016125]	158	High confidence	30	5.26667
	1	atlastin; guanylate-binding protein 3. [refseq;acc:nm_015915]	4577.5	Low confidence	5720.25	1.24965
		protein kinase, interferon-inducible double stranded rna dependent activator; protein activator of the interferon-induced protein kinase. [refseq;acc:nm_003690]	2108.52	High confidence	950.561	2.21818
25	0	lim domain binding 1; carboxy terminal lim domain protein 2; lim domain-binding factor-1. [refseq;acc:nm_003893]	39.8063	Low confidence	12.6208	3.15402
		potential phospholipid-transporting atpase iia (ec 3.6.1.-). [swissprot;acc:o75110]	773	High confidence	148	5.22297
	1	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-7 subunit. [swissprot;acc:o60262]	892.67		1833.01	2.0534
		histidine triad nucleotide-binding protein 1 (adenosine 5'- monophosphoramidase) (protein kinase c inhibitor 1) (protein kinase c- interacting protein 1) (pkci-1). [swissprot;acc:p49773]	4691.96	Low confidence	5847.46	1.24627

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.