MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	description	Value Type	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 908 to 957 of 25824 in total

Interaction Map  : High confidence
Filtered  : 1

Rank	description	Value Type	Network Comparison Type	red	green	network_comparison
114	cyclin-dependent kinases regulatory subunit 1 (cks-1) (sid1334) (pnas-16 / pnas-143). [swissprot;acc:p33551]	Measured	Subtracted	13768.2	11466	2302.2
	guanine nucleotide-binding protein beta subunit 5 (transducin beta chain 5). [swissprot;acc:o14775]	Rooted		40.225	24.7051	15.5199
	huntingtin interacting protein c. [refseq;acc:nm_012272]	Measured	Divided	4300.47	5807.72	1.35048
	kh domain containing, rna binding, signal transduction associated 1; gap-associated tyrosine phosphoprotein p62 (sam68). [refseq;acc:nm_006559]	Ranked		332.874	267.246	1.24557
	myosin heavy chain, cardiac muscle beta isoform (myhc-beta). [swissprot;acc:p12883]	Squared		19321	12542.6	1.54043
115	28s ribosomal protein s17, mitochondrial precursor (mrp-s17) (hspc011). [swissprot;acc:q9y2r5]	Measured		21185	28492	1.34491
	dgcr14 protein (digeorge syndrome critical region 14) (es2 protein). [swissprot;acc:q96df8]	Rooted	Subtracted	21.4476	36.9459	15.4983
	dj756n5.1.1 (continues in em:al133324 as dj1161h23.3) (fragment). [sptrembl;acc:q9h430]	Squared	Divided	19321	12542.6	1.54043
	histone acetyltransferase type b catalytic subunit (ec 2.3.1.48). [swissprot;acc:o14929]	Ranked	Subtracted	277.546	240.461	37.085
	kh domain-containing, rna-binding, signal transduction-associated protein 2; sam68-like mammalian protein 1. [refseq;acc:nm_152688]		Divided	332.874	267.246	1.24557
	pnas-18. [sptrembl;acc:q9bzu3]	Measured	Subtracted	13680.5	11409.6	2270.9
	small glutamine rich protein with tetratricopeptide repeats 2. [refseq;acc:nm_019072]	Squared		72886.3	98544.5	25658.2
	spermatogenesis associated 6. [refseq;acc:nm_019073]	Rooted	Divided	80.4705	101.526	1.26165
116	amp deaminase 2 (ec 3.5.4.6) (amp deaminase isoform l). [swissprot;acc:q01433]
	guanine nucleotide-binding protein g(i)/g(s)/g(t) beta subunit 1 (transducin beta chain 1). [swissprot;acc:p04901]		Subtracted	40.6302	25.4452	15.185
	guanine nucleotide-binding protein g(i)/g(s)/g(t) beta subunit 3 (transducin beta chain 3). [swissprot;acc:p16520]	Ranked	Divided	268.565	334.483	1.24545
	high-mobility group 20b; sox-like transcriptional factor; swi/snf-related matrix-associated actin-dependent regulator of chromatin subfamily e, member 1-related. [refseq;acc:nm_006339]		Subtracted	208.52	171.595	36.925
	myosin heavy chain, skeletal muscle, extraocular (myhc-eo). [swissprot;acc:q9ukx3]	Squared	Divided	19321	12542.6	1.54043
	p66 alpha. [refseq;acc:nm_017660]		Subtracted	81888.8	56306.5	25582.3
	pantothenate kinase 1 (ec 2.7.1.33) (pantothenic acid kinase 1) (hpank1) (hpank). [swissprot;acc:q8te04]	Measured	Divided	21185	28492	1.34491
	ral guanine nucleotide dissociation stimulator-like 1 (ralgds-like 1). [swissprot;acc:q9nzl6]		Subtracted	13261.9	11017.8	2244.1
117	cleavage and polyadenylation specificity factor, 73 kda subunit (cpsf 73 kda subunit). [swissprot;acc:q9ukf6]	Squared	Divided	211446	137422	1.53866
	guanine nucleotide-binding protein beta subunit 4 (transducin beta chain 4). [swissprot;acc:q9hav0]	Rooted	Subtracted	40.5691	25.4263	15.1428
	high-mobility group 20a. [refseq;acc:nm_018200]	Ranked		208.588	171.778	36.81
	metalloprotease 1; metalloprotease 1 (pitrilysin family). [refseq;acc:nm_014889]	Measured		9276.47	7090.37	2186.1
	neuralized-like. [refseq;acc:nm_004210]	Ranked	Divided	332.326	266.948	1.24491
	pantothenate kinase 2, mitochondrial precursor (ec 2.7.1.33) (pantothenic acid kinase 2) (hpank2). [swissprot;acc:q9bz23]	Measured		21185	28492	1.34491
	transcription factor jun-b. [swissprot;acc:p17275]	Rooted		63.4173	79.5311	1.25409
	transcription repressor p66 beta component of the mecp1 complex. [refseq;acc:nm_020699]	Squared	Subtracted	81888.8	56306.5	25582.3
118	beta-1,4 mannosyltransferase. [refseq;acc:nm_019109]	Measured		9275.1	7089.65	2185.45
	homer, neuronal immediate early gene, 2; homer homolog 3 (drosophila). [refseq;acc:nm_004839]	Rooted	Divided	50.3065	62.9788	1.2519
	nadh-ubiquinone oxidoreductase subunit b17.2 (ec 1.6.5.3) (ec 1.6.99.3) (complex i-b17.2) (ci-b17.2) (cib17.2) (13 kda differentiation-associated protein). [swissprot;acc:q9ui09]	Ranked		284.753	228.934	1.24382
		Rooted	Subtracted	37.2205	52.2064	14.9859
	odd-skipped related 1; odz (odd oz/ten-m) related 1. [refseq;acc:nm_145260]	Ranked		274.027	237.79	36.237
	pantothenate kinase 3 (ec 2.7.1.33) (pantothenic acid kinase 3) (hpank3). [swissprot;acc:q9h999]	Measured	Divided	21185	28492	1.34491
	poly(a) polymerase alpha (ec 2.7.7.19) (pap) (polynucleotide adenylyltransferase alpha) (fragment). [swissprot;acc:p51003]	Squared		210445	136779	1.53858
	tyrosine aminotransferase (ec 2.6.1.5) (l-tyrosine:2-oxoglutarate aminotransferase) (tat). [swissprot;acc:p17735]		Subtracted	81888.8	56306.5	25582.3
119	acyl-coa dehydrogenase, very-long-chain specific, mitochondrial precursor (ec 1.3.99.-) (vlcad). [swissprot;acc:p49748]	Measured		12998.5	15138.2	2139.7
	adiponectin receptor 2. [refseq;acc:nm_024551]	Ranked		281.582	246.371	35.211
	cell division protein kinase 3 (ec 2.7.1.-). [swissprot;acc:q00526]	Squared		81606.8	56215.8	25391
	exocyst complex component sec5. [swissprot;acc:q96kp1]		Divided	210335	136716	1.53848
	mitochondrial solute carrier protein. [refseq;acc:nm_145305]	Measured		21185	28492	1.34491
	nadh-ubiquinone oxidoreductase 18 kda subunit, mitochondrial precursor (ec 1.6.5.3) (ec 1.6.99.3) (complex i-18 kda) (ci-18 kda) (complex i- aqdq) (ci-aqdq). [swissprot;acc:o43181]	Ranked		318.982	259.004	1.23157
	serine/threonine protein phosphatase 2a, 65 kda regulatory subunit a, beta isoform (pp2a, subunit a, pr65-beta isoform) (pp2a, subunit a, r1-beta isoform). [swissprot;acc:p30154]	Rooted	Subtracted	63.6507	48.7127	14.938
	ubiquinone biosynthesis protein coq7 homolog (coenzyme q biosynthesis protein 7 homolog) (timing protein clk-1 homolog). [swissprot;acc:q99807]		Divided	50.3247	62.9892	1.25166
120	g2/mitotic-specific cyclin b2. [swissprot;acc:o95067]	Squared	Subtracted	81592.1	56211.1	25381
	guanine nucleotide-binding protein g(i)/g(s)/g(t) beta subunit 3 (transducin beta chain 3). [swissprot;acc:p16520]	Rooted		40.081	25.1546	14.9264
	high-mobility group 20b; sox-like transcriptional factor; swi/snf-related matrix-associated actin-dependent regulator of chromatin subfamily e, member 1-related. [refseq;acc:nm_006339]	Measured	Divided	5136.78	6895.98	1.34247
	homer, neuronal immediate early gene, 1b. [refseq;acc:nm_004272]	Rooted		50.3333	62.9942	1.25154
	nucleolysin tia-1 (rna-binding protein tia-1) (p40-tia-1) [contains: p15-tia-1]. [swissprot;acc:p31483]	Ranked	Subtracted	227.199	192.715	34.484

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.