MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Gene	Rank	description	Network Comparison Type	Value Type	Interaction Map	Filtered	green	red	network_comparison

Results: HTML CSV LaTeX

Showing element 1351 to 1400 of 6456 in total

Value Type  : Ranked
Interaction Map  : High confidence
Filtered  : 1

Rank	description	Network Comparison Type	green	red	network_comparison
676	dna-directed rna polymerase ii 19 kda polypeptide (ec 2.7.7.6) (rpb7). [swissprot;acc:p52433]	Divided	245.613	232.469	1.05654
	ribosomal protein p0-like protein; 60s acidic ribosomal protein po; ribosomal protein, large, p0-like. [refseq;acc:nm_016183]	Subtracted	257.636	245.84	11.796
677	fibrillarin (34 kda nucleolar scleroderma antigen). [swissprot;acc:p22087]		233.483	245.246	11.763
	u6 snrna-associated sm-like protein lsm4 (glycine-rich protein) (grp). [swissprot;acc:q9y4z0]	Divided	216.745	228.944	1.05628
678	peptidylprolyl isomerase-like 4; cyclophilin-type peptidyl-prolyl cis-trans isomerase; ppiase; serologically defined breast cancer antigen ny-br-18. [refseq;acc:nm_139126]	Subtracted	214.405	226.135	11.73
	sorting nexin 5. [swissprot;acc:q9y5x3]	Divided	220.175	208.482	1.05609
679	homeobox protein hox-c4 (hox-3e) (cp19). [swissprot;acc:p09017]		125.389	132.413	1.05602
	sorting nexin 5. [swissprot;acc:q9y5x3]	Subtracted	220.175	208.482	11.693
680	homeobox protein hox-b4 (hox-2f) (hox-2.6). [swissprot;acc:p17483]	Divided	125.389	132.413	1.05602
	sr rich protein. [refseq;acc:nm_032870]	Subtracted	213.64	225.293	11.653
681	homeobox protein hox-c5 (hox-3d) (cp11). [swissprot;acc:q00444]	Divided	125.389	132.413	1.05602
	nuclear protein skip (ski-interacting protein) (snw1 protein) (nuclear receptor coactivator ncoa-62). [swissprot;acc:q13573]	Subtracted	208.987	220.593	11.606
682	homeobox protein hox-c6 (hox-3c) (hho.c8) (cp25). [swissprot;acc:p09630]	Divided	125.389	132.413	1.05602
	upf0202 protein kiaa1709. [swissprot;acc:q9h0a0]	Subtracted	234.458	246.055	11.597
683	homeobox protein hox-d4 (hox-4b) (hox-5.1) (hho.c13). [swissprot;acc:p09016]	Divided	125.389	132.413	1.05602
	osteoclast stimulating factor 1. [swissprot;acc:q92882]	Subtracted	243.289	231.809	11.48
684	homeobox protein hox-b5 (hox-2a) (hho.c10) (hu-1). [swissprot;acc:p09067]	Divided	125.389	132.413	1.05602
	phosphoribosylformylglycinamidine synthase (ec 6.3.5.3) (fgam synthase) (fgams) (formylglycinamide ribotide amidotransferase) (fgarat) (formylglycinamide ribotide synthetase). [swissprot;acc:o15067]	Subtracted	235.027	223.58	11.447
685	bifunctional purine biosynthesis protein purh [includes: phosphoribosylaminoimidazolecarboxamide formyltransferase (ec 2.1.2.3) (aicar transformylase); imp cyclohydrolase (ec 3.5.4.10) (inosinicase) (imp synthetase) (atic)]. [swissprot;acc:p31939]
	homeobox protein hox-a5 (hox-1c). [swissprot;acc:p20719]	Divided	125.389	132.413	1.05602
686	homeobox protein hox-a4 (hox-1d) (hox-1.4). [swissprot;acc:q00056]
	multifunctional protein ade2 [includes: phosphoribosylaminoimidazole- succinocarboxamide synthase (ec 6.3.2.6) (saicar synthetase); phosphoribosylaminoimidazole carboxylase (ec 4.1.1.21) (air carboxylase) (airc)]. [swissprot;acc:p22234]	Subtracted	235.027	223.58	11.447
687	dendritic cell protein. [refseq;acc:nm_006360]		211.685	223.121	11.436
	retinal short-chain dehydrogenase/reductase 3. [refseq;acc:nm_016246]	Divided	125.389	132.413	1.05602
688	dna-directed rna polymerase ii 16 kda polypeptide (ec 2.7.7.6) (rpb4). [swissprot;acc:o15514]		250.823	237.554	1.05586
	potential carboxypeptidase-like protein x2 precursor. [swissprot;acc:q8n436]	Subtracted	211.685	223.121	11.436
689	carboxypeptidase n catalytic chain precursor (ec 3.4.17.3) (arginine carboxypeptidase) (kininase 1) (serum carboxypeptidase n) (scpn) (anaphylatoxin inactivator) (plasma carboxypeptidase b). [swissprot;acc:p15169]
	t-complex protein 1, alpha subunit (tcp-1-alpha) (cct-alpha). [swissprot;acc:p17987]	Divided	128.225	135.379	1.05579
690	cpz gene product. [refseq;acc:nm_003652]	Subtracted	211.685	223.121	11.436
	nuclear protein skip (ski-interacting protein) (snw1 protein) (nuclear receptor coactivator ncoa-62). [swissprot;acc:q13573]	Divided	208.987	220.593	1.05553
691	breast carcinoma amplified sequence 2; spliceosome associated protein, amplified in breast cancer. [refseq;acc:nm_005872]		206.195	217.602	1.05532
	carboxypeptidase h precursor (ec 3.4.17.10) (cph) (carboxypeptidase e) (cpe) (enkephalin convertase) (prohormone processing carboxypeptidase). [swissprot;acc:p16870]	Subtracted	211.685	223.121	11.436
692	cdc5-like; cdc5 (cell division cycle 5, s. pombe, homolog)-like; cell division cycle 5, s. pombe, homolog-like; cdc5-related protein. [refseq;acc:nm_001253]	Divided	206.195	217.602	1.05532
	potential carboxypeptidase x precursor (ec 3.4.17.-) (metallocarboxypeptidase cpx-1). [swissprot;acc:q96sm3]	Subtracted	211.685	223.121	11.436
693	breast carcinoma amplified sequence 2; spliceosome associated protein, amplified in breast cancer. [refseq;acc:nm_005872]		206.195	217.602	11.407
	rna-binding protein nova-1 (neuro-oncological ventral antigen 1) (onconeural ventral antigen-1) (paraneoplastic ri antigen) (ventral neuron-specific protein 1). [swissprot;acc:p51513]	Divided	234.847	222.554	1.05524
694	cdc5-like; cdc5 (cell division cycle 5, s. pombe, homolog)-like; cell division cycle 5, s. pombe, homolog-like; cdc5-related protein. [refseq;acc:nm_001253]	Subtracted	206.195	217.602	11.407
	dna polymerase epsilon, catalytic subunit a (ec 2.7.7.7) (dna polymerase ii subunit a). [swissprot;acc:q07864]	Divided	229.35	241.907	1.05475
695	nucleotide-binding protein 1 (nbp 1). [swissprot;acc:p53384]	Subtracted	199.398	210.739	11.341
	peptidylprolyl isomerase-like 4; cyclophilin-type peptidyl-prolyl cis-trans isomerase; ppiase; serologically defined breast cancer antigen ny-br-18. [refseq;acc:nm_139126]	Divided	214.405	226.135	1.05471
696	nucleotide binding protein 2 (nbp 2). [swissprot;acc:q9y5y2]	Subtracted	199.398	210.739	11.341
	sr rich protein. [refseq;acc:nm_032870]	Divided	213.64	225.293	1.05455
697	ferritin heavy chain (ferritin h subunit). [swissprot;acc:p02794]		209.113	220.444	1.05419
		Subtracted			11.331
698	cellular repressor of e1a-stimulated genes 2. [refseq;acc:nm_153836]		209.118	220.438	11.32
	mitochondrial ferritin; ferritin heavy chain-like; ferritin h subunit. [refseq;acc:nm_177478]	Divided		220.437	1.05413
699	cellular repressor of e1a-stimulated genes 2. [refseq;acc:nm_153836]			220.438
	dj681n20.2 (novel protein similar to ferritin, light polypeptide (ftl)). [sptrembl;acc:q9byw6]	Subtracted			11.32
700	disks large-associated protein 1 (dap-1) (guanylate kinase-associated protein) (hgkap) (sap90/psd-95-associated protein 1) (sapap1) (psd- 95/sap90 binding protein 1). [swissprot;acc:o14490]
	dj681n20.2 (novel protein similar to ferritin, light polypeptide (ftl)). [sptrembl;acc:q9byw6]	Divided			1.05413

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.