MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	Hugo	description	Value Type	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 2012 to 2061 of 3228 in total

Value Type  : Ranked
Network Comparison Type  : Divided
Interaction Map  : High confidence
Filtered  : 1

Rank	Hugo	description	red	green	network_comparison
2012	DDX43	dead-box protein. [refseq;acc:nm_018665]	193.517	191.766	1.00913
2013	PPP1R12B	protein phosphatase 1, regulatory (inhibitor) subunit 12b isoform a; myosin phosphatase regulatory subunit; myosin phosphatase, target subunit 2. [refseq;acc:nm_002481]	217.662	215.693
2014	PPP1R12A	protein phosphatase 1, regulatory (inhibitor) subunit 12a; myosin phosphatase, target subunit 1. [refseq;acc:nm_002480]	217.676	215.709	1.00912
2015	TOP3A	dna topoisomerase iii alpha (ec 5.99.1.2). [swissprot;acc:q13472]	217.941	215.979	1.00908
2016	ETFDH	electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial precursor (ec 1.5.5.1) (etf-qo) (etf-ubiquinone oxidoreductase) (etf dehydrogenase) (electron-transferring- flavoprotein dehydrogenase). [swissprot;acc:q16134]	199.092	197.301
2017	RRS1	ribosome biogenesis regulatory protein homolog. [swissprot;acc:q15050]	127.397	128.553	1.00907
2018	PPP1CA	serine/threonine protein phosphatase pp1-alpha 1 catalytic subunit (ec 3.1.3.16) (pp-1a). [swissprot;acc:p08129]
2019	no value	acyl-coa dehydrogenase, short/branched chain specific, mitochondrial precursor (ec 1.3.99.-) (sbcad) (2-methyl branched chain acyl-coa dehydrogenase) (2-mebcad) (2-methylbutyryl-coenzyme a dehydrogenase) (2-methylbutyryl-coa dehydrogenase). [swissprot;acc:p45954]	215.799	213.865	1.00904
2020	KIAA0664	putative eukaryotic translation initiation factor 3 subunit (eif-3) (fragment). [swissprot;acc:o75153]	223.168	221.176	1.00901
2021	COQ3	hexaprenyldihydroxybenzoate methyltransferase, mitochondrial precursor (ec 2.1.1.114) (dihydroxyhexaprenylbenzoate methyltransferase) (3,4- dihydroxy-5-hexaprenylbenzoate methyltransferase) (dhhb methyltransferase) (dhhb-mt) (dhhb-mtase). [swissprot;acc:q9nzj6]	208.601	210.464	1.00893
2022	ATP5S	atp synthase coupling factor b, mitochondrial precursor. [swissprot;acc:q99766]
2023	GDA	guanine deaminase (ec 3.5.4.3) (guanase) (guanine aminase) (guanine aminohydrolase) (gah) (p51-nedasin). [swissprot;acc:q9y2t3]
2024	VPS33B	vacuolar protein sorting 33b (hvps33b). [swissprot;acc:q9h267]	215.553	213.663	1.00885
2025	GPT	alanine aminotransferase (ec 2.6.1.2) (glutamic--pyruvic transaminase) (gpt) (glutamic--alanine transaminase). [swissprot;acc:p24298]	189.987	191.668
2026	VPS11	vacuolar protein sorting 11 (hvps11) (pp3476). [swissprot;acc:q9h270]	215.553	213.663
2027	LIN7C	lin-7 homolog c; lin-7 protein 3. [refseq;acc:nm_018362]	225.015	223.041
2028	VPS33A	vacuolar protein sorting 33a (hvps33a). [swissprot;acc:q96ax1]	215.553	213.663
2029	CCBL1	cytoplasmic cysteine conjugate-beta lyase; glutamine-phenylpyruvate aminotransferase. [refseq;acc:nm_004059]	189.999	191.677	1.00883
2030	GPT2	alanine aminotransferase 2; glutamic-pyruvate transaminase 2. [refseq;acc:nm_133443]
2031	TTRAP	traf and tnf receptor-associated protein; ets1-associated protein 2. [refseq;acc:nm_016614]	218.466	216.562	1.00879
2032	CAPZA3	f-actin capping protein alpha-3 subunit (capz alpha-3) (germ cell- specific protein 3). [swissprot;acc:q96kx2]	215.322	213.46	1.00872
2033	CAPZB	f-actin capping protein beta subunit (capz beta). [swissprot;acc:p47756]
2034	CENTB5	centaurin beta 5 (cnt-b5). [swissprot;acc:q96p50]	218.919	220.812	1.00865
2035	CENTB2	centaurin beta 2 (cnt-b2). [swissprot;acc:q15057]
2036	LMNB1	lamin b1. [swissprot;acc:p20700]		220.813
2037	CENTB1	centaurin beta 1 (cnt-b1). [swissprot;acc:q15027]		220.812
2038	LMNA	lamin a/c (70 kda lamin). [swissprot;acc:p02545]	218.92	220.811	1.00864
2039	ACSS2	acetyl-coenzyme a synthetase, cytoplasmic (ec 6.2.1.1) (acetate--coa ligase) (acyl-activating enzyme) (acetyl-coa synthetase) (acs) (acecs). [swissprot;acc:q9nr19]	190.551	192.191	1.00861
2040	T	brachyury protein (t protein). [swissprot;acc:o15178]	210.586	208.803	1.00854
2041	UBQLN4	ataxin-1 ubiquitin-like interacting protein. [refseq;acc:nm_020131]	196.808	195.141
2042	TBX19	t-box transcription factor tbx19 (t-box protein 19). [swissprot;acc:o60806]	210.586	208.803
2043	UBQLN1	ubiquilin 1 isoform 1. [refseq;acc:nm_013438]	196.837	195.173	1.00853
2044	AP3B1	adapter-related protein complex 3 beta 1 subunit (beta-adaptin 3a) (ap-3 complex beta-3a subunit) (beta-3a-adaptin). [swissprot;acc:o00203]	199.928	198.24	1.00851
2045	C19orf29	ny-ren-24 antigen (fragment). [sptrembl;acc:q9y5a4]
2046	no value	adapter-related protein complex 3 beta 2 subunit (beta-adaptin 3b) (ap-3 complex beta-3b subunit) (beta-3b-adaptin) (neuron-specific vesicle coat protein beta-nap). [swissprot;acc:q13367]
2047	SLC2A6	solute carrier family 2, facilitated glucose transporter, member 6 (glucose transporter type 6) (glucose transporter type 9). [swissprot;acc:q9ugq3]	224.124	226.003	1.00838
2048	SLC2A8	solute carrier family 2, facilitated glucose transporter, member 8 (glucose transporter type 8) (glucose transporter type x1). [swissprot;acc:q9ny64]
2049	EIF2B2	translation initiation factor eif-2b beta subunit (eif-2b gdp-gtp exchange factor) (s20i15) (s20iii15). [swissprot;acc:p49770]	220.787	222.634	1.00837
2050	SH3BGR	sh3 domain-binding glutamic acid-rich protein (sh3bgr protein) (21- glutamic acid-rich protein) (21-garp). [swissprot;acc:p55822]	218.79	216.981	1.00834
2051	OXR1	oxidation resistance 1. [refseq;acc:nm_181354]
2052	AZIN1	ornithine decarboxylase antizyme inhibitor. [swissprot;acc:o14977]	207.667	205.95
2053	LATS2	lats, large tumor suppressor, homolog 2; lats (large tumor suppressor, drosophila) homolog 2. [refseq;acc:nm_014572]	218.79	216.981
2054	ADC	ornithine decarboxylase-like protein (ec 4.1.1.17) (odc-paralogue) (odc-p). [swissprot;acc:q96a70]	207.665	205.948
2055	DYM	dymeclin. [refseq;acc:nm_017653]	218.79	216.981
2056	SH3BGRL	sh3 domain-binding glutamic acid-rich-like protein. [swissprot;acc:o75368]
2057	LATS1	lats homolog 1. [refseq;acc:nm_004690]
2058	no value	sh3 domain-binding glutamic acid-rich-like protein 2 (fovea-associated sh3 domain binding protein). [swissprot;acc:q9ujc5]
2059	NCOA7	nuclear receptor coactivator 7; estrogen receptor associated protein 140 kda. [refseq;acc:nm_181782]
2060	C20orf118	dj132f21.2 (contains a novel protein similar to the l82e from drosophila) (fragment). [sptrembl;acc:q9h125]
2061	TBC1D22B	tbc1 domain family protein c22orf4-like (fragment). [swissprot;acc:q9nu19]

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.