MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	Hugo	description	Value Type	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 2308 to 2357 of 6456 in total

Value Type  : Ranked
Interaction Map  : High confidence
Filtered  : 1

Rank	Hugo	description	Network Comparison Type	red	green	network_comparison
1154	PPA1	inorganic pyrophosphatase (ec 3.6.1.1) (pyrophosphate phospho- hydrolase) (ppase). [swissprot;acc:q15181]	Divided	224.307	230.242	1.02646
1155	ATP6V0B	vacuolar atp synthase 21 kda proteolipid subunit (ec 3.6.3.14) (hatpl). [swissprot;acc:q99437]	Subtracted	218.186	212.672	5.514
	PPA2	inorganic pyrophosphatase 2 isoform 1. [refseq;acc:nm_176869]	Divided	224.307	230.242	1.02646
1156	AIPL1	aryl-hydrocarbon interacting protein-like 1. [swissprot;acc:q9nzn9]
	SGCG	gamma-sarcoglycan (gamma-sg) (35 kda dystrophin-associated glycoprotein) (35dag). [swissprot;acc:q13326]	Subtracted	218.186	212.672	5.514
1157	AIP	ah receptor-interacting protein (aip) (immunophilin homolog ara9) (hbv-x associated protein 2). [swissprot;acc:o00170]	Divided	224.307	230.242	1.02646
	UBP1	upstream binding protein 1 (lbp-1a). [refseq;acc:nm_014517]	Subtracted	220.742	215.237	5.505
1158	EPS8L2	epidermal growth factor receptor pathway substrate 8-like protein 2; eps8-related protein 2; epidermal growth factor receptor pathway substrate 8-related protein 2. [refseq;acc:nm_022772]	Divided	221.877	216.167	1.02641
	TFCP2	transcription factor cp2; transcription factor cp2, alpha globin. [refseq;acc:nm_005653]	Subtracted	220.742	215.237	5.505
1159	PROSC	proline synthetase co-transcribed bacterial homolog protein. [swissprot;acc:o94903]	Divided	170.28	165.898	1.02641
	TFCP2L1	lbp-9. [refseq;acc:nm_014553]	Subtracted	220.742	215.237	5.505
1160	OGDH	2-oxoglutarate dehydrogenase e1 component, mitochondrial precursor (ec 1.2.4.2) (alpha-ketoglutarate dehydrogenase). [swissprot;acc:q02218]	Divided	208.55	214.041	1.02633
	SFRS3	splicing factor, arginine/serine-rich 3 (pre-mrna splicing factor srp20) (x16 protein). [swissprot;acc:p23152]	Subtracted	220.742	215.237	5.505
1161	no value	adp-ribosylation factor-like protein 7 (adp-ribosylation factor-like protein lak). [swissprot;acc:p56559]		218.402	212.904	5.498
		kappa b-ras 1. [refseq;acc:nm_020345]	Divided	220.758	215.097	1.02632
1162	ATP6V0D1	vacuolar atp synthase subunit d (ec 3.6.3.14) (v-atpase d subunit) (vacuolar proton pump d subunit) (v-atpase ac39 subunit) (v-atpase 40 kda accessory protein) (p39) (32 kda accessory protein). [swissprot;acc:p12953]	Subtracted	218.402	212.904	5.498
	NKIRAS2	i-kappa-b-interacting ras-like protein 2. [refseq;acc:nm_017595]	Divided	220.758	215.097	1.02632
1163	ARL4A	adp-ribosylation factor-like protein 4. [swissprot;acc:p40617]	Subtracted	218.402	212.904	5.498
	SNAPAP	snare associated protein snapin. [refseq;acc:nm_012437]	Divided	220.758	215.097	1.02632
1164	OGDH	2-oxoglutarate dehydrogenase e1 component, mitochondrial precursor (ec 1.2.4.2) (alpha-ketoglutarate dehydrogenase). [swissprot;acc:q02218]	Subtracted	208.55	214.041	5.491
	TLE4	transducin-like enhancer protein 4. [swissprot;acc:q04727]	Divided	219.438	213.818	1.02628
1165	CASP7	caspase-7 precursor (ec 3.4.22.-) (ice-like apoptotic protease 3) (ice-lap3) (apoptotic protease mch-3) (cmh-1). [swissprot;acc:p55210]	Subtracted	233.942	228.46	5.482
	TLE3	transducin-like enhancer protein 3 (esg3). [swissprot;acc:q04726]	Divided	219.401	213.785	1.02627
1166	CASP3	apopain precursor (ec 3.4.22.-) (cysteine protease cpp32) (yama protein) (cpp-32) (caspase-3) (casp-3) (srebp cleavage activity 1) (sca-1). [swissprot;acc:p42574]	Subtracted	233.942	228.46	5.482
	TLE2	transducin-like enhancer protein 2 (esg2). [swissprot;acc:q04725]	Divided	219.374	213.759	1.02627
1167	EN2	homeobox protein engrailed-2 (hu-en-2). [swissprot;acc:p19622]		219.399	213.784	1.02626
	KCTD10	mstp028 protein. [refseq;acc:nm_031954]	Subtracted	219.042	213.6	5.442
1168	CXXC1	cpg binding protein (protein containing phd finger and cxxc domain 1). [swissprot;acc:q9p0u4]	Divided	219.399	213.784	1.02626
	SMARCB1	swi/snf related, matrix associated, actin dependent regulator of chromatin subfamily b member 1 (integrase interactor 1 protein) (hsnf5) (baf47). [swissprot;acc:q12824]	Subtracted	219.03	213.604	5.426
1169	ABT1	activator of basal transcription 1; tata-binding protein-binding protein; basal transcriptional activator. [refseq;acc:nm_013375]	Divided	219.399	213.784	1.02626
	TNFAIP1	tumor necrosis factor, alpha-induced protein 1, endothelial (b12 protein). [swissprot;acc:q13829]	Subtracted	219.023	213.606	5.417
1170	no value	cytokine-like nuclear factor n-pac. [refseq;acc:nm_032569]	Divided	219.399	213.784	1.02626
	KCTD13	polymerase delta-interacting protein 1; tnfaip1-like. [refseq;acc:nm_178863]	Subtracted	219.022	213.607	5.415
1171	DYNLT3	t-complex associated-testis-expressed 1-like (protein 91/23). [swissprot;acc:p51808]		173.475	178.889	5.414
	HECW1	hect type e3 ubiquitin ligase. [refseq;acc:nm_015052]	Divided	219.399	213.784	1.02626
1172	no value	transducin-like enhancer protein 1 (esg1). [swissprot;acc:q04724]		219.375	213.767	1.02623
	MRE11A	double-strand break repair protein mre11a (mre11 homolog 1). [swissprot;acc:p49959]	Subtracted	173.475	178.889	5.414
1173	COPB1	coatomer beta subunit (beta-coat protein) (beta-cop). [swissprot;acc:p53618]		171.341	176.746	5.405
	DPH1	candidate tumor suppressor in ovarian cancer 2. [refseq;acc:nm_080822]	Divided	229.243	235.246	1.02619
1174	C11orf2	chromosome 11 open reading frame2; chromosome 11 open reading frame2. [refseq;acc:nm_013265]	Subtracted	214.364	219.759	5.395
	COPE	coatomer epsilon subunit (epsilon-coat protein) (epsilon-cop). [swissprot;acc:o14579]	Divided	187.964	192.849	1.02599
1175	ATP6V0C	vacuolar atp synthase 16 kda proteolipid subunit (ec 3.6.3.14). [swissprot;acc:p27449]		218.186	212.672	1.02593
	KIF13A	kinesin-like protein kif13a (kinesin-like protein rbkin). [swissprot;acc:q9h1h9]	Subtracted	214.364	219.759	5.395
1176	COG2	conserved oligomeric golgi complex component 2 (low density lipoprotein receptor defect c-complementing protein). [swissprot;acc:q14746]
	SGCZ	sarcoglycan zeta; zeta-sarcoglycan. [refseq;acc:nm_139167]	Divided	218.186	212.672	1.02593
1177	no value	kinesin-like protein kif13b (kinesin-like protein gakin). [swissprot;acc:q9nqt8]	Subtracted	214.364	219.759	5.395
	ACBD3	golgi complex associated protein 1; golgi resident protein gcp60; peripherial benzodiazepine receptor associated protein; golgi phosphoprotein 1; pbr associated protein; pka (rialpha)-associated protein. [refseq;acc:nm_022735]	Divided	218.186	212.672	1.02593
1178	MTX1	metaxin 1. [swissprot;acc:q13505]	Subtracted	199.552	204.925	5.373
	SGCD	delta-sarcoglycan (sg-delta) (35 kda dystrophin-associated glycoprotein) (35dag). [swissprot;acc:q92629]	Divided	218.186	212.672	1.02593
1179	no value	keratin associated protein 9-4; keratin associated protein 9.4. [refseq;acc:nm_033191]	Subtracted	219.356	224.723	5.367

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.