MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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description	Rank	Gene	Value Type	Hugo	Network Comparison Type	Interaction Map	Filtered	red	network_comparison	green

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Showing element 2051 to 2100 of 16578 in total

Value Type  : Ranked
Filtered  : 1

description	Rank	Hugo	Network Comparison Type	Interaction Map	red	network_comparison	green
biotin--protein ligase (ec 6.3.4.-) (biotin apo-protein ligase) [includes: biotin--[methylmalonyl-coa-carboxyltransferase] ligase (ec 6.3.4.9); biotin--[propionyl-coa-carboxylase [atp-hydrolyzing]] ligase (ec 6.3.4.10) (holocarboxylase synthetase) (hcs); biotin--[methylcrotonoyl-coa-carboxylase] ligase (ec 6.3.4.11); biotin--[acetyl-coa-carboxylase] ligase (ec 6.3.4.15)]. [swissprot;acc:p50747]	2150	HLCS	Divided	Low confidence	199.129	1.0191	195.396
	2210		Subtracted			3.733
bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) (ec 3.6.1.17) (diadenosine 5',5'''-p1,p4-tetraphosphate asymmetrical hydrolase) (diadenosine tetraphosphatase) (ap4a hydrolase) (ap4aase). [swissprot;acc:p50583]	4100	NUDT2	Divided		202.893	1.01079	200.728
	4101		Subtracted			2.165
bisphosphoglycerate mutase (ec 5.4.2.4) (2,3-bisphosphoglycerate mutase, erythrocyte) (2,3-bisphosphoglycerate synthase) (bpgm) (ec 5.4.2.1) (ec 3.1.3.13) (bpg-dependent pgam). [swissprot;acc:p07738]	4581	BPGM	Divided		202.246	1.00752	200.737
			Subtracted			1.509
bladder cancer-associated protein (bladder cancer 10 kda protein) (bc10). [swissprot;acc:o60629]	3276	BLCAP			202.983	3.134	199.849
	3287		Divided			1.01568
bleomycin hydrolase (ec 3.4.22.40) (blm hydrolase) (bmh) (bh). [swissprot;acc:q13867]	1149	BLMH	Subtracted		202.963	4.585	198.378
	1190		Divided			1.02311
block 23. [sptrembl;acc:q8nhw5]	1021	no value	Subtracted	High confidence	226.205	6.653	232.858
	1091		Divided			1.02941
	3893		Subtracted	Low confidence	202.202	2.529	199.673
	3896		Divided			1.01267
block of proliferation 1. [swissprot;acc:q14137]	438	BOP1	Subtracted	High confidence	250.794	16.361	234.433
	512		Divided			1.06979
	1026		Subtracted	Low confidence	201.77	4.774	196.996
	1038		Divided			1.02423
blocked early in transport 1 homolog (s. cerevisiae) like; golgi snare 15 kda protein. [refseq;acc:nm_016526]	340	BET1L			201.827	1.03939	194.178
	347		Subtracted			7.649
blood group rh(ce) polypeptide (rhesus c/e antigens) (rh30a) (rhixb) (rh polypeptide 1) (rhpi). [swissprot;acc:p18577]	901	no value	Divided		201.015	1.0253	196.054
	903
	910		Subtracted			4.961
	911
	1930		Divided	High confidence	196.964	1.01001	198.935
	1932				196.965		198.936
	1987		Subtracted		196.964	1.971	198.935
	1988				196.965		198.936
blood group rh(d) polypeptide (rhesus d antigen) (rhxiii) (rh polypeptide 2) (rhpii). [swissprot;acc:q02161]	900	RHD	Divided	Low confidence	201.015	1.0253	196.054
	909		Subtracted			4.961
	1928		Divided	High confidence	196.964	1.01001	198.935
	1986		Subtracted			1.971
bloom's syndrome protein (ec 3.6.1.-) (recq protein-like 3) (dna helicase, recq-like, type 2). [swissprot;acc:p54132]	1748	no value	Divided		215.673	1.01269	212.971
	1756		Subtracted			2.702
	2254			Low confidence	199.902	3.703	196.199
	2256		Divided			1.01887
bomapin (protease inhibitor 10) (serpin b10). [swissprot;acc:p48595]	759	SERPINB10	Subtracted	High confidence	224.244	10.267	234.511
	793		Divided			1.04578
	3795		Subtracted	Low confidence	202.443	2.656	199.787
	3797		Divided			1.01329
bombesin receptor subtype-3 (brs-3). [swissprot;acc:p32247]	216	BRS3	Subtracted		199.671	9.983	209.654
	218		Divided			1.05
bone morphogenetic protein 1 precursor (ec 3.4.24.19) (bmp-1) (procollagen c-proteinase) (pcp) (mammalian tolloid protein) (mtld). [swissprot;acc:p13497]	1921	BMP1	Subtracted		203.84	3.888	199.952
	2008		Divided			1.01944
bone morphogenetic protein 4 precursor (bmp-4) (bmp-2b). [swissprot;acc:p12644]	4081	BMP4			195.995	1.01104	193.854
	4126		Subtracted			2.141
bone morphogenetic protein 5 precursor (bmp-5). [swissprot;acc:p22003]	2846	BMP5			203.478	3.402	200.076
	2928		Divided			1.017
	3069			High confidence	0.00001	1	0.00001
			Subtracted		0	0	0

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.