MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Value Type	Gene	description	Network Comparison Type	Filtered	Interaction Map	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 4158 to 4207 of 25824 in total

Filtered  : 1
Interaction Map  : High confidence

Rank	Value Type	description	Network Comparison Type	red	green	network_comparison
520	Squared	paxillin. [swissprot;acc:p49023]	Divided	22387.1	26827.3	1.19834
	Rooted	breast carcinoma amplified sequence 2; spliceosome associated protein, amplified in breast cancer. [refseq;acc:nm_005872]		61.1902	66.6503	1.08923
		cell division control protein 2 homolog (ec 2.7.1.-) (p34 protein kinase) (cyclin-dependent kinase 1) (cdk1). [swissprot;acc:p06493]	Subtracted	93.5619	88.4001	5.1618
521	Measured	probable calcium-transporting atpase kiaa0703 (ec 3.6.3.8). [swissprot;acc:o75185]		6143.52	6950.75	807.23
		u4/u6-associated rna splicing factor. [refseq;acc:nm_004698]	Divided	5390.78	6142.07	1.13937
	Ranked	exosome complex exonuclease rrp41 (ec 3.1.13.-) (ribosomal rna processing protein 41) (p12a). [swissprot;acc:q9npd3]		215.237	230.07	1.06891
		segment polarity protein dishevelled homolog dvl-3 (dishevelled-3) (dsh homolog 3). [swissprot;acc:q92997]	Subtracted	218.702	204.582	14.12
	Squared	carboxypeptidase a5. [refseq;acc:nm_080385]	Divided	53174	44377.4	1.19822
		keratin associated protein 1.5. [refseq;acc:nm_031957]	Subtracted	31100.2	36086.5	4986.3
	Rooted	cdc5-like; cdc5 (cell division cycle 5, s. pombe, homolog)-like; cell division cycle 5, s. pombe, homolog-like; cdc5-related protein. [refseq;acc:nm_001253]	Divided	61.1902	66.6503	1.08923
		nnp-1 protein (novel nuclear protein 1) (nucleolar protein nop52) (nop52) (d21s2056e). [swissprot;acc:p56182]	Subtracted	49.5225	54.6817	5.1592
522	Measured	calcium-transporting atpase type 2c, member 1 (ec 3.6.3.8) (atpase 2c1) (atp-dependent ca(2+) pump pmr1) (hussy-28). [swissprot;acc:p98194]		6148.94	6955.76	806.82
		glycogen [starch] synthase, liver (ec 2.4.1.11). [swissprot;acc:p54840]	Divided	9634.98	10976.2	1.1392
	Ranked	pleiotropic regulator 1 (prl1homolog, arabidopsis); pleiotropic regulator 1 (prl1, arabidopsis homolog). [refseq;acc:nm_002669]		222.893	208.523	1.06891
		splicing factor arginine/serine-rich 11 (arginine-rich 54 kda nuclear protein) (p54). [swissprot;acc:q05519]	Subtracted	229.709	215.631	14.078
	Squared	carboxypeptidase b precursor (ec 3.4.17.2) (pancreas-specific protein) (pasp). [swissprot;acc:p15086]	Divided	53174	44377.4	1.19822
		star-related lipid transfer protein 6 (stard6) (start domain- containing protein 6). [swissprot;acc:p59095]	Subtracted	31100.1	36086.4	4986.3
	Rooted	dna polymerase epsilon, catalytic subunit a (ec 2.7.7.7) (dna polymerase ii subunit a). [swissprot;acc:q07864]		51.7959	56.9253	5.1294
		septin 10 isoform 1. [refseq;acc:nm_144710]	Divided	113.733	123.871	1.08914
523	Measured	aquaporin 4 (wch4) (mercurial-insensitive water channel) (miwc). [swissprot;acc:p55087]		10640.2	12117.8	1.13887
		dolichol-phosphate mannosyltransferase (ec 2.4.1.83) (dolichol- phosphate mannose synthase) (dolichyl-phosphate beta-d- mannosyltransferase) (mannose-p-dolichol synthase) (mpd synthase) (dpm synthase). [swissprot;acc:o60762]	Subtracted	5865.79	6671.23	805.44
	Ranked	exosome complex exonuclease rrp4 (ec 3.1.13.-) (ribosomal rna processing protein 4). [swissprot;acc:q13868]	Divided	215.237	230.07	1.06891
		histone h2b.c (h2b/c). [swissprot;acc:q99880]	Subtracted	247.47	233.441	14.029
	Squared	keratin, ultra high-sulfur matrix protein b (uhs keratin b) (uhs kerb). [swissprot;acc:o75690]		31100.2	36086.5	4986.3
		neutral and basic amino acid transport protein rbat (b(0,+)-type amino acid transport protein) (nbat) (d2h). [swissprot;acc:q07837]	Divided	53174	44377.4	1.19822
	Rooted	ribonucleoside-diphosphate reductase m1 chain (ec 1.17.4.1) (ribonucleotide reductase large chain). [swissprot;acc:p23921]		66.377	72.2842	1.08899
		zinc finger-like protein 9. [refseq;acc:nm_033414]	Subtracted	49.3451	54.4606	5.1155
524	Measured	aquaporin 5. [swissprot;acc:p55064]	Divided	10640	12117.6	1.13887
		nuclear rna export factor 5 (tap-like protein 1) (tapl-1). [swissprot;acc:q9h1b4]	Subtracted	5206.9	6010.04	803.14
	Ranked	exosome complex exonuclease rrp40 (ec 3.1.13.-) (ribosomal rna processing protein 40) (p10) (cgi-102). [swissprot;acc:q9nqt5]	Divided	215.237	230.07	1.06891
		histone h2b.q (h2b/q) (h2b-gl105). [swissprot;acc:q16778]	Subtracted	247.47	233.441	14.029
	Squared	aminoacylase-1 (ec 3.5.1.14) (n-acyl-l-amino-acid amidohydrolase) (acy-1). [swissprot;acc:q03154]	Divided	53174	44377.4	1.19822
		keratin, ultra high-sulfur matrix protein a (uhs keratin a) (uhs kera). [swissprot;acc:p26371]	Subtracted	31100.2	36086.5	4986.3
	Rooted	brain protein 44. [swissprot;acc:o95563]	Divided	113.374	123.463	1.08899
		membrane-associated transporter protein (aim-1 protein) (melanoma antigen aim1). [swissprot;acc:q9umx9]	Subtracted	49.3451	54.4606	5.1155
525	Measured	lens fiber major intrinsic protein (mip26) (mp26) (aquaporin 0). [swissprot;acc:p30301]	Divided	10639.8	12117.3	1.13887
		nuclear rna export factor 3 (tap-like protein 3) (tapl-3). [swissprot;acc:q9h4d5]	Subtracted	5207.03	6010.1	803.07
	Ranked	exosome complex exonuclease rrp46 (ec 3.1.13.-) (ribosomal rna processing protein 46) (p12b) (chronic myelogenous leukemia tumor antigen 28). [swissprot;acc:q9nqt4]	Divided	215.237	230.07	1.06891
		histone h3.1 (h3/a) (h3/c) (h3/d) (h3/f) (h3/h) (h3/i) (h3/j) (h3/k) (h3/l). [swissprot;acc:p16106]	Subtracted	247.47	233.441	14.029
	Squared	carboxypeptidase a1 precursor (ec 3.4.17.1). [swissprot;acc:p15085]	Divided	53174	44377.4	1.19822
		star-related lipid transfer protein 5 (stard5) (start domain- containing protein 5). [swissprot;acc:q9nsy2]	Subtracted	31100.1	36086.4	4986.3
	Rooted	guanine nucleotide-binding protein-like 1 (gtp-binding protein hsr1). [swissprot;acc:p36915]		49.3451	54.4606	5.1155
		septin 7 (cdc10 protein homolog). [swissprot;acc:q16181]	Divided	113.374	123.463	1.08899
526	Measured	aquaporin-cd (aqp-cd) (water channel protein for renal collecting duct) (adh water channel) (aquaporin 2) (collecting duct water channel protein) (wch-cd). [swissprot;acc:p41181]		10639.9	12117.4	1.13886
		nuclear rna export factor 1 (tip associating protein) (tip-associated protein) (mrna export factor tap). [swissprot;acc:q9ubu9]	Subtracted	5207.78	6010.45	802.67
	Ranked	histone h2b. [refseq;acc:nm_175055]		247.47	233.441	14.029
		nnp-1 protein (novel nuclear protein 1) (nucleolar protein nop52) (nop52) (d21s2056e). [swissprot;acc:p56182]	Divided	250.538	234.401	1.06884
	Squared	electron transfer flavoprotein beta-subunit (beta-etf). [swissprot;acc:p38117]		31189.6	37352.8	1.1976
		keratin associated protein 4.4. [refseq;acc:nm_032524]	Subtracted	31100.2	36086.5	4986.3
	Rooted	atp-dependent rna helicase ddx18 (dead-box protein 18) (myc-regulated dead-box protein) (mrdb). [swissprot;acc:q9nvp1]		49.0882	54.2027	5.1145

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.