MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	Hugo	Value Type	description	Network Comparison Type	Interaction Map	Filtered	red	network_comparison	green

Results: HTML CSV LaTeX

Showing element 2451 to 2500 of 6456 in total

Value Type  : Ranked
Interaction Map  : High confidence
Filtered  : 1

Rank	Hugo	description	Network Comparison Type	red	network_comparison	green
1226	FDX1	adrenodoxin, mitochondrial precursor (adrenal ferredoxin) (hepatoredoxin) (ferredoxin 1). [swissprot;acc:p10109]	Subtracted	191.139	5.257	185.882
	UBE2E4P	ubiquitin-conjugating enzyme e2e 3; ubiquitin carrier protein; ubiquitin-protein ligase. [refseq;acc:nm_006357]	Divided	166.846	1.02483	170.989
1227	GCLM	glutamate--cysteine ligase regulatory subunit (ec 6.3.2.2) (gamma- glutamylcysteine synthetase) (gamma-ecs) (gcs light chain) (glutamate--cysteine ligase modifier subunit). [swissprot;acc:p48507]	Subtracted	213.079	5.246	218.325
	PYCR2	pyrroline 5-carboxylate reductase isoform. [refseq;acc:nm_013328]	Divided	172.365	1.02465	168.219
1228	GCLC	glutamate--cysteine ligase catalytic subunit (ec 6.3.2.2) (gamma- glutamylcysteine synthetase) (gamma-ecs) (gcs heavy chain). [swissprot;acc:p48506]	Subtracted	213.079	5.246	218.325
	GCLM	glutamate--cysteine ligase regulatory subunit (ec 6.3.2.2) (gamma- glutamylcysteine synthetase) (gamma-ecs) (gcs light chain) (glutamate--cysteine ligase modifier subunit). [swissprot;acc:p48507]	Divided		1.02462
1229	no value	integral membrane protein cii-3b. [sptrembl;acc:o75609]	Subtracted	207.646	5.245	212.891
	GCLC	glutamate--cysteine ligase catalytic subunit (ec 6.3.2.2) (gamma- glutamylcysteine synthetase) (gamma-ecs) (gcs heavy chain). [swissprot;acc:p48506]	Divided	213.079	1.02462	218.325
1230	IL4I1	interleukin-4 induced protein 1 precursor (fig-1 protein). [swissprot;acc:q96rq9]		219.55	1.02456	214.288
	SDHC	succinate dehydrogenase cytochrome b560 subunit, mitochondrial precursor (integral membrane protein cii-3) (qps1) (qps-1) (succinate dehydrogenase complex subunit c) (succinate-ubiquinone oxidoreductase cytochrome b large subunit) (cybl). [swissprot;acc:q99643]	Subtracted	207.644	5.244	212.888
1231	PGAM4	putative phosphoglycerate mutase 3 (ec 5.4.2.1) (ec 5.4.2.4) (ec 3.1.3.13). [swissprot;acc:q8n0y7]	Divided	212.724	1.0245	207.637
	SDHB	succinate dehydrogenase [ubiquinone] iron-sulfur protein, mitochondrial precursor (ec 1.3.5.1) (ip) (iron-sulfur subunit of complex ii). [swissprot;acc:p21912]	Subtracted	207.931	5.244	213.175
1232	no value	alpha-1-acid glycoprotein 2 precursor (agp 2) (orosomucoid 2) (omd 2). [swissprot;acc:p19652]		209.649	5.243	204.406
	PYCR1	pyrroline-5-carboxylate reductase (ec 1.5.1.2) (p5cr) (p5c reductase). [swissprot;acc:p32322]	Divided	172.543	1.0245	168.417
1233	no value	phosphoglycerate mutase 1 (ec 5.4.2.1) (ec 5.4.2.4) (ec 3.1.3.13) (phosphoglycerate mutase isozyme b) (pgam-b) (bpg-dependent pgam 1). [swissprot;acc:p18669]		212.724		207.637
	SEPT1	septin 1 (larp) (serologically defined breast cancer antigen ny-br- 24). [swissprot;acc:q8wyj6]	Subtracted	142.077	5.231	136.846
1234	PGAM2	phosphoglycerate mutase 2 (ec 5.4.2.1) (ec 5.4.2.4) (ec 3.1.3.13) (phosphoglycerate mutase isozyme m) (pgam-m) (bpg-dependent pgam 2) (muscle-specific phosphoglycerate mutase). [swissprot;acc:p15259]	Divided	212.724	1.0245	207.637
	UBB	ubiquitin. [swissprot;acc:p02248]	Subtracted	209.6	5.228	204.372
1235	no value	keratin associated protein 9-4; keratin associated protein 9.4. [refseq;acc:nm_033191]	Divided	219.356	1.02447	224.723
	COPA	coatomer alpha subunit (alpha-coat protein) (alpha-cop) (hepcop) (hep-cop) [contains: xenin (xenopsin-related peptide); proxenin]. [swissprot;acc:p53621]	Subtracted	177.432	5.215	182.647
1236	no value	keratin associated protein 4-10; keratin associated protein 4.10. [refseq;acc:nm_033060]	Divided	219.354	1.02437	224.699
	VBP1	prefoldin subunit 3 (von hippel-lindau binding protein 1) (vhl binding protein-1) (vbp-1) (hibbj46). [swissprot;acc:q15765]	Subtracted	226.439	5.179	221.26
1237	no value	keratin associated protein 4-2; keratin associated protein 4.2. [refseq;acc:nm_033062]	Divided	219.354	1.02437	224.699
	PFDN2	prefoldin subunit 2 (hspc231). [swissprot;acc:q9uhv9]	Subtracted	226.439	5.179	221.26
1238	no value	keratin associated protein 4.3 (fragment). [sptrembl;acc:q9byr4]	Divided	219.354	1.02437	224.699
	UXT	uxt protein (ubiquitously expressed transcript protein) (hspc024). [swissprot;acc:q9ubk9]	Subtracted	226.439	5.179	221.26
1239	no value	keratin associated protein 2-4; keratin associated protein 2.4. [refseq;acc:nm_033184]	Divided	219.354	1.02437	224.699
	STAT4	signal transducer and activator of transcription 4. [swissprot;acc:q14765]	Subtracted	222.573	5.178	227.751
1240	no value	keratin associated protein 4-14; keratin associated protein 4.14. [refseq;acc:nm_033059]	Divided	219.354	1.02437	224.7
	STAT1	signal transducer and activator of transcription 1-alpha/beta (transcription factor isgf-3 components p91/p84). [swissprot;acc:p42224]	Subtracted	222.574	5.178	227.752
1241	no value	keratin associated protein 4.9 (fragment). [sptrembl;acc:q9byq8]	Divided	219.354	1.02437	224.7
	STAT3	signal transducer and activator of transcription 3 (acute-phase response factor). [swissprot;acc:p40763]	Subtracted	222.573	5.177	227.75
1242	no value	keratin associated protein 4-12; keratin associated protein 4.12. [refseq;acc:nm_031854]	Divided	219.354	1.02437	224.7
	RALGDS	ral guanine nucleotide dissociation stimulator (ralgef) (ralgds). [swissprot;acc:q12967]	Subtracted	162.055	5.171	156.884
1243	no value	keratin associated protein 1.5. [refseq;acc:nm_031957]	Divided	219.354	1.02437	224.699
	STAT6	signal transducer and activator of transcription 6 (il-4 stat). [swissprot;acc:p42226]	Subtracted	222.569	5.17	227.739
1244	STARD6	star-related lipid transfer protein 6 (stard6) (start domain- containing protein 6). [swissprot;acc:p59095]	Divided	219.354	1.02437	224.7
	TPD52L1	tumor protein d53 (hd53) (d52-like 1). [swissprot;acc:q16890]	Subtracted	206.774	5.162	211.936
1245	KRTAP5-8	keratin, ultra high-sulfur matrix protein b (uhs keratin b) (uhs kerb). [swissprot;acc:o75690]	Divided	219.354	1.02437	224.699
	TPD52	tumor protein d52 (n8 protein). [swissprot;acc:p55327]	Subtracted	206.771	5.155	211.926
1246	no value	keratin, ultra high-sulfur matrix protein a (uhs keratin a) (uhs kera). [swissprot;acc:p26371]	Divided	219.354	1.02437	224.699
	SESN3	sestrin 3. [swissprot;acc:p58005]	Subtracted	218.368	5.149	213.219
1247	SESN2	sestrin 2 (hi95). [swissprot;acc:p58004]
	STARD5	star-related lipid transfer protein 5 (stard5) (start domain- containing protein 5). [swissprot;acc:q9nsy2]	Divided	219.354	1.02437	224.7
1248	CYP4A11	cytochrome p450 4a11 precursor (ec 1.14.15.3) (cypiva11) (fatty acid omega-hydroxylase) (p-450 hk omega) (lauric acid omega-hydroxylase) (cyp4aii) (p450-hl-omega). [swissprot;acc:q02928]	Subtracted	218.368	5.148	213.22
	KRTAP4-4	keratin associated protein 4.4. [refseq;acc:nm_032524]	Divided	219.354	1.02437	224.699
1249	no value	alpha-parvin (calponin-like integrin-linked kinase binding protein) (ch-ilkbp). [swissprot;acc:q9nvd7]				224.7
	CYP4F3	cytochrome p450 4f3 (ec 1.14.13.30) (cypivf3) (leukotriene-b4 omega- hydroxylase) (leukotriene-b4 20-monooxygenase) (cytochrome p450- ltb-omega). [swissprot;acc:q08477]	Subtracted	218.368	5.148	213.22
1250	CYP4F8	cytochrome p450 4f8 (ec 1.14.14.1) (cypivf8). [swissprot;acc:p98187]
	LIMS1	pinch protein (particularly interesting new cys-his protein) (lim and senescent cell antigen-like domains 1). [swissprot;acc:p48059]	Divided	219.354	1.02437	224.7

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.